Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot

... Central Page 1 of 7 (page number not for citation purposes) Journal of Inflammation Open Access Research The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles Susan ... viability in all types of muscle. Conclusion: These results show that in skeletal muscle, IR injury is dependent upon both the presence of...

Ngày tải lên: 11/08/2014, 08:21

... participate in left ven- tricular remodelling. These and other inflammatory cells release TNF-α and interleukin-6, thereby increasing CRP lev- els through upregulation of hepatic synthesis [27]. The ... data from the 10-year follow-up examination, which gave the oppor- tunity of controlling not only for cardiovascular risk factors, including body mass index (BMI) and creatinine...

Ngày tải lên: 09/08/2014, 10:23

... Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergisti- cally induced production of interleukin-8 ... taken into account in lung infec- tion. Besides the signaling pathways mentioned, other path- ways, including e.g. tyrosine kinases [197] or protein kinase C [198], may also play an impor...

Ngày tải lên: 12/08/2014, 16:20

... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unitary free...

Ngày tải lên: 17/03/2014, 10:20

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To ... (k cat /K m )forp-hydroxyphenylgly- cine methyl ester and phenylglycine methyl ester that were similar to the wild -type values, whereas the specificity con- stants for p-hydroxyphen...

Ngày tải lên: 17/03/2014, 23:20

... sulfur ligands in the Cys239 fi Ala and an increased number of sulfur ligands in His237 fi Ala (in comparison to the wild -type enzyme). As a model for the zinc in the absence of any sulfur ligand we ... indicating that, in the absence of coenzyme M, zinc is probably coordinated by a single sulfur ligand and three oxygen or nitrogen ligands. In the presence of coenzyme M...

Ngày tải lên: 17/03/2014, 23:20

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain (Arg266). The resul...

Ngày tải lên: 18/03/2014, 01:20

... delivery. The frequency of developing atopic dermatitis in the offspring was significantly reduced by 2, 4, and 7 years [26-28], by 50%, 44%, and 36% respectively. Similar studies have yielded ... in Estonian and Swedish infants. Clin Exp Allergy 2005, 35(2):153-9. 12. Bjorksten B, et al.: Allergy development and the intestinal microflora during the first year of life. J Aller...

Ngày tải lên: 08/08/2014, 21:20

... critical role of COX-2 in mesenchymal cell differentiation during skeletal repair. Using COX-1-null and COX-2-null mice, they demon- strated the essential role of COX-2 in both endochondral and intramembranous ... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have...

Ngày tải lên: 09/08/2014, 01:21

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... intracellular domain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notably contain ankyrin repeat motifs con...

Ngày tải lên: 09/08/2014, 01:22