Báo cáo y học: " CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection" pps

... lung edema; microvascular permeability; mRNA; ELISA analysis; and histopathological and immunohisto- chemical analysis by fixing in 4% paraformaldehyde at 25 to 30 cm H2O pressure and embedding ... Access Research CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection Vedang A Londhe 1 , John A Belperio 2 , Michael P Keane 2 , Marie D Burd...

Ngày tải lên: 11/08/2014, 08:21

... assistance or regimen change, to minimise disease progression. If established, this approach will clearly allow for the level of adherence to drug therapy regimes to be monitored. Additionally, ... assessed. Implications of the hypothesis Whilst clearly preliminary work to validate this hypothe- sis needs to be undertaken, if validated the information gained could be used to cor...

Ngày tải lên: 10/08/2014, 05:21

... Animals published by the US National Institutes of Health (NIH Publication No. 85-23, revised 1996) Histopathologic Analysis For histological analysis the animals underwent autopsy on days 21 (n = 5 ... (Figure 1E). Discussion In this study, we have demonstrated for the first time that PLGA NPs is an excellent system for intracellular delivery of rapamycin in excised veins. This NPs s...

Ngày tải lên: 10/08/2014, 09:21

... inhibitors. To further explore these issues, it is of significance to perform gene chip (microar- ray) analysis and identify genes regulated by sitagliptin (or other DPP-4 inhibitors), followed by ... (body weight/body h eight = 64 kg/167 cm). His HbA1c level was above 7.5% in the three months prior to this study. Sita gliptin (50 mg/day) was added to the patient’s therapeutic regim...

Ngày tải lên: 11/08/2014, 00:23

... have not been satisfactory for advanced disease which creates bony destruction [4]. Total joint replacement arthroplasty is the standard treatment for severe arthritis and deformity of the knee [5], ... Discussion RA is a systemic disease primarily affecting the synovium. When pharmacologic agents fail to control the inflamma- tory process of the synovium, symptomatic joint destruc-...

Ngày tải lên: 11/08/2014, 17:21

... girls should receive family planning information before age 15, while only 16% felt this to be appropriate for boys. Women responded signif- icantly more positively to attitude questions than ... revision of the paper. MB designed the study, contributed to acquisition, analysis and inter- pretation of data, and critical revision of the paper. All authors approved the version to be...

Ngày tải lên: 13/08/2014, 13:21

... coagulation and inhibition of fi brinolysis in the lungs similar to what is known to occur in community- acquired bacterial pneu monia and acute respiratory distress syndrome? If so, does activated ... al.,unpublished data). A possible downside to thrombin inhibition by anti- coagulation agents is the loss of the ability to wall off infection through fi brin formation. Fortunately...

Ngày tải lên: 13/08/2014, 20:22

... average cytosolic calcium concentration is an adequate approximation to the rapid oscillatory responses. Finally, we note (Stanislaus et al, [34]) that there is evidence that the GnRH receptor inter- acts ... Figure 15, Panel A). They attributed this rapid desensitization in part to rapid internalization of the ET receptors (see also Stojilkovic et al. [27]). To test this hypothesis...

Ngày tải lên: 13/08/2014, 22:22

... fluorophores account for the previous, the cur- rent or the next base to be sequenced (Figure S2 and Table S2 Analysis of mismatchesFigure 2 Analysis of mismatches. Analysis of mismatches seen for (a) Bustard ... cycle 25, guanine is mistaken as thymine. In later cycles adenosine and cytosine are also mistaken as thymine, due to increasing T accumulation. The error rate of the last...

Ngày tải lên: 14/08/2014, 21:21

... 11.8 yrs, 2 were current smokers, 30 (52%) had a history of atopy, 11 (19%) were on inhaled corticosteroids before exacerbation, and 19 (33%) had a recent history of acute upper respiratory infection. ... 18 yrs; 2) history of typical bronchial asthma > 6 mo and 3) smoking his- tory < 10 pack/yrs. Patients with a radiological diagnosis of pneumonia or with impaired consciousness on admi...

Ngày tải lên: 12/08/2014, 15:21