Báo cáo y học: "Probable tacrolimus toxicity from tibolone co-administration in a woman: a case report" pdf

... ator- vastatin 20 mg daily, alendronate 70 mg weekly, ome- prazole 20 mg daily, citalopram 20 mg daily, calcium carbonate 600 mg daily, calcitriol 0.25 μg daily and folic acid 5 mg daily. The only change ... tacrolimus toxicity from tibolone co-administration in a woman: a case report. Journal of Medical Case Reports 2010 4:276. Submit your next manuscript to BioMed Cent...

Ngày tải lên: 11/08/2014, 03:21

... tacrolimus toxicity from tibolone co-administration in a woman: a case report. Journal of Medical Case Reports 2010 4:276. Submit your next manuscript to BioMed Central and take full advantage of: ... in the liver and the gut by CYP 3A4 and CYP 3A5 isoenzymes to several metabo- lites. Tibolone is rapidly metabolized to its three meta- bolites in the gastrointestina...

Ngày tải lên: 11/08/2014, 07:20

... was managed conservatively, the patient’s recovery was sustained. She was finally discharged home well 26 days after admission. Discussion The striking feature of this case was the severity and duration ... drug accumulation and increased toxicity or reduced efficacy of one or both drugs. In the absence of pharmacokinetic interactions, the two drugs may still produce clinically relevant...

Ngày tải lên: 11/08/2014, 14:20

... control (a) . Mesenchymal marker F-actin, was faintly stained at the cell margin in the control (c), whereas the staining was substantially enhanced and abundantly located throughout cytoplasm after ... Costantini, Department of Genetics, Columbia University, NY, USA) using the following primers: forward 5'- GAAGATCTATGCCCAAGAAGAAGAGGAAGGTGTC- CAATTTACTGAC-3' and reverse 5'...

Ngày tải lên: 12/08/2014, 16:20

... matrix components, facilitating binding of autoantibodies to capillary and mesangial antigens. This maintains the inflammatory reaction and continued stimulation of matrix degradation, leading to disruption ... important factor in initiating end organ manifestations of an autoimmune response. Identifying the signalling pathways that are involved in inducing the observed alterations in M...

Ngày tải lên: 09/08/2014, 13:22

... Epidemiology Project resources [28,29]. This linked medical-records system allows access to accurate and detailed clinical and laboratory data over many years, which are not typically available in other ... peripheral arterial disease in predicting adverse cardiovascular outcomes (myocardial infarction, stroke, and death). Am J Cardiol 2005, 96:1374-1378. 23. Gonzalez-Gay MA, Garcia-Porru...

Ngày tải lên: 09/08/2014, 14:20

... different loca- tions within the periphery of the tumor bed. Case presentation Our patient was a 37-year-old Caucasian male who was initially diagnosed 12 years ago with a World Health Organization ... oligodendroglioma: a case report Shannon Fogh 1* , Charles Glass 2 , David W Andrews 3 and Maria Werner-Wasik 2 Abstract Introduction: High grade gliomas are an insidious disease asso...

Ngày tải lên: 11/08/2014, 00:23

... sponta- neous age-related emphysema that was associated with increased oxidant stress, cell death, and elastolytic activ- ity. A detailed mechanistic analysis showed that TLR4 maintains a critical ... cytoplasmic signaling machinery [5]. MyD88 was initially identified as part of the interleukin (IL) -1R and IL-18R signalling pathways and was subsequently implicated in signal ling by alm...

Ngày tải lên: 11/08/2014, 03:20

... infections, meningitis, intra- abdominal infections and bacteraemia. Case presentation: We report a case of Lactobacillus casei bacteraemia in a 66-year-old immunocompetent man with a history of fever ... permeability states [11]. Bacteraemia caused by probiotic organisms is rare but underestimated, since they are normally regarded as con- taminants and their role as primary invad...

Ngày tải lên: 11/08/2014, 21:22

... of angiotensin-converting enzyme (ACE) 2 activity by 5 μg purified IgG was examined in triplicate assays. As a control, ACE2 activity in standard rACE2 was measured in the absence of IgG. As ... pulmonary arterial hypertension. Chest 2006, 130:182-189. 17. Tanaka E, Harigai M, Tanaka M, Kawaguchi Y, Hara M, Kamatani N: Pulmonary hypertension in systemic lupus erythematosus: eval...

Ngày tải lên: 12/08/2014, 12:20