Báo cáo y học: "Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of" ppt

... to study the therapeutic effects of systemic infliximab therapy on the synovial expression of other important pro-inflammatory molecules [38,47]. Infliximab treatment in another small cohort of patients ... RA saw the number of TNF-synthesising cells readily reduced and the production of IL-1α and IL-1β incon- sistently down-regulated[47]. IL-15 was not inhibited by an...

Ngày tải lên: 09/08/2014, 10:23

... dendritic cell activation and systemic autoimmunity. Immunity 2003, 19:437-450. 50. Lu Q, Lemke G: Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 2001, ... splenocyte subsets and kidneys of MRL/lpr mice, suggesting that the type II IFN pathway rather than the IFN-I pathway plays the domi- nant pathogenic role in the...

Ngày tải lên: 09/08/2014, 14:22

... Together, transplantation of hMSCscanindeeddelaytheonsetaswellasto improve the motor function of SCA2 transgenic mice. Results of this preclinical study strongly support further exploration of the ... Top University Plan. This work was assisted in part by the Division of Experimental Surgery of the Department of Surgery, Taipei Veterans General Hospital. Author details...

Ngày tải lên: 10/08/2014, 10:20

... circulatory system whereby they secrete inflammatory cytokines and induce the sequelae of inflammation and vascular wall remodeling. Another aspect of VCAM-1 activity has been observed in the presence ... monocytes [18]. These immune-response cells are the scavengers of the circulatory system. When they are activated, they express their own surface adhesion markers, which i...

Ngày tải lên: 11/08/2014, 03:20

... irrespective of the presence of cycloheximide (Figure 8C). Next, we examined the consequences of co -expression of either Vpu or the ROD10 Env on the cellular distribu- tion of the EGFP-tetherin (YY-AA) ... μg of either a Vpu expression plasmid (pcDNA-Vphu) or a ROD10 HIV-2 Env expression plasmid and analyzed by confocal microscopy. Cell surface tetherin was dete...

Ngày tải lên: 13/08/2014, 01:20

... perturbation of miRNA expres- sion levels include a primary effect of HIV-1 on the sta- bility of the miRNA or secondary effect on the expression of the miRNA locus. A r ecent study of the fate of miRNA ... attributable to paracrine signaling or another bystander effect that i s not solely seen by T cell activation. The results sup- port the utility of the c...

Ngày tải lên: 13/08/2014, 01:20

... inflammatory cells to the site of inflammatory lesion, thereby amplify- ing and sustaining the inflammatory condition [8]. The pro-inflammatory cytokines produced by the mast cells and basophils play ... production in the culture supernatant of activated KU812 cells. Effect of POMx on the activation of MAPK Activation of MAPKs is intimately associated with the...

Ngày tải lên: 11/08/2014, 08:22

... influx of leukocytes into the lung tissue. Therefore, we investigate the role of GTE on the neutrophils infiltration by measurement of the activity of myeloperoxidase. Myeloperoxidase activity was ... EMSA), up-regulation of ICAM-1 (by immunohistochemistry); the nitration of tyrosine residues (an indicator of the for- mation of peroxynitrite) (by immunohistoche...

Ngày tải lên: 12/08/2014, 18:21

... them to the broad array of imaging techniques. The study was covered by a quality assurance approval by the Scientific Ethics Committee of Southern Denmark and complied with the Declaration of ... (for examplepeopleorpathologies),despitethemeasure- ment error. Reliability is influenced by the variability in the scores. Therefore, reliability may vary within a study pop...

Ngày tải lên: 13/08/2014, 15:21