Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren''''''''s Disease" doc

Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren''''s Disease" doc

... of Wnt expression is highly variable in this fibroproliferative dis-ease with the only consistent finding being down-regu-lated Wnt 11 mRNA expression in disease tissue. As Wnt- 11 signalling ... axinbinding protein diversin [33], phosphorylates β-catenin atserine 45, an important priming step required by GSK-3βto mediate β-catenin phosphorylation at threonine 41,serine 37 and serine ... DNA binding proteins[21,22].The importance of the Wnt/ β-catenin signalling is under-scored by its targeted disruption in human diseases. Forexample, several members of the Wnt/ β-catenin pathwayare...

Báo cáo khoa hoc:" Sporadic ALS is not associated with VAPB gene mutations in Southern Italy" ppt

... (SALS), not showing any familial trait. Approximately 10% of casesare familial (FALS), and within these lie several distinctforms of the disease. The most common form of FALS is autosomal dominant ... muta-tions in this gene are a rare cause of non familial forms ofALS [14,15].The finding by Nishimura et al.[16] of a missense muta-tion in the VAMP/synaptobrevin-associated membraneprotein B ... membraneprotein B (VAPB) gene in autosomal dominant motoneu-ron diseases (ALS8), prompted us to investigate the entirecoding region of this gene in 125 SALS patients.Following informed consent, blood...

Báo cáo khoa học: " 3-D reconstruction of anterior mantle-field techniques in Hodgkin''''s disease survivors: doses to cardiac structures" pptx

... structures in mediastinalradiotherapy has rarely been investigated. As part of an interdisciplinary project, the 3-D dosedistribution within the heart was reconstructed in all long-term Hodgkin's ... ongoing interdisciplinary study between cardi-ologists, radiologists and radiation oncologists, Hodg-kin's disease survivors will be invited for extensivecardiologic tests including cardiac ... radiation-induced late tox-icity, of which heart disease is one aspect, oncologists andcardiologist are still seeing survivors of Hodgkin's diseasetreated in earlier decades, e. g. with extended-field...

báo cáo khoa học: " The role and challenges of the food industry in addressing chronic disease" docx

... innovation.Greater R&D intensity is one route to the disruptiveinnovation critically needed in the food industry. R&Dintensity is a well-established indicator of industry inno-vation[21]. The pharmaceutical ... above in addition, not IFBA members have increased investments in R&D aimed at achieving this and each of the companies employ scientists, nutritionists and engineers to develop innovative ... many independent monitoringschemes that include the Dow Jones Sustainability Indexand the Global Reporting Initiative[29]. Their reports tothe investor and business community create incentivesfor...

Báo cáo khoa hoc:" Preprandial ghrelin is not affected by macronutrient intake, energy intake or energy expenditure" docx

... appetite is increased [10]. Interestingly, it hasalso been shown that fasting ghrelin is negativelyassociated with energy intake [25]. In this same study[25], Caucasians had ghrelin concentrations ... young women indicated that ghrelin increases in response to an exercise regimen, but only when exerciseinduces weight loss. Therefore, it appears that ghrelin is not influenced by changes in energy ... essential amino acids in humans. J Endocrinol 2003,179:237-244.13. Knerr I, Groschl M, Rascher W, Rauh M: Endocrine effects of foodintake: insulin, ghrelin, and leptin responses to a single bolusof...

Báo cáo khoa hoc:" Perigraft air is not always pathological: a case report" docx

... in the early postoperative phase is probably a normalfinding, is not associated with graft infection and can be managed non-operatively.BackgroundIntra-abdominal free gas is a normal finding ... gas later in the postoperativeperiod following abdominal aortic aneurysm repair is not such a benign finding and is said to be a reliable indicatorof graft infection. This complication is associated ... that had not completely resolved. Another option is that this mayhave been indicative of a subclinical infection althoughthis is less likely as no infection has become evident dur-ing 2 years...

Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx

... and with iron. Thin linesrepresent background staining with mouse Igs. (B) Histogramsshow background staining with no antibody (thin lines) or with rab-bit Igs (thick lines) as ﬁrst step in ... asdetermined by the increase in mean ﬂuorescence inten-sity (MFI) (Fig. 1C). As shown in Fig. 1B, permeabili-zation with saponin did not increase backgroundstaining when rabbit immunoglobulins ... thatthe increase in the prooxidant state caused by ironloading has an impact in protein integrity, as indicatedby an increase in protein-bound acrolein adducts atthe cell surface, which point...

Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx

... polymerase, is involved in cytoplasmicpolyadenylation in Xenopus oocytes. In this study, a new XGld2-interactingprotein was identiﬁed: Xenopus RNA-binding motif protein 9 (XRbm9).This RNA-binding ... that are characteristic of RNA-bindingproteins, and an alanine-rich carboxy-terminal sequencethat could be involved in protein–protein interactions.Interestingly, this alanine-rich sequence, ... proteins with Gal4BD and Rbm9 con-structs were expressed as fusion proteins with Gal4AD. Double transformants growingon medium lacking tryptophan, leucine andhistidine, indicating an interaction,...

Báo cáo khoa học: Gene expression waves Cell cycle independent collective dynamics in cultured cells doc

... ‘stealing’ phases relative to someextracellular protein needed by the colony as a whole.An intriguing candidate is the lectin-like proteininvolved in ﬂocculation, a cell wall protein that bindsto ... the elutria-tion set. This ﬁnding is in accordance with the hypo-thesis of a coupling between the duration of themetabolic and reproductive cycles [1–6], even if in thiscase we demonstrated ... ofthe tissue to be put into operation. This coordinationcan be achieved in a number of ways (e.g. hormonal,nervous and neuroendocrine signalling). However, nosimilar observation was made in the...

Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx

... identical. Onprotein level ﬁve amino acids located near the N-terminusare missing in the rat VRL-1 as compared to its mouseorthologue. Unfortunately it is not possible to distinguishbetween the ... mousevariant is derived from the F-11 parental cell line N18TG2.This ﬁnding is of interest when VRL-1 is functionallystudied in these cells. Additionally in this study we clonedVRL-1 from total RNA isolated ... Laboratories) as second antibody. Nuclei werestained with 0.0004% 4¢-6-diamidino-2-phenylindole-2HCl(DAPI) for 3 min before mounting. Immunostaining wasvisualized using ﬂuorescence microscopy.Preparation...

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