Báo cáo y học: "Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts" pot
Báo cáo y học: "Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts" pot
... abnormalities in the kynurenine pathway of tryptophan degradation.Keywords: human, fibroblast, kynurenine pathway, gene expression, cytokineIntroductionThe kynurenine pathway (KP) is the main route of ... AccessEffects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblastsLinnéa Asp1, Anne-Sofie Johansson1, Amandeep Mann1, Björn Owe-Larsson2, Ewa M ... rate-limiting step of this pathway and is highly induced by the pro-inflamma-tory cytokine interferon (IFN)-g [22,23]. However, it isnot clear if pro-inflammatory cytokines affect expression of genes...
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Báo cáo y học: " Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts" pdf
... studies of disease-related abnormalities in the kynurenine pathway of tryptophan degradation.Keywords: human, fibroblast, kynurenine pathway, gene expression, cytokineIntroductionThe kynurenine pathway ... 8:25http://www.journal-inflammation.com/content/8/1/25Page 7 of 7RESEARCH Open AccessEffects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblastsLinnéa Asp1, Anne-Sofie Johansson1, Amandeep ... transcripts encoding enzymes in the kynurenine pathway in human skin-derived fibroblasts from 7individuals. Transcripts encoding the following enzymes wereinvestigated; Indoleamine 2,3-dioxygenase 1...
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Tài liệu Báo cáo Y học: Purification, characterization, cloning, and expression of the chicken liver ecto-ATP-diphosphohydrolase pot
... hydrolysis by 70% whereasATP hydrolysis was inhibited by only 10%. Inhibition of ADP and ATP hydrolysis by azide was greater when the pH of assay solutions was 6.4. Azide inhibition was diminishedif ... chromatogra-phy buffer, buffer containing 0.5MNaCl, and buffer again.The enzyme was eluted with 50 mMglycine, pH 2.5containing 0.1% NP-40. Fractions of 1 mL were collectedinto tubes containing 0.1 ... five apyrase conserved regions (ACRs) are underlined and in bold. The 10 cysteine residues conserved in all E-ATPases areindicated by a bold C with shading. Asparagine residues involved in potential...
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Báo cáo y học: "Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages" docx
... effects of im-mune-modulating cytokines on protein expression but focused on the effects on TLR mRNA expression. Pro-inflammatory cytokines may also control protein ex-pression of TLRs on the ... cytokines rather than TLR-ligand binding per se. The results of our study demonstrate that several pro-inflammatory cytokines contribute to the regula-tion of TLR expression. Of the cytokines ... Alterna-tively, they suggest that separate expression control of TLR5 by inflammatory cytokines may contribute to regulation of innate immunity in monocytes and neu-trophils. The effects of G-CSF and...
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Báo cáo y học: "Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes" pps
... IL-1β.Inhibition of iNOS by actinomycin and cycloheximide mayreflect, at least in part, inhibition of AP-1 complex synthesis,normally induced by BCP crystals.Conclusion In summary, this study ... andone is inducible (iNOS or NOS-2). Expression of iNOS hasbeen demonstrated in various cell types. Within the joint,chondrocytes may be the main cell source of NO, and iNOS expression is increased ... consistently described in chondrocytestreated with various inflammatory cytokines, including inter-feron-γ, TNF-α and IL-1β [43,62,63]. IL-1β seems to be thekey cytokine in the induction of...
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Báo cáo y học: "Early Differential signaling mechanisms regulate expression of CC chemokine receptor-2 during monocyte maturatio" ppsx
... tissues.PMA-treatment of monocytes induces selective downregulation of CCR2Based on the above results we decided to further examinethe regulation of CCR2 expression in monocyte matura-tion using the human monocyte ... granularity of the cells. In addi-tion, we demonstrated an up-regulation in expression of genes associated with monocyte differentiation, notablyCD11b, CD36 and CD68. Concomitantly, the expression of ... blood monocytes and monocyte-derived macrophages are keyregulatory components in many chronic inflammatory pathologies of the vasculature including theformation of atherosclerotic lesions. However,...
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Báo cáo y học: "Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ mice" pot
... chemokine and cytokinesynthesis, resulting in resolution of the inflammatoryinfiltrate. The effects of trauma on healing and tissueregeneration responses may depend upon the stimuli forits induction, ... cleanly cut or altered in configurationby the mice through scratching within a few days of injurywere excluded from the study. Typically, in non-injuredmice, the circular wounds healed in a ... dysfunction, delayed wound healing, multi-system organ failure and increased mortality.Methods: In this study, we examined the impact of thermal injury-induced systemic inflammation on the healing...
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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"
... effects on heart rate or blood pressure were observed in response to p-synephrine or p-synephrine in combination with naringin and hes-peridin (Table 2). p-Synephrine differs from ephedrine in ... participants were randomly assigned to one of the five dou-ble-blinded treatment conditions in which they con-sumed one ounce of V-8 juice containing the following ingredient variations: Group 1: Placebo ... reported in previous studies involving p-synephrine [17, 18]. The increase in RMR between Group 4, the combination of p-synephrine with 600 mg naringin and 100 mg hesperidin, and the placebo control...
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Báo cáo y học: "Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy"
... evaluating variations in pain intensity. Subjects are instructed to indicate the intensity of the pain by marking a 100-mm line anchored with terms describ-ing the extremes of pain intensity. ... proteins. Proinflammatory cy-tokines induce not only a local inflammation at the site of injury, but also systemic responses such as tachycardia, tachypnea, leukocytosis, and pyrexia (1). Increased ... Thoracotomy pain, Inflammatory response, Flurbiprofen Introduction Surgical trauma induces an inflammatory state characterized by the release of both proinflammatory and antiinflammatory proteins....
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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
... Beyer EC, Saffitz JE. Effects of angiotensin II on expression of gap junction channel protein connexin43 in neonatal rat ventricular myo-cytes. J Mol Cell Cardiol. 1998; 32: 800-7. 15. Polontchouk ... 4 and 5 independently showed the pro-tein expression of Cx43 and Cx40 in the iliac arteries of different groups. Figure 1. Hematoxylin/eosin staining of the iliac arteries in the normal ... 7(2):82-89 © Ivyspring International Publisher. All rights reserved Research Paper Effects of Losartan on expression of connexins at the early stage of athe-rosclerosis in rabbits Li-ming Ruan,...
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