Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx
Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx
... such as the p38 MAPK path-way [17]. The MAPKs operate as a series of kinase modulesbeginning with the MAPK kinase kinases (MKKKs), whichphosphorylate MAPK kinases (MKKs), which ultimatelyphosphorylate ... model. These data suggest that p38 inhibitors maybe beneficial in the treatment of both joint degeneration and pain associated with OA.Materials and methodsP38 kinase inhibitors The p38 kinase inhibitors ... reso-nance, mass spectroscopy and elemental analysis. The purity of the compounds was > 99% as determined byhigh performance liquid chromatography. Kinase assay procedureP38 kinase (Upstate...
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Báo cáo y học: "A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects" ppsx
... amodification of ACI based on autologous polymer-basedthree-dimensional chondrocyte grafts. The polymeric matrixused in this study was BioSeed-C (a polyglycolic/polylacticacid and polydioxane based ... On the other hand, when the lesion is completely contained within the avascular articular cartilage layer (partial thicknessdefects), there is no involvement of the vasculature, and blood and ... on the fabrication protocol of the tissue-engineered cartilage graft. For example, the exact cell densityper volume of the construct was not given, and neither weredetails of the pre-surgery...
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Báo cáo y học: "Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" docx
... Reform Right: AGuide To Improving Performance And Equity Oxford: Oxford University Press2003.28. Institute of Medicine: Crossing The Quality Chasm: A New Health System For The 21st Century ... Uncertainty and sensitivity analysistechniques as tools for the quality assessment of composite indicators.Journal of the Royal Statistical Society Series A 2005, 168:307-323.43. Parry GJ, Gould ... research. These include paucity of interactions with the healthc are system, paucity of criti-cal health outcomes, and availability of quality of life and prevention metrics. We will focus on aspects...
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Báo cáo khoa học: "Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report" pdf
... palliation, 35 to reduce symp-toms, and 14 as adjuvant therapy. The chemotherapy con-sisted of mitomycin C with or without gemcitabine, and embolization was performed with lipiodol and starchmicrospheres ... com-pleted planned therapy, the extent of hepatic and systemictoxicity, and, if the data allowed, the response to therapy.All subjects have been evaluated for safety. Exposure to the study drug is summarized ... site. Acentral assessment of tumor response was performed for all patients by the Principal Investigator at University of Louisville. When there was a discrepancy, the Registry PI and the site PI...
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Báo cáo khoa học: "Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial cancer" ppsx
... salpingo-oophorectomy (TAH-BSO) with or without lymph node sampling. The vagina is the most common site of recurrence, and whole pelvic radio-therapy, vaginal cuff brachytherapy, or both types of radi-ation therapy ... disease [2-4].Vaginal brachytherapy is often employed in the treat-ment of endometrial cancer, either alone or in combina-tion with external beam radiation. Vaginal brachytherapyhas typically ... radi-ation therapy may follow surgical treatment. Radiationtherapy significantly decreases the risk of local regionalrecurrence and has been associated with improved sur-vival in patients with stage...
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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... aturallesueurin by e lectrospray mass spectrometry, and HPLC.Bioactivity assaysAntimicrobial testing. Synthetic lesueurin was t ested for antibiotic activity by the M icrobiology D epartment o f the Institute ... cen tral Lys-Lys pair and the b asic nature of the peptides. It appears that the length of the peptide and this pair of basic r esidues are important in determ ining the magnitude of the nNOS ... [22], at least partly because they s howstructural similarity to the human brain endomorphins (e.g.YPWG-NH2) [23]. The sequences of two tryptophyllins are as follows: tryptophyllin L1, FPWL-NH2;...
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Báo cáo y học: " From antibody insult to fibrosis in neonatal lupus – the heart of the matter" pps
... Disease in the fetus is entirely independent of whether the mother has systemic lupus erythematosus orSjögren’s syndrome, or is totally asymptomatic [3,4].One of the most intriguing aspects of ... actin (myofibroblast and blood vessel smoothmuscle cells), and then stained with alkaline phosphatase.268Arthritis Research & Therapy Vol 5 No 6 Buyon and Clancyhealthy control. Other investigators ... the pathogenesis of antibody -associated CHB and the rarity of irreversible injury, and may provide a ratio-nale for therapy.Competing interestsNone declared.Acknowledgements The original work...
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Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome" pot
... Hoogen FH: The synergistic value of focusscore and IgA% score of sublabial salivary gland biopsy for the accuracy of the diagnosis of Sjogren’s syndrome: a 10-year comparison. Rheumatology 2002, ... ELISA and for their comments on the manuscript. We are most grateful to Dr Y Hayashi (Department of Pathology, Tokushima University School of Dentistry, Tokushima, Japan) for providing us with the ... unknown origin. Therefore the diagnosis of SjS, in the absence of a gold standard, is based on cri-teria containing a number of subjective and objectivesigns and symptoms. In the past three decades,...
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Báo cáo y học: "What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years" doc
... both of which are useful surrogates for the degree of synovialvascularity [28,29]. Generally, there is a correlation between the severity of synovitis and all of these parameters.Whilst joint ... of the effective treatment of synovitis as being the only necessary and sufficient thera-peutic goal for RA. It is clear that erosive disease issecondary and a predictable consequence of synovitis, ... PMR- associated hand disease has a similar degree of MRI boneerosion and bone oedema compared with early RA [31].Furthermore, in the proof -of- concept study in question, the PMR group eventually...
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Báo cáo y học: "Dual energy x-ray absorptiometry analysis contributes to the prediction of hip osteoarthritis progression" pdf
... participated in the design of the study, analysis of DXAimages, performed the statistical analysis and drafts the man-uscript. JL conceived the study and elaboration of the programused to analyse the ... positive and true negative rate were separately analyzedto identify the percentage of OA cases and non-cases cor-rectly predicted by the models. In addition, Nagelkerke R2 wasused to measure the ... degenerated joints at baselineprogress differently than a joint in the early phase of the dis-ease. In terms of our definition of progression it is clear thatadvanced OA joints with an already small...
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