Báo cáo y học: "Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients" pdf

... patients were determined using a Quantikine ELISA kit (R&D Sys- tems). Statistical analysis Statistical analysis was carried out using the StatView sta- tistical analysis software (SAS, Cary, NC, USA). ... of phosphotyrosine-containing proteins, platelet-derived growth factor- B, and fibroblast growth factor- 1 in situ in syn- ovial tissues of patients with rheumatoid art...

Ngày tải lên: 11/08/2014, 08:21

... a proinflammatory role in acute hyperoxic lung injury. Background Supplemental oxygen therapy is administered for the treatment of tissue hypoxia, most commonly in an inten- sive care setting of respiratory ... development of acute hyperoxic lung injury within a few days. Upon hyperoxic exposure, the inducible nitric oxide synthase (iNOS) is activated by a variety of proin...

Ngày tải lên: 12/08/2014, 18:21

... they have no competing interests. Authors' contributions SA, AL, and GF conceived of the study and participated in its design and coordination, in data acquisition and analysis, and in manuscript ... agents in rheumatoid arthritis: a systematic review of the literature Stefano Alivernini, Antonella Laria, Elisa Gremese, Angelo Zoli and Gianfranco Ferraccioli Division of...

Ngày tải lên: 09/08/2014, 14:22

... Schaible HG: Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain. Arthritis Rheum 2007, 56:351-359. 14. ... Barbieri M: Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)- glycinamide hydrochloride (CHF3381) in experimental models of infl...

Ngày tải lên: 12/08/2014, 14:22

... phenotypical analysis of dis- tinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Res Ther 2006, 8:R15. 12. De Rycke L, Baeten D, Kruithof E, Bosch F Van den, Veys ... AH: Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J In...

Ngày tải lên: 09/08/2014, 14:22

... binding loop of cystatin A fulfils the same function as the second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To ... cathepsin B, demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may be directly involved in the interact...

Ngày tải lên: 17/03/2014, 10:20

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To ... doi:10.1046/j.1432-1033.2002.02857.x An interesting property of bF24A is its increased esterase/ amidase ratio. In general the enzyme-catalysed hydrolysis of esters is faster than...

Ngày tải lên: 17/03/2014, 23:20

... distinct changes in the zinc ligands. In the His237 fi Ala and Cys239 fi Ala mutants, coenzyme M also seemed to bind efficiently by ligation to zinc indicating that some aspects of the zinc ligand ... S-methyl- methionine:homocysteine methyltransferase [17], epoxy- alkane:coenzyme M transferase [18] and protein farnesyl transferase [19]. The postulated role of zinc in these enzymes i...

Ngày tải lên: 17/03/2014, 23:20

... proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/or carboxylate of the bicyclic b-lactam nucleus, with the pro-S methyl group ... been significantly advanced by the determination of the crystal structure of wild-type and mutant DAOCS with various ligands [1,11–13]. However, a detailed understanding of...

Ngày tải lên: 18/03/2014, 01:20

... delivery. The frequency of developing atopic dermatitis in the offspring was significantly reduced by 2, 4, and 7 years [26-28], by 50%, 44%, and 36% respectively. Similar studies have yielded ... purposes) c) The role of probiotics in Allergic Rhinitis Reports on the efficacy of probiotics in treating allergic rhinitis are conflicting. Some studies suggest efficacy such as the...

Ngày tải lên: 08/08/2014, 21:20