... Immunology, University of Rostock, Rostock, Germany2Institute of Pathology, University of Rostock, Rostock, Germany3Institute of Neurology, University of Rostock, Rostock, Germany4Section for ... disease, namely tissue destruction andsynovial hyperplasia. In this study we examined the role ofperforin (pfp), a key molecule of the cytotoxic death pathway thatis expressed mainly in CD8+ ... collagen type II; CTL = cytotoxic T lymphocyte; EAE = experimental autoimmune encephalomyelitis; ELISA = enzyme-linked immunosorbent assay; FITC = fluorescein isothiocyanate; H & E = hematoxylin...