Báo cáo khoa hoc:" Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson''''''''s disease in two European populations" pps

... PD. In this population-based study, we investigated whether sequence variations in the PINK1 gene play a role in the late-onset form of PD. A recently described variation (Q115L) of the PINK1 gene ... mutation screening. Conclusion Investigations of other genes involved in the mitochon- drial pathway of the PINK1 gene are necessary to evaluate the e...

Ngày tải lên: 11/08/2014, 08:20

... measurements of the reference ceramic then 32 measurements of the sample) was obtained for each sample. The absorbance spectrum, represented as a log value(1/R), was ob - tained by averaging these ... LGS measurement was obtained, on the same longitudinal axis at the pe- riphery of the tree. Chemical analyses and shrinkage measurements were performed on these extreme str...

Ngày tải lên: 08/08/2014, 14:20

... HAD inhibitors. To check for covalent modifications of the enzyme, the effect of the inhibitor on the molecular mass value of HAD was measured; instead of an adduct increase, or no change, the ... destroys the information on the size of the protein and the connectivities of the pep- tide fragments, but it has no size limit for protein digestion. In contras...

Ngày tải lên: 18/02/2014, 16:20

... 10 min. The affinity of elastin for NE or Pr3 was assessed by adding a constant concentration of enzyme to increas- ing concentrations of elastin, stirring for 10 min, centrifugating the suspensions ... suppress the elas- tase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro. J Clin Invest. 66, 987–995. 24 Bieth JG (1984) In vivo significance of kinetic const...

Ngày tải lên: 19/02/2014, 07:20

... synthesis. In this type of synthesis, units of recorded speech are appended. By using recorded speech, many of the voice qualities of the person recording the speech remain in the resulting ... segments of speech. Appending larger the units of speech results in smoother, more natural sounding synthesis, but requires many hours of recording, often by a traine...

Ngày tải lên: 20/02/2014, 09:20

... protein band, thus pointing to the absence of a covalently bound flavin moiety in the recombinant product. Moreover, as in the case of the plant l-galactono-1,4-lactone dehydrogenase [12], the ... cell signaling. L-AA is therefore involved in a wide array of crucial physiologic processes, including: biosynthesis of colla- gen and other hydroxyproline ⁄ hydroxylysine-c...

Ngày tải lên: 07/03/2014, 12:20

... multifunctional protein that plays a key role in binding chitin, and thus in participating in the structuring of the organic framework, at the same time as finely interacting with the mineral phase. It is ... be essential for the control of the biomineral formation [1]. In particular, it is assumed to interact in different ways with the mineral phase at the na...

Ngày tải lên: 22/03/2014, 16:20

... underspecifi- cation formalism can be compact, i.e. in the worst case, the USR of a set of readings become exponen- tially large in the number of scope-bearing operators. In the case of RTGs, this worst case ... dis- joint, i.e. neither dominates the other. We take the hard backbone of D to be the ordinary dominance graph B(D) = (V, E T  E D ) obtained by removin...

Ngày tải lên: 23/03/2014, 17:20

... trig- gering receptor kinase activity and signaling pathways involving the binding of ezrin to ezrin–radixin–moesin proteins, and thus actin cytoskeleton binding and Ras activation. HGF elicits metastatic ... [22,23]. The rather short cytoplasmic tail of CD44 binds to ankyrin and ezrin–radixin–moesin proteins, providing a link to the cytoskeleton, as well as to merlin, which abr...

Ngày tải lên: 28/03/2014, 23:20

... with these findings, CT26 cancer cells significantly increased LFA-1 expression in non- hypoxic avascular micrometastases at their earliest inception within hepatic lobules in vivo; and angiogenesis ... not for citation purposes) Background During the earliest stages of the hepatic metastasis proc- ess, microvascular arrest and residency of disseminated cancer cells results in...

Ngày tải lên: 18/06/2014, 15:20