... [47] to count the number of nonsynonymous and synonymous sites and to determine the number of nonsynonymous and synonymous changes between two codons. Male flies are hemizygous for the X chromosome. ... cut-offs are arbitrary and chosen because they resulted in about half of the genes falling into 'average' gene expres- sion and the remainder of the genes falling roughly e...
Ngày tải lên: 14/08/2014, 20:22
... of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Science and Technology, Okayama University, Japan; 2 Department of Biology, Faculty of Sciences, University ... rowth-inhibitory eect was also attenuated by this modi®cation. These results suggest that growth inhibition by ECP is dependent on cell type and is cytostatic. Keywords: cell cycle; colo...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... route. Inhibition of the p38 MAPK route may inhibit production not only of TNF-α, but also of other inflammatory mediators produced by macrophages, and indirectly of inflammatory mediators by other ... lining layer consists mainly of fibroblasts and macrophages, both important players in the process of inflammation by the production of cytokines and degrading enzymes. Rece...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... pharmacological effects of dnIκB transgene expression in HUVECs by analysis of mRNA levels of typical cell adhesion molecules, cytokines and some other angiogenesis-related genes in HUVECs upon TNF-α ... microscop- ically as well as by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) viability assay (data not shown). To further confirm the inhibitory effects of the...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Antioxidant activity of tuberosin isolated from Pueraria tuberose Linn" pot
... l], (3’ - hydroxy-4’-phenoxy-a,b-epoxychalcan-a’ol)] [9], Ptero- carpanoids [Hydroxytuberosin, Anhydroxytuberosin (3-O-meth ylanhydrotuberosin)] [10], and Tuberosin [11]. The powder of PT root-tubers ... add-on therapy with conventio nal medicine. The powder of PT r oot-tubers are already in clinical use by Ayurvedic physicians of Indian system of medi- cine [6], but neither its mecha...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot
... variety of in vitro and cell culture studies [8,9]. Additionally to its radical scavenging activity an inhibition of NF-κB-dependent gene expression and decrease of the activity of various pro -inflammatory ... maritime pine bark extract (Pycnogenol ® ) displays a variety of anti -inflammatory effects in vivo. Aim of this study was to determine whether human plasma after ora...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot
... as products of sPLA2 hydrolysis. For example, the contribu- tion of lysoPCs to atherosclerotic lesions is a prime exam- ple of ability of sPLA2 enzyme activity to direct a local injurious inflammatory ... toxicity of excess lysoPCs cannot be ignored, so there is likely an upper limit of lysoPC dos- ages that will accomplish the inhibition without cytotox- icity. Dose limitatio...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
... Zeng Z, Li H, Li Y, Cui Y, Zhou Q, Zou Y, Yang G, Zhou T: Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences. Acta Biochim Biophys Sin 2009, 41:389-398. 21. ... participated in gene cloning, sequence alignment, transfection, data anal- ysis and drafting of the manuscript. YQL initially conceived of the study. ZFZ helped with PCR...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: " Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system" pdf
... scave ngers of oxidant radicals, especially hydroxyl radical [33,34]. The well- described antioxidant activity of vitamin E (tocopherol) is primarily due to the capacity of its heterocyclic chroma- nol ... only nasal symptom measure to show significant change during the study. Inhibition of endotoxin-induced pro -inflammatory gene expression by the oil preparation In order to pur...
Ngày tải lên: 12/08/2014, 13:22
Báo cáo y học: " Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury" doc
... using different gene knock-out settings. We investigated the efficacy of pharmacological inhibition of leukotrienes activity in the development of bleomycin-induced lung injury by comparing the ... computer, the assay was performed. Myeloperoxidase activity assay Myeloperoxidase (MPO) activity, an indicator of poly- morphonuclear leukocyte (PMN) accumulation, was determined as pre...
Ngày tải lên: 12/08/2014, 16:20