Báo cáo khoa hoc:" Vitamin D receptor gene polymorphisms in multiple sclerosis patients in northwest Greece" docx

... steroid binding receptor (MARRS) [8]. Certain polymorphisms of the VDR gene may modify vitamin D function and metabolism and have been exam- ined in studies evaluating the role of vitamin D on ... osteoporosis. We examined the frequency of the Taq-I and Bsm-I polymorphisms of the vitamin D receptor (VDR) gene in 69 patients with MS and 81 age and sex-matched heal...

Ngày tải lên: 11/08/2014, 07:21

... radiographs' readings. HR conceived of the study and participated in its design. PLA conceived of the study and par- ticipated in its design and coordination. All authors read and approved ... unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Abstract We examined whether polymorphisms of the vitamin D receptor (VDR) gene...

Ngày tải lên: 09/08/2014, 07:20

... and murine lupus [2]. It has been demonstrated that patients with SLE have a lower level of 25 hydroxyvitamin D3 than do healthy controls [3]. In addition, high-dose 1,25-dihydroxyvitamin D3 ... purposes) droxyvitamin D3 directly inhibits synthesis and secretion of IL- 2 [15,16] and IFN-γ [17,18] and also inhibits immunoglobulin production [19]. Genomic actions of 1,25-dihydroxyvitamin...

Ngày tải lên: 09/08/2014, 07:20

... conditions. Patients and methods We recruited 45 patient with DDH and 20 patients with PPA. In all patients, a diagnosis of DDH or PPA was made on the basis of clinical and radiographic examination. ... hip (DDH) and primary protrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu II and Xba I. 45 patients w...

Ngày tải lên: 11/08/2014, 08:21

... PI, propidium iodide; PTEN, phosphatase and tensin homolog deleted on chromosome 10; siRNA, small interfering RNA; TSA, trichostatin A; VD3, 1,25-dihydroxyvitamin D 3; VDR, vitamin D receptor. FEBS ... active form of vitamin D, 1,25-dihydroxyvitamin D 3 (VD3), belongs to the secos- teroid hormone family, which controls calcium and Keywords 1,25-dihydroxyvitamin D 3 ; 5-aza-2¢-...

Ngày tải lên: 22/03/2014, 21:20

... maintained in 10% fetal bovine serum-supplemented Dulbecco’s modified Eagle’s medium (DMEM) (Hyclone, Logan, UT, USA); MDA-MB-231 cells were maintained in 10% fetal bovine serum-supplemented L-15 ... elevated by inhibiting endogenous miR-22 in MDA-MB-231 cells (Fig. 2F). Interestingly, the reduc- tion in ERa protein levels was markedly greater than the reduction in ESR1 mRNA levels d...

Ngày tải lên: 22/03/2014, 21:20

... identified including three TFs of the B3 DNA- binding domain family, namely ABSCISIC ACID INSENSITIVE3 (ABI3), FUSCA3 (FUS3) and LEAFY COTYLEDON2 (LEC2), and a HAP3 subunit of the CCAAT-box binding ... associated with soybean genes coding for dif- ferent subunits of glycinin, β-conglycinin or 7S globulin (Table 2). Similar results were obtained in Arabidopsis and rice (Additional file 2), w...

Ngày tải lên: 12/08/2014, 03:21

... QTL, allowing for non-additive effects at the QTL, including dominance, epistasis and gametic imprinting. The method derived here was applied t o optimizing selection on two linked QTL in a companion ... the mean breeding value of individuals with QTL geno- type m in generation t,and  BV ijmt is the individual’s polygenic breeding value estimate. In the index,  BV ijmt is deviated fro...

Ngày tải lên: 09/08/2014, 18:21

... 0.74 0.49 a The 12 -gene set includes HLA -DRB1 and 11 additional validated susceptibility genes. b The 350 -gene set includes HLA-DRB1 and 349 additional genes identified in the genetic profile. Table ... marker showed an independent effect in addition to the preceding markers that were alreadyplacedinthemodel.Thesecondtestsoughtto examine multicollinearity in between markers due to...

Ngày tải lên: 11/08/2014, 12:21

... manuscript. EA coordinated data collection and contributed to the manuscript. SO coordinated data collection and con- tributed to the manuscript. HK coordinated data collection and contributed to the manuscript. ... Petter- son et al found that patients with longer diabetes dura- tion were generally more depressed and lacking in energy, positive well-being, and general well-being [15]. We...

Ngày tải lên: 12/08/2014, 01:21