Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are

Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx

... pretreatment results in an inhibition of inflammatory signaling in cells with CF defects. Production of IL-8 and other pro-inflammatory cytokines is also governed by mechanisms regulating in their mRNA ... extracellular-regulated protein kinase (ERK) cascades are active by phosphorylation through dual specificity MAPK kinases (MKK) and may all contribute to IL-8 expre...

Ngày tải lên : 11/08/2014, 03:20

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Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation potx

... Epac, may instead activate a tyrosine phosphatase which results in the observed decrease in both basal and CSF-1-induced tyrosine phosphorylation. In contrast to the data for EGFR-dependent tyrosine ... monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine monophosphate. Blood 79, 1972–1981. 9 Vairo G, Argyriou S, Bordun AM, Whitty G & Hamil...

Ngày tải lên : 16/03/2014, 22:20

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Báo cáo y học: "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood" ppt

... bone marrow cavity in chronic inflammatory arthritis. Introduction TNF is a clinically validated etiological factor in inflammatory- erosive arthritis and is known to synergize with RANKL and macrophage ... in inflammatory osteolysis. Arthritis Res Ther 2006, 8:201. 2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone di...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx

... F, Ficheux H, Pujol JP: Rhein inhibits interleukin-1 beta-induced activation of MEK /ERK pathway and DNA binding of NF-kappa B and AP-1 in chondro- cytes cultured in hypoxia: a potential mechanism ... growth factors, cytokines, proteases, and inflammatory mediators. The levels of alkaline phosphatase, osteocalcin, type I collagen, interleukin (IL)-6, transforming growth factor-...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot

... signals in macrophages [7]. The two pro- inflammatory enzymes, induciblenitricoxidesynthase (iNOS) and cyclooxygenase-2 (COX-2), which can be induced by LPS or cytokines, are found to work in concert in ... the production of inflammatory cytokines, chemokines, and proinflamma- tory enzymes (e.g. iNOS and COX-2) [38-40]. The pro- moter of the iNOS and COX-2 genes are know...

Ngày tải lên : 10/08/2014, 05:21

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Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"

... prepared using heated processing conditions to substantially inactivate hemagglutinat- ing activity (HA) and trypsin inhibiting activity (TIA) while preserving alpha-amylase inhibiting ability. ... to follow the nutritionist’s recommendations. The candidates were entered into a 2-week single-blinded, run -in to en- rollment and randomization. Subjects in this run -in period...

Ngày tải lên : 31/10/2012, 15:12

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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the C-SH2 domain [17]. Experiments with Gab1 mutants which are unable to bind to SHP-2 indicate ... bisphosphoryl tyrosine-based activation motif (BTAM) that binds to and activates SHP-2 [17]. Two SH2 domaines of SHP-2, termed N-SH2 and C-SH2 domaines, are...

Ngày tải lên : 31/10/2012, 15:37

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Tài liệu Báo cáo Y học: A novel meta-cleavage dioxygenase that cleaves a carboxyl-groupsubstituted 2-aminophenol Puriﬁcation and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d doc

... nitrogen and energy source. 4-Amino-3-hydroxybenzoic acid was meta- bolized via 2-amino-5-carboxymuconic 6-semialdehyde to 2-hydroxymuconic 6-semialdehyde by Bordetella sp. strain 10d (Fig. 4A, and ... 4-amino-3-hydroxybenzoate cleavage. I, 4-amino-3-hydroxybenzoic acid; II, 2-amino-5-carboxymuconic 6-semialdehyde; III, 2-hydroxymuconic 6-semialdehyde; IV, 2,5- pyridinedicarboxylic acid...

Ngày tải lên : 21/02/2014, 01:21

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Báo cáo khoa học: Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding Pallavi Srivastava and Dulal Panda ppt

... microtubules in vitro. It also inhibited the binding of colchicine to tubulin, perturbed the secondary structure of tubulin, and reduced the intrinsic tryptophan fluorescence of tubulin and the extrinsic fluorescence ... cell viability probes compatible with fixation and permeabi- lization for combined surface and intracellular staining in flow cytometry. Cytometry 19, 243–255. 23 R...

Ngày tải lên : 07/03/2014, 05:20

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Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" pdf

Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx

Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation potx