Báo cáo y học: "Early Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts" potx

... the role of Nurr1 in regulating inflammatory processes in syn- ovial cells, and by using transcript profiling to identify Nurr1 regulated genes in synoviocytes, which may be playing a role in the ... an increased expression of Nurr1 in the synovium of patients with rheumatoid arthritis (RA) suggesting a pro-inflammatory role for Nurr1 in RA. In this study we inve...

Ngày tải lên: 11/08/2014, 08:21

... examination, routine blood screening tests, urinalysis, chest X-ray, ECG and pulmonary function testing. Current smoking status was confirmed by his- tory, venous carboxyhemoglobin levels and urinalysis ... carbon skeleton into the tricarboxylic acid cycle, is the final enzyme of GABA catabolism [1]. GABAergic system genes are present not only in the brain, but also in other organs, inc...

Ngày tải lên: 12/08/2014, 11:22

... generally well conserved in all analysed HIV-1 proviral DNA [3]. Analy- sis of the hydrophobic profile of the potentially encoded protein revealed it to be highly hydrophobic and thus to possibly be ... activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene 2005, 24:1001-1010. 16. Briquet S, Vaquero C: Immunolocalization studies of an anti- s...

Ngày tải lên: 13/08/2014, 05:22

... of complement in the system and lack of CRs/FcRs on tar- get or bystander cells. In recent years, a number of anti- body effector functions have been observed in ear ly HIV infection, including ... Left panel: the involvement of CR2 in C’-ADE was initially investigated by pre-incubating SupT1/R5 cells with increasing concentrations of C3dg ligand-blocking mAb 1048, and non-b...

Ngày tải lên: 13/08/2014, 01:20

... Knee instability is very likely to increase inappropriate mechanical loading in many parts of the joint and, in keeping with this, col II and YKL40 expression rose in all locations after ACLT in ... These findings indicate that elevated collagen type II, collagen type I and YKL40 mRNA expression levels are early and sensitive measures of ACLT-induced joint instability independent...

Ngày tải lên: 09/08/2014, 06:22

... expres- sion in joints affected by AIA on Day 1. Abundant stain- ing was detected in the synovial lining layer, joint exudate and focal areas of synovial infiltration; it was comparable in WT and ... mice respectively; intense positive brown staining (denoted by black block arrows) present in the synovial lining layer, joint exudate and focal areas of inflamed synovium, (o...

Ngày tải lên: 12/08/2014, 12:20

... by other DNA-binding proteins such as FoxA2. I mportantly, our research may clarify additional f unctions of TTF-1 and FoxA2 that already are known to interact in the Figure 5 Immunostaining of ... development by significantly reducing branching morpho- genesis [35], increasing rates of respiratory illness [36], irreversibly altering pulmonary function [37], and perma- nently obstruct...

Ngày tải lên: 12/08/2014, 13:22

... Commentary Shock is a syndrome, which is characterized by inadequate tissue perfusion. Shock can have a variety of underlying causes, including hypovolemia, sepsis, cardiac pump dysfunction, ... program, including changes in case-mix, could have biased the study in favor of the intervention. Importantly, the unadjusted p-value (p=0.035) for the study’s primary outcome, hospita...

Ngày tải lên: 12/08/2014, 23:23

... response to injury, and the contribution of non-renal factors may all in uence the timing of initiation. Timing of dialysis initiation is a potentially modifi able factor that may play an important ... Durmaz I, Yagdi T, Calkavur T, Mahmudov R, Apaydin AZ, Posacioglu H, Atay Y, Engin C: Prophylactic dialysis in patients with renal dysfunction undergoing on-pump coronary artery by...

Ngày tải lên: 13/08/2014, 20:21

... capability of promptly intubating failing patients. Thus our findings may not be reproducible in units less experienced in NPPV. Finally, a criticism may be also directed to the choice of CMV-treated ... application of NPPV. The choice of including episodes of CAP in place of simple exacerbations of COPD was based on the intention of 'stressing' the model of...

Ngày tải lên: 13/08/2014, 20:22