Báo cáo y học: " Regulation of IκBα expression involves both

Báo cáo y học: " Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways." ppt

... induction of IκBα in the IκBα- luc transgenic mice by LPS. We demonstrated involvement of both the NF-κB and the p38 MAP kinase signaling pathways in the induction of IκBα expression by LPS. Clinically, ... expression in the early stage of the LPS response is consistent with a tight auto -regulation of the NF-κB signaling pathway by IκBα...

Ngày tải lên : 11/08/2014, 08:21

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Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc

... upstream of the luciferase gene, a nd the resulting plasmid constructs were transiently transfected into cultured cells. In view of the relatively low efﬁciency of transfection of primary endothelial ... responsible for the hyperacute vascular rejection occurring in pig-to-primates organ trans- plantation. The synthesis of the aGal epitope is catalyzed by the enzyme a1...

Ngày tải lên : 08/03/2014, 16:20

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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt

... predominantly of the proteoglycan aggrecan and type II collagen and is highly hydrated, whereas the AF is made up of concentric lamellae of highly organised type I collagen fibres that provide the tensile ... gene expression in normal and degenerate NP cells as well as the effect of IL-1β and TNF-α on cytokine gene expression and the expression of the ass...

Ngày tải lên : 09/08/2014, 14:20

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Báo cáo y học: "Regulation of chondrocyte gene expression by osteogenic protein-1" ppt

... the analysis of the expression data we used a three step analytical strategy: (I) processing of raw inten- sity values and normalization of profiles, (II) examina- tion of expression levels of ... regulation of cytokines and various catabolic pathways responsible for matrix degradation and cell death. Importantly, in many of these cases, OP-1 modulated the ex...

Ngày tải lên : 12/08/2014, 15:22

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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx

... ODC to produce putrescine, the precursor of spermidine and spermine. To further ana- lyze the regulation of the polyamine-synthetic pathway in virus infection, ODC expression in SeV-infected Jurkat ... TNF-a-induced apoptosis [38]. As both NF-jB and JNK pathways are activated by virus infection, these pathways may be targets of the pro-apoptotic activity of sperm...

Ngày tải lên : 07/03/2014, 21:20

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Báo cáo y học: " Hydrodebridement of wounds: effectiveness in reducing wound bacterial contamination and potential for air bacterial contaminatio" pptx

... on the left side of the room (Front and Back) at 1 m, 2 m and 3 meters from the trolleyFigure 6 Shows the settle plates whilst debriding using Versa- jet on the left side of the room (Front and ... the potential for aerosolization of microbes during hydrodebridement therapy and additionally determine the effectiveness of hydro surgery in reducing the amou...

Ngày tải lên : 10/08/2014, 21:23

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Báo cáo y học: " Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells" doc

... Tat-associated kinase, is a mem- ber of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. ... White and members of the Baylor College of Medicine Microarray Core Laboratory for microarray experiments. We thank Yan Wang for providing the reporter virus and Wend...

Ngày tải lên : 13/08/2014, 09:20

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Báo cáo y học: "κ Regulation of NFκB signalling during inflammation: the role of hydroxylases" potx

... under- standing of the mechanism of hypoxia-induced NFκB activity. The fact that the inhibitory action of hydroxylases is at the level of the IKK complex through suppression of catalytic activity means ... inflammation, makes the use of PHDIs an attractive potential therapeutic strategy in IBD. Conclusions Identification of the co -regulation of NFκB and HIF...

Ngày tải lên : 09/08/2014, 01:22

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Báo cáo y học: " Regulation of Sox9 activity by crosstalk with nuclear factor-κB and retinoic acid receptors" pptx

... effect of TNF-α on Sox9 activity. Finally, the sensitivity of Sox9 to atRA was reduced by caMEKK1 expression. Thus, the activity state of p300, the common co-factor and MEKK1 target, probably plays ... p300 Differences in the affinity for p300 may contribute to the pat- tern of regulation of transcription factor activity observed in the present study. Because atRA r...

Ngày tải lên : 09/08/2014, 10:22

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Báo cáo y học: " Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells" ppsx

... as systemic lupus erythematosus (SLE) and psoriasis by their dysregulated production of type I IFNs through engagement of endosomal TLR9 by self-DNA with autoantibody [12-15]. Secretion of type ... inhibitory activities in regards to both IFN- α and TNF-α in pDCs is that BAY11 targets IKKα in the inhibition of IFN-α and IKKβ in the inhibition of TNF-α at the downstream...

Ngày tải lên : 12/08/2014, 12:20

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Báo cáo y học: " Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways " ppt

Báo cáo y học: " Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways." ppt

Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc