Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx

... such as the p38 MAPK path- way [17]. The MAPKs operate as a series of kinase modules beginning with the MAPK kinase kinases (MKKKs), which phosphorylate MAPK kinases (MKKs), which ultimately phosphorylate ... model. These data suggest that p38 inhibitors may be beneficial in the treatment of both joint degeneration and pain associated with OA. Materials...

Ngày tải lên: 11/08/2014, 08:22

... a modification of ACI based on autologous polymer-based three-dimensional chondrocyte grafts. The polymeric matrix used in this study was BioSeed-C (a polyglycolic/polylactic acid and polydioxane based ... On the other hand, when the lesion is completely contained within the avascular articular cartilage layer (partial thickness defects), there is no involvement of the vascula...

Ngày tải lên: 09/08/2014, 10:21

... Reform Right: A Guide To Improving Performance And Equity Oxford: Oxford University Press 2003. 28. Institute of Medicine: Crossing The Quality Chasm: A New Health System For The 21st Century ... Uncertainty and sensitivity analysis techniques as tools for the quality assessment of composite indicators. Journal of the Royal Statistical Society Series A 2005, 168:307-32...

Ngày tải lên: 11/08/2014, 05:21

... palliation, 35 to reduce symp- toms, and 14 as adjuvant therapy. The chemotherapy con- sisted of mitomycin C with or without gemcitabine, and embolization was performed with lipiodol and starch microspheres ... com- pleted planned therapy, the extent of hepatic and systemic toxicity, and, if the data allowed, the response to therapy. All subjects have been evaluated...

Ngày tải lên: 09/08/2014, 04:21

... salpingo-oophorectomy (TAH-BSO) with or without lymph node sampling. The vagina is the most common site of recurrence, and whole pelvic radio- therapy, vaginal cuff brachytherapy, or both types of radi- ation therapy ... disease [2-4]. Vaginal brachytherapy is often employed in the treat- ment of endometrial cancer, either alone or in combina- tion with external beam radiati...

Ngày tải lên: 09/08/2014, 09:20

... atural lesueurin by e lectrospray mass spectrometry, and HPLC. Bioactivity assays Antimicrobial testing. Synthetic lesueurin was t ested for antibiotic activity by the M icrobiology D epartment o f the Institute ... cen tral Lys-Lys pair and the b asic nature of the peptides. It appears that the length of the peptide and this pair of basic r esidues are important in...

Ngày tải lên: 31/03/2014, 15:20

... Disease in the fetus is entirely independent of whether the mother has systemic lupus erythematosus or Sjögren’s syndrome, or is totally asymptomatic [3,4]. One of the most intriguing aspects of ... actin (myofibroblast and blood vessel smooth muscle cells), and then stained with alkaline phosphatase. 268 Arthritis Research & Therapy Vol 5 No 6 Buyon and Clancy healthy...

Ngày tải lên: 09/08/2014, 01:22

... Hoogen FH: The synergistic value of focus score and IgA% score of sublabial salivary gland biopsy for the accuracy of the diagnosis of Sjogren’s syndrome: a 10- year comparison. Rheumatology 2002, ... ELISA and for their comments on the manuscript. We are most grateful to Dr Y Hayashi (Department of Pathology, Tokushima University School of Dentistry, Tokushima,...

Ngày tải lên: 09/08/2014, 01:23

... both of which are useful surrogates for the degree of synovial vascularity [28,29]. Generally, there is a correlation between the severity of synovitis and all of these parameters. Whilst joint ... of the effective treatment of synovitis as being the only necessary and sufficient thera- peutic goal for RA. It is clear that erosive disease is secondary and a...

Ngày tải lên: 09/08/2014, 13:22

... participated in the design of the study, analysis of DXA images, performed the statistical analysis and drafts the man- uscript. JL conceived the study and elaboration of the program used to analyse the ... positive and true negative rate were separately analyzed to identify the percentage of OA cases and non-cases cor- rectly predicted by the models. In addi...

Ngày tải lên: 09/08/2014, 14:22