Báo cáo y học: "Product inhibition of secreted phospholipase

Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot

... purposes) Journal of Inflammation Open Access Research Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties Timothy J Cunningham*, ... as products of sPLA2 hydrolysis. For example, the contribu- tion of lysoPCs to atherosclerotic lesions is a prime example of ability of sPLA2 enzyme activity...

Ngày tải lên : 11/08/2014, 08:22

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Báo cáo y học: "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice" ppt

... of LY315920/S- [3-(aminooxoacetyl)-2-ethyl-1-(phenylmethyl)- 1H-indol-4-yl] oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol ... amplification loop for propagation of inflammatory responses [7]. Hence, inhibition of sPLA 2 may logically block the formation of a wide variety of secondary infl...

Ngày tải lên : 09/08/2014, 14:22

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Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx

... of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Science and Technology, Okayama University, Japan; 2 Department of Biology, Faculty of Sciences, University ... effect of growth inhibition may be replicated by other polycations. To investigate this, we checked the effect of poly( L -lysine), which has a cationic charge that is almost equiva...

Ngày tải lên : 17/03/2014, 17:20

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Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt

... route. Inhibition of the p38 MAPK route may inhibit production not only of TNF-α, but also of other inflammatory mediators produced by macrophages, and indirectly of inflammatory mediators by other ... lining layer consists mainly of fibroblasts and macrophages, both important players in the process of inflammation by the production of cytokines and degrading enzymes. Recent...

Ngày tải lên : 09/08/2014, 01:23

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Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx

... previously [15]. In brief, an aliquot of heterobifunctional polyethylene gly- col (PEG) linker (3.4 kDa) with a N-hydroxysuccinimide ester and vinyl sulfone group at each end of the molecule (NEKTAR Therapeutics, ... microscop- ically as well as by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) viability assay (data not shown). To further confirm the inhibitory effect...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot

... recently elucidated the cellular effects of δ- (3,4-dihydroxy-phenyl)-γ-valerolactone and δ-(3-meth- oxy-4-hydroxy-phenyl)-γ-valerolactone and uncovered an antioxidant activity as well as the potential ... δ-(3-meth- oxy-4-hydroxy-phenyl)-γ-valerolactone [10]. Valerolac- tone derivatives were also found after ingestion of green tea [11]. These newly formed metabolites may display sig- n...

Ngày tải lên : 11/08/2014, 08:21

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Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx

... Zeng Z, Li H, Li Y, Cui Y, Zhou Q, Zou Y, Yang G, Zhou T: Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences. Acta Biochim Biophys Sin 2009, 41:389-398. 21. ... sequence alignment, transfection, data anal- ysis and drafting of the manuscript. YQL initially conceived of the study. ZFZ helped with PCR amplification on many of the se...

Ngày tải lên : 12/08/2014, 04:20

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Báo cáo y học: " Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury" doc

... investigated the efficacy of pharmacological inhibition of leukotrienes activity in the development of bleomycin-induced lung injury by comparing the responses in wild-type mice with mice treated ... computer, the assay was performed. Myeloperoxidase activity assay Myeloperoxidase (MPO) activity, an indicator of poly- morphonuclear leukocyte (PMN) accumulation, was determined as pre...

Ngày tải lên : 12/08/2014, 16:20

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Báo cáo y học: "Retraction: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx

Ngày tải lên : 13/08/2014, 01:20

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Báo cáo y học: " Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome" pps

... mutant R1 may lack target sequences for trans -inhibition by AS19. Mechanism of trans -inhibition by HIV-lhNef and the AS variants We have previously described strong inhibition of HIV-1 by RNAi-inducing ... http://www.retrovirology.com/content/4/1/15 Page 11 of 14 (page number not for citation purposes) Test of sequence-specificity of the inhibition by HIV-lhNefFigure 7 Te...

Ngày tải lên : 13/08/2014, 09:20

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Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''''''' unexpected therapeutic properties" pot

Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot

Báo cáo y học: "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice" ppt