Báo cáo khoa hoc:" Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat" docx

... of Negative Results in BioMedicine Open Access Research Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat Eric C ... age-related hearing loss in the Fischer 344/NHsd rat can be altered with systemic administration of ALCAR. Background The Fischer 344/NHsd (F...

Ngày tải lên: 11/08/2014, 07:20

... mechanism involving the N -acetyl group of the sugar bound to the )1 subsite. We have studied the degradation of the soluble heteropolymer chitosan, to obtain further insight into catalysis in ChiB ... regardless of the initial binding mode, leading to the observed initial domin- ance of even-numbered oligomers. Interestingly, the initial formation of even-numbered ol...

Ngày tải lên: 07/03/2014, 16:20

... experiments. The NETtalk dic- tionary was originally developed with the L2P task in mind. The syllabification data in NETtalk was created manually in the phoneme domain, and then mapped directly to the ... percentage on the letter -to- phoneme task with and without the syllabification infor- mation. To measure the improvement syllabification can effect on the L2P...

Ngày tải lên: 17/03/2014, 02:20

... provide support in our lexical definition tools (KNACQ) for specifying them. In KNACQ [15], a knowledge engineer, data base administrator, or other person familiar with the domain and with frame ... accomplished by enabling the user to state information needs without specifying how to decompose those needs into a program calling the various underlying systems required...

Ngày tải lên: 31/03/2014, 18:20

... seem to point out that the S loop, known to be involved in the cofactor-binding site, may also be essential for the interaction be tween GAPDH and CP12. Previous attempts to reconstitute the topology of ... essential for the binding of CP12. The presence of this region at the interface of GAPDH and CP12 could also explain the kinetic changes o bserved for the binding...

Ngày tải lên: 19/02/2014, 16:20

... of the domains in the crystal; the PYR domain has the lowest average B-factor, 23 A ˚ 2 (comparable to the B-factor of bound ThDP), whereas the middle domain has the highest overall B-factor, 37 ... decarboxylase, suggesting that the interactions with the cofactor thiamin diphosphate and the catalytic mechanisms are very similar. The substrate binding site in ind...

Ngày tải lên: 20/02/2014, 11:20

... rder to construct an interface be- tween the learnt policies for COMMUNICATO R and the in- car baseline system. 5.2 Mapping between COMMUNICATOR and the In- car Domains There are 2 main problems to ... policy to new do- mains – for example the in- car do main. In the in- car scenarios the genre of “information seeking” is central. For example the SACTI corpora (Stutt...

Ngày tải lên: 22/02/2014, 02:20

... partner, RXR (retinoid-X-receptor), and are subject to cross talk interactions with other nuclear receptors and with a broad range of other intracellular signaling pathways [21,22]. The purpose of ... activity and then transforms this intermediate into DHEA through its 17,20-lyase activity. In order to deter- mine whether the transformation of preg into androstadie- nol requires...

Ngày tải lên: 08/03/2014, 08:20

... onsidered to be realistic. The interproton distances involving the exchangeable protons in the H 2 O NOESY spectra are restrained to the ranges 2–4 A ˚ and 3.5– 5.5 A ˚ , corresponding to the s trong ... interproton base to sugar NOEs in the NOESY spectrum (Fig. 3C), at mixing times varying from 70 to 300 m s, indicate that the 5¢-terminal guanine exists in the...

Ngày tải lên: 16/03/2014, 18:20

... resent study, together with the previous work described by Concha et al. [8], offers promising evidence that they might. Certainly there is no reason why apolipoproteins in the skin secretion ... were caught in th e C ayumapu river ( Province of Valdivia, Chile) and maintained in an outdoor tank with running river water. Fish weighing Correspondence to M. I. Concha, Instituto...

Ngày tải lên: 16/03/2014, 18:20