Báo cáo y học: "Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro" pptx

... Inflammation Open Access Research Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro Jennifer L Strande* 1 and Shane A Phillips 1,2 Address: ... cytokine production in human adi- pose tissue [9,11]. Inflammatory Cytokines and Adipose Tissue Several inflammatory cytokines including TNF-α, IL...

Ngày tải lên: 11/08/2014, 08:22

... anatomically distinct layers: a sur- face layer (intima or synovial lining) and an underlying layer (subintima). The predominant cell types in the nor- mal intima and subintima are macrophage-like (type ... molecules and the release of chemokines upon combined treatment of IL-27 and TNF-α or IL-1β As pro -inflammatory cytokine TNF-α and IL-1β play crucial inflammatory roles...

Ngày tải lên: 12/08/2014, 14:22

... be secreted by macrophages, but not pl atelets, and they play important roles in mediating pro -inflammatory responses. Interestingly, the pro -inflammatory cytokine secretion was also enhanced by platelets ... apoptotic c ells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-bet a, PGE2, and PAF. J C lin Invest 1998, 10...

Ngày tải lên: 11/08/2014, 03:20

... be secreted by macrophages, but not pl atelets, and they play important roles in mediating pro -inflammatory responses. Interestingly, the pro -inflammatory cytokine secretion was also enhanced by platelets ... apoptotic c ells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-bet a, PGE2, and PAF. J C lin Invest 1998, 10...

Ngày tải lên: 11/08/2014, 06:22

... kinds of inflammatory cells, including macrophages, monocytes, T cells, and synovial fibroblasts. TNFα induces other inflammatory cytokines and promotes osteoclastogenesis to destroy the bones. TNFα transgenic ... in the synovial lining cells. We could not detect the IL-32 expression in the synovial lining layers, where monocytes and synovial fibroblasts usually exist. Synov...

Ngày tải lên: 09/08/2014, 08:23

... bone marrow cavity in chronic inflammatory arthritis. Introduction TNF is a clinically validated etiological factor in inflammatory- erosive arthritis and is known to synergize with RANKL and macrophage ... in inflammatory osteolysis. Arthritis Res Ther 2006, 8:201. 2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors: cytokine- stimulated immunomodulators of inflammator...

Ngày tải lên: 09/08/2014, 10:23

... the endo- toxin evolution in blood. Endothelin-1 and inhaled nitric oxide The ET-1 in plasma rose rapidly and markedly already after 1 hour and paralleled the increase in blood endotoxin. There ... pulmonary damage separating responders from nonresponders may be an explanation for the varying responses to INO. Besides, a limitation may include the intra- variability and intervar...

Ngày tải lên: 13/08/2014, 11:23

... using BIAcore analysis. IGF1R binding by all of these analogues has not previously been compared in a single binding assay. Analogues included in this study were originally designed to analyse ... ligand-binding a domains and t wo transmem- brane b domains. The tyrosine kinase domain i s l ocated within the cytoplasmic region and is responsible for s ignal- ling events initiated by li...

Ngày tải lên: 08/03/2014, 22:20

... consequences in T cells. First, rafts may concentrate the a chains (CD25) in the vicinity of signaling IL-2R b and c c chains, forming a common signaling platform in the membrane, before cytokine stimulation. ... Simons, K. (1999) Clusters of glycolipid and glycosylphosphatidyl-inositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine pho...

Ngày tải lên: 17/03/2014, 23:20

... intracellular cytokine staining in patient no. 6HLA-B27/Chlamydia peptide tetramer staining and intracellular cytokine staining in patient no. 6. When synovial T cells where stained with HLA- B27 Chlamydia ... (tetramer staining and intracellular cytokine staining), we investigated whether enrichment of these cells could be achieved by short-term stimulation with autologous...

Ngày tải lên: 09/08/2014, 01:24