Báo cáo y học: " Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma" pps
Báo cáo y học: " Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma" doc
... resistin and adip-sinareproteinmediatorssecreted by adipocytes andmacrophages within the adipose tissue [3]. Leptin and resistin are usually pro-inflammatory, while adiponectinhas mainly anti-inflammatory ... Journal of Inflammation 2011, 8:12http://www.journal-inflammation.com/content/8/1/12Page 2 of 7RESEARCH Open Access Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthmaSirpa ... theeffects of this adipokine on human THP-1 macrophages.Interestingly, resistin (0.1 - 2 μg/ml) increased production of proinflammatory cytokines IL-6 and TNF-a in THP-1cells in a concen tration-dependent...
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Báo cáo y học: " Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma" pps
... within the adipose tissue [3]. Leptin and resistin are usually pro-inflammatory, while adiponectinhas mainly anti-inflammatory properties [3]. Leptinlevels increase in obesity [4] and leptin ... favourable anti-inflammatory activ ity of fluticasone, we studied theeffects of this adipokine on human THP-1 macrophages.Interestingly, resistin (0.1 - 2 μg/ml) increased production of proinflammatory cytokines ... and healthy controls were found. The effects of resistin were also investigated in human macrophages in cell culture. Interestingly, resistin increased the production of proinflammatory factors...
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Báo cáo y học: "IL-6 predicts organ dysfunction and mortality in patients with multiple injuries" pps
... were prospectively included in this study.Patients with an injury severity score <16 points wereexcluded. In addition, patients with a history of steroiduse, anti-inflammatory treatment or ... CC Jr:Jack A. Barney Resident Research Award winner. Theinflammatory profile of interleukin-6, interleukin-8, and sol-uble intercellular adhesion molecule-1 in postinjury multipleorgan failure. ... 101:1644-1655.19. Talmor M, Hydo L, Barie PS: Relationship of systemic inflamma-tory response syndrome to organ dysfunction, length of stay,and mortality in critical surgical illness: effect of intensivecare...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... ±Birkprotease inhibitors [5], metallothioneins [6], prothymosina [7], a bacterial ®bronectin-binding protein [8], the brainprotein a-synuclein together with the related proteinsb-synuclein and c-synuclein ... aglobular protein c ontaining a similar number o f residues, asobserved in the caseins [3], synucleins [10], tau [14],prothymosin a [7] and the ®bronectin-binding protein [8],and also in typical chemically ... relies mainly on theevidence outlined above. In view of the c lose similarity of the ROA spectra of thecasein, synuclein and tau proteins shown in t his paper, wehave reproduced in F ig. 1...
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Báo cáo Y học: Mydj2 as a potent partner of hsc70 in mammalian cells doc
... existense of threedinstict domains, namely: the highly conserved J domainconsisting of approximately 70 amino acids a nd known tomediate the hsp70 binding; the glycin e/phenylalanine (G/F)rich ... but significant amounts of theprotein can be detected mainly in the cytoplasm. However alarger quantity of the protein seems to accumulate in thenucleus and especially in the nucleolus after ... chaperoningfunction [15] or the binding to membranes [16].Dj2 was found to cooperate with hsc70 in assisting thefolding of denatured proteins [10,17] and i n participating in the process of protein...
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Báo cáo Y học: Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation pdf
... somecircumstances. For instance, it increases the inactivation of a1-antiproteinase [51] and alcohol dehydrogenase [52]induced by hydroxyl radicals, and the oxidation of LDLmediated by peroxynitrite [53]. ... present 1 h after of Cu2+addition, whereas it was entirely consumed in the absence of ferricytochrome c. Finally, in order to specify the role of copper on the pro-oxidant effect of urate, experiments ... model system [39]. However, theexact mechanisms relating Cu2+redox change to theinitiation of LPO in LDL are not yet clearly established[40]. In the presence of pre-existing traces of hydroperox-ides...
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Báo cáo y học: "Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study" pps
... reduced in offspring with higherorder, indicating that the sibli ng effect may have it s ori-gin in utero [12], before an y hygiene effect in earlychildhood could affect the offspring. In addition, ... allergy or hay fever. Itis defined operationally by elevations in serum levels of immunoglobulin E (IgE) reactive with allergens or skintest reactivity to allergens [1]. Thus atopy is strictlylinked ... effect of IL13 polymor-phisms using the dominant model, i.e. the heterozygousgenotype was combined with the homozygous minorallele genotype in one category, while the homozygouscomm on allele...
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Báo cáo y học: "Disability and health-related quality of life in outpatients with generalised anxiety disorder treated in psychiatric clinics: is there still room for improvement" pdf
... the need for a continuing training of clini-cians in this type of condition, reviewing the criteria forreferral to specialists. Also, it should encourage training in prescribing the most suitable ... prevalence in thegeneral population of chronic pain in the Pain in Europesurvey was 19% [50], which is in contrast with the 46.7% of patients with GAD suffering pain for the last month in our study. ... 10:7http://www.annals-general-psychiatry.com/content/10/1/7Page 2 of 9body mass index (BMI, kg/m2), time of diagnosis anddelayed time to diagnosis (from the onset of symptomsto confirmation of GAD by diagnosis, in years)....
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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... spontaneously developperipheral polyarthritis that resembles human RA in manyclinical and pathological respects. This surprising findinginduced intense research into the pathophysiology of arthritis in ... glycolytic enzyme G6PIspecifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune disease.Interestingly, although GPI is ubiquitously expressed in thebody, ... against GPI appears toinitiate in the draining lymph nodes of peripheral joints in K/B×N mice [94]. The reasons for this early localizedimmune response are currently unclear but these findingssuggest...
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Báo cáo y học: " Aging, osteoarthritis and transforming growth factor-β signaling in cartilage" pps
... articular cartilage. The increased frequency of osteo-arthritis with aging indicates the complex etiology of this disease,which includes pathophysiology and joint stability includingbiomechanics. ... death in a variety of cell types including articular chondrocytes in thejoint. There are three isoforms of TGF-β, designated TGF-β1,TGF-β2, and TGF-β3, in mice and humans. TGF-β isoformshave ... responseincluding osteophyte formation and joint capsule thickening.The etiology of osteoarthritis remains unknown. At steadystate the homeostasis and response of articular cartilage isdetermined by the exquisite...
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