Báo cáo y học: "Dexamethasone inhibits IL-9 production by human T cells" doc

... that may be stimulated by the PLFs were present and con- tributed to our findings, and it may be argued that the complexity of this in vivo system makes it difficult to inves- tigate all potential ... membrane may potentially provide an explanation. It has been suggested that ATPases contribute to the H + secretion not only by osteoclasts [29] but also by other cells, including tubular...

Ngày tải lên: 09/08/2014, 01:21

... it very likely that the observed effects directly involve helper T cells. The data indicate that CD4+ T cells produce substantial amounts of IL-9, although the possibility that other cells in ... real-time data. In the samples activated with OKT3, a single strong band was detected with apparent mobility consistent with the predicted fragment size of 277 bp (Fig. 1B). After treat- ment w...

Ngày tải lên: 11/08/2014, 08:21

... inflammation. A growing body of evi- dence suggests that many cell types present in asthmatic airways have the capacity to gen- erate RANTES, which directly supported the potential role of RANTES ... Schall TJ, Bacon K, Toy KJ, et al. Selective attraction of monocytes and t lymphocytes of the memory phenotype by cytokine rantes. Nature. 1990; 347: 669-71. 25. Kuna P, Reddigari SR, Scha...

Ngày tải lên: 26/10/2012, 09:39

... recruit inflammatory cells within the CNS. Conclusion Taken together, the findings in this study support the hypothesis that morphine stimulates CCL2 expression by human neurons and add another ... conflict of interest with the current study. Authors' contributions RBR participated in the design of the study and was responsible for writing the manuscript. SH carried out the isolation...

Ngày tải lên: 19/06/2014, 22:20

... collected for 10 4 lymphocytes. Positively and nega- tively stained populations were calculated by quadrant dot plot analysis determined by isotype controls. Statistical analysis A non-normal distribution ... memory T cells might favor the recruitment of Th1-type effector memory T cells into granulomatous lesions of the respiratory tract, whereas in generalized WG the CCR3-mediated re...

Ngày tải lên: 09/08/2014, 01:21

... and the corresponding healthy control group (P > 0.9, by Student’s t- test), between the age of the SLE patient group and the corresponding healthy control group (P > 0.9, by Student’s t- test), ... t- test), and between the RA patient group and the SLE patient group (P > 0.5, by Stu- dent’s t- test). Table 1 Patient profiles and characteristics Patient number/ Disease sex/...

Ngày tải lên: 09/08/2014, 01:21

... while the other dominant subset was clearly restricted (Figure 4c). Two patients did not display any of these distinct patterns of TCR-Vβ distribution. In all 13 patients, the distribution of TCR-Vβ ... investigated with regard to antigen specificity and selective recruitment to the joint. Materials and methods Patients One hundred and twenty-eight patients with RA were enrolled in the study....

Ngày tải lên: 09/08/2014, 10:21

... inhibit the activity of a transcriptional factor such as JunB by sequestration to HBZ-NBs. HBZ is known to affect tran- scriptional activity differently depending on its het- erodimerization partner. ... transcrip- tional activity. Taken together, these results clearly dem- onstrate that HBZ-mediated sequestration of JunB to these particular subnuclear structures may result in repres- sion...

Ngày tải lên: 13/08/2014, 09:20

... well as the binding to cyclin T1 as crucial elements for efficient Tat inhibition. Results Tat activity is inhibited by HEXIM1 Tat activity involves direct interaction with CDK9/ CyclinT1 (P-TEFb) ... pre- sented in Fig. 1C we found that, while hCycT1 rescued Tat function, ectopic expression of HEXIM1 effectively inhib- its Tat activity. Most importantly, Tat enhancement medi- ated by hC...

Ngày tải lên: 13/08/2014, 09:21

... end-protective protein targeted by Tax. Tar- geting of DNA end-protective proteins by oncoproteins may attenuate the functions of these factors and could lead to increased DNA structural instability ... viral Tax oncoprotein to the list of complex interactors with Ku. We report here that cells genetically knocked out for Ku80 are refractory to the induction by Tax of MN and DIG-dUTP inc...

Ngày tải lên: 13/08/2014, 09:21