Báo cáo y học: "Green tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats" pdf

... Corresponding authors Abstract Background: Tristetraprolin (TTP/ZFP36) family proteins have anti-inflammatory activity by binding to and destabilizing pro-inflammatory mRNAs such as Tnf mRNA, and ... Recently, it was demonstrated that tea catechins directly bind to DNA and preferentially bind to poly(A), poly(U), and poly(AU) in RNA [42]. It will be interesting to investig...

Ngày tải lên: 11/08/2014, 08:21

... recombinant HMGB1 (rHMGB1) induces arthritis in animals and shares key histological features observed in RA, including pannus formation, synovial membrane hypertrophy, and mononuclear cell predominance ... within synovial tissue [7]. The injection of rHMGB1 results in mild to moderate synovitis and may persist for at least 28 days. The induction of arthritis by rHMGB1 is primarily...

Ngày tải lên: 09/08/2014, 10:23

... are maintained in the clinical setting. In contrast, in experimental studies, when no other support measures are applied, oxygen- ation may play a crucial role in survival. In the same way, ani- mals ... model. J Clin Invest 1997, 99:944-952. 20. Sznajder JI, Ridge KM, Saumon G, Dreyfuss D: Lung injury induced by mechanical ventilation. In Pulm Edema Edited by: Matthay M, Ingbar D...

Ngày tải lên: 13/08/2014, 08:21

... p38-MAPK and JNK activation. In addition, EGCG inhibited the phosphorylating activity of IKKβ kinase in an in vitro activity assay and EGCG inhibited the AGE- mediated activation and DNA binding activity ... kinase (IKK) activity was determined using an in vitro kinase activity assay. MMP-13 activity in the culture medium was assayed by gelatin zymography. Results EGCG signifi...

Ngày tải lên: 09/08/2014, 14:20

... a successful in vitro and in vivo testing of delivering EGCG in polylactic acid–polyethylene glycol nano- particles to inhibit angiogenesis and induce apoptosis [79]. Similarly, the results ... [41]. In a recent study, Yun and colleagues showed that EGCG treatment resulted in dose-dependent inhibition of TNFα-induced production of MMP-1 and MMP-3 at the protein and...

Ngày tải lên: 12/08/2014, 12:20

... skin cancers. Topical treatment of the mouse skin with EGCG or oral administration of GTPs in drinking water of mice signifi cantly inhibited UVB radiation-induced in amma- tory responses, and ... genicity of  17, a major eff ector cell driving in amma tion and auto- immunity [8]. In the photocarcino genesis model, UV radiation-induced in ammation has been implicated in nonm...

Ngày tải lên: 12/08/2014, 17:22

... predominantly by activated macrophages and lymphocytes mediate many inflamma- tory processes [49]. These proinflammatory cytokines include interferon-γ (IFN-γ), interleukin-1 (IL-1), tumour necrosis ... anti-inflammatory effects. Lung inflammation is characterised by T-cell rich infiltrates and enhanced expression of pro-inflammatory cytokines. The signalling pathway of IFN-γ, secre...

Ngày tải lên: 12/08/2014, 18:21

... in vivo studies demonstrated that polyphenols from green tea were anti-carcinogenic by inducing apoptosis and inhibiting cell-growth, cyclin- dependent kinase inhibitor and urokinase (an enzyme crucial ... polyphenols in green tea were conducted [7,8]. The evidence suggests that ingested polyphenols and their metabolites play a role in the action against gastrointestinal cance...

Ngày tải lên: 13/08/2014, 15:21

... to study the ability of β-cyclodextrin (β-CD) or hydroxypropyl β-cyclodextrin (HP-β-CD) to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug, indomethacin or ... produced by restraint and cold stress, even with the added stress from administration of either indomethacin or piroxicam. Key words: β-cyclodextrin, hydroxypropyl β-cyclodextrin, indomethacin...

Ngày tải lên: 26/10/2012, 08:57

... strains and growth P. mirabilis strains G1 and D52 were kindly provided by J. Gmeiner (Institute for Microbiology and Genetics, Darmstadt, Germany). Strain G1 was a clinical isolate from urine ... Zablotni 1 , Alexander S. Shashkov 2 and Yuriy A. Knirel 2 1 Department of General Microbiology, Institute of Microbiology and Immunology, University of Lodz, Poland; 2 N.D. Zelinsky Insti...

Ngày tải lên: 21/02/2014, 15:20