Báo cáo khoa hoc:" Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression" potx

... number not for citation purposes) Journal of Negative Results in BioMedicine Open Access Research Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma ... combined into a single variable, the 'phe- notypic index' [17]. This index, with minimum and max- imum values of 1 and 5, represents the...

Ngày tải lên: 11/08/2014, 08:21

... between the N-terminal and C-terminal NBD in this region are highlighted in ball -and- stick fashion in Fig. 5B. The first is the presence of an asparagine (Asn428) in the Walker-A motif of the N-terminal ... derivatization, and (b) occupancy of the nucleotide-binding site could alter the accessibility and reactivity of this cysteine. Therefore, the puri...

Ngày tải lên: 08/03/2014, 08:20

... normal individuals) because of their inability to repair UV-induced DNA lesions. These clinical findings are associated with cellular defects, including hypersensitivity to killing and the mutagenic ... high-throughput genotyping methods will facilitate the analysis of multiple polymorphisms within genes and the analysis of multiple genes within pathways. The ef...

Ngày tải lên: 31/10/2012, 14:59

... two elements in ClpA, one in the N-domain and the other in the pore of the ClpA hexamer. In the case of short unstructured peptides or unfolded proteins such as casein, binding to the tyrosine residues in ... three domains: an N-domain and two ATP-binding domains referred to as the D1 and D2 domains. Interestingly, deletion of the N-domain from ClpA not...

Ngày tải lên: 07/03/2014, 05:20

... 3. The nominative form is identical to the ac- cusative in the feminine singular of der and welcher, in the neuter singular of der, welcher and was, and in the plural (all genders) of der and ... need not continue to discuss the solution of these first two types, since it will be contained in that of the main problem, the distinction of nomi...

Ngày tải lên: 07/03/2014, 18:20

... ([Ile8]oxytocin) are the evolutionary precursors of oxytocin [1]. The receptors that mediate the effects of these hormones are G-protein coupled receptors (GPCRs) and include the isotocin receptor, the ... off-state. The unique ability of arginyl to fulfil this constraining function in the N-terminus of the V 1a R is similar to the unique constraining role of...

Ngày tải lên: 07/03/2014, 21:20

... of analogs in the active center. Furthermore, these findings also seem to indicate that the analogs can Fig. 5. Scheme of the HDC reactions with the natural substrate histidine and the histidine- analogs ... 5 min, the spectra of the HisOMe-treated samples had stabilized with the 390-nm peak as the major and final one. In the reaction in the presence o...

Ngày tải lên: 08/03/2014, 08:20

... role in stabilizing the DNA–drug complex. The NH amide atoms of the drug in particular form H-bonds with thymine O2 and adenine N3 atoms in the AATT-rich sequence of the decamer. Part of the spine ... cataloging the structure to class I. As the bulky NH 2 group on guanine was believed to prevent binding of the drug in the minor groove, the detailed na...

Ngày tải lên: 16/03/2014, 22:20

... occurred in the last two decades. Surgeons, once solely interested in the extipartion of the primary tumor, are now faced with the need to incorpo- rate a great deal of information, and to manage increasingly ... considered standard of care for these tumors. Although either multiple Tc-99 injections or a single intradermal injection over the largest-size lesion has b...

Ngày tải lên: 09/08/2014, 03:21

... report. Competing interests The author(s) declare that they have no competing inter- ests. Colour images of perfluorodecalin residue in anterior cham-ber of a 17-year-old male with an intact crystalline ... the retina before and after operation. (a and b) Giant retinal tear with shallow detached retina involving the macula in the right eye. (c) Reattachment of retin...

Ngày tải lên: 11/08/2014, 10:23