Báo cáo y học: "IFN-gamma regulation of ICAM-1 receptors in bronchial epithelial cells: soluble ICAM–1 release inhibits human rhinovirus infectio" pptx

... purposes) Journal of Inflammation Open Access Research IFN-gamma regulation of ICAM-1 receptors in bronchial epithelial cells: soluble ICAM–1 release inhibits human rhinovirus infection Suzanne ... binding/internalisa- tion. A down -regulation in mICAM-1 expression on the epithelial cell surface may limit rhinovirus infection by decreasing the number of...

Ngày tải lên: 11/08/2014, 08:22

... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is characterised by ... airway hyperreactivity in animal studies [12-14], they may have distinct roles in allergen-dependent airway obstruction [24]. Hence, NGF may play a role in the early airway response (EAR) in...

Ngày tải lên: 12/08/2014, 16:20

... other indications of immune activation emerged in the set of over-expressed genes, including pro- inflammatory cytokines, chemokines, granzymes, protein- ases, and receptors for inflammatory mediators ... microarray analysis identified 209 genes that were differentially expressed in circulating leukocytes from 14 high- versus low-lonely individuals, including up -regulation of ge...

Ngày tải lên: 14/08/2014, 08:20

... with an incidence of 0.2 – 1.5% worldwide [1]. A larger body of literature has been presented in the last decades providing further insight into tumor biology and clinical behaviour of thymomas ... analysis because of incomplete follow-up; overall 82 patients were introduced to survival analysis. Clinical Pathology and Immunhistochemical Staging Hematoxylin-eosin-stained sections o...

Ngày tải lên: 10/08/2014, 10:20

... infiltrate of macrop hages and lymphocytes, but no evidence of malignancy was found. The patient contin ued to e xperience abdominal pain and ursodeoxycholic acid was introduced to treat any potential ... pancreatitis occurring in an older adult with pancreatic insufficiency and cystic fibrosis but in the setting of normal amylase and l ipase. The few reports available concerning ac...

Ngày tải lên: 11/08/2014, 03:21

... the action of sodium metabisulphite on mucociliary transport in a frog palate epithelial injury model, hypothesizing that it may be useful for the study of mechanisms of airway injury. Sodium ... frog Ringers was applied to the palate in twenty-minute inter- vals followed by a measurement of MCT. The average frog Ringers MCT (in 7 frogs) measured initially at 15 minutes followi...

Ngày tải lên: 12/08/2014, 18:21

... unknown precisely. In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen- activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene and protein ... diacylglycerol (DAG) binding site of the enzyme to block its activity [41]. Our findings suggested that NO activated both α and δ forms of PKC which in turn involved in MUC5A...

Ngày tải lên: 12/08/2014, 15:20

... hypersecretory phenotype in chronic air- way inflammatory states. Consequently, those studies explored the effects of cytokines and proteolytic enzymes upon a variety of secretory mucin genes including MUC2, MUC5AC, ... following epithelial damage in airways of asthmatics. In this study, we investigated the potential role of IL-4, one of the Th2 inflammatory cytokines persis...

Ngày tải lên: 12/08/2014, 16:20

... lipoxygenase by binding to the reduced form (Fe 2+ )oftheenzyme thereby keeping it inactive [49]. In our experiments NDGA was effective in inhibiting the activity of purified recombin- ant MTE-I in an in ... 5-min preincubation of recombinant protein with NDGA inhibited thioesterase activity. Interestingly, NDGA produced only a 20% inhibition of the mitochondrial enzyme activity...

Ngày tải lên: 08/03/2014, 09:20

... access [14]. In contrast to all Fe-hydrogenases including HydA of S. obliquus,the enzyme of C. reinhardtii has an interesting additional protein domain. A small insertion of 45 amino acids between ... synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA of C. reinhardtii, the first isolated gen...

Ngày tải lên: 08/03/2014, 22:20