Báo cáo y học: " Innate immunity and monocyte-macrophage activation in atherosclerosis" potx

... heterogeneity of originating monocytes, and the inflammatory and lipidic stimuli available in the pla- que. It is known that signalling pathways related to innate immunity are strong determinants ... It relies on two arms: innate im munity and adaptive immunity. Innate immunity is activated immediately upon encounter with the pathogen and is executed pri- marily by myeloi...

Ngày tải lên: 11/08/2014, 03:20

... It relies on two arms: innate im munity and adaptive immunity. Innate immunity is activated immediately upon encounter with the pathogen and is executed pri- marily by myeloid cells with the participation ... of Ly6C + into Ly6C - monocytes. Other mechanisms proposed for this increase in Ly6C + monocytes during hypercholesterole- mia include in creased proliferation and reduc...

Ngày tải lên: 11/08/2014, 06:22

... Autophagy activation was evaluated by quantifying the fluorescence intensity of LysoTracker™ Red staining of blood mononuclear cells. Mitophagy was confirmed by measuring citrate synthase activity and ... and the elimination of dysfunctional mitochondria with mitophagy. Conclusions: These findings may support the role of oxidative stress and mitophagy in the pathophysiology of fib...

Ngày tải lên: 12/08/2014, 11:22

... TLR4, and TLR3, are expressed by FLSs, and their expression is increased in response to inflammatory stimuli [15,16]. FLSs exert a pro-inflammatory activity, essentially by synthesizing cytokines, ... 50 mM, in PBS, pH 7.4, for 20 min. Nonspecific binding was blocked by incubation in PBS containing 0.2% bovine serum albumin and 0.05% saponin for 30 min at 37°C. The cells were then...

Ngày tải lên: 12/08/2014, 14:22

... and other cytokines and acquiring increased T cell stimulatory capacity [68]. HIV stimu- lates pDC activation by a process that involves virion endocytosis following binding to CD4 and CCR5 and subsequent ... more sustained increase in IL-18 accompanied by elevations in multiple other pro-inflammatory cytokines/ chemokines, and a late-peaking increase in IL-10 [71]. The init...

Ngày tải lên: 13/08/2014, 01:20

... enzyme studied by this group is aromatic amine dehydrogenase. This enzyme is especially interesting because it is fairly nonspecific in the substrates it will bind and catalyze. In particular, in ... particular, in the series benzylamine, dopamine, and tryptamine, primary kinetic isotope effects range from a low of 4.8 in benzylamine to a high of 54.7 in tryptamine [58]. In a...

Ngày tải lên: 31/03/2014, 23:20

... Scale (GDS), and information was obtained on age, ethnicity, level of education, living arrangement, and psychiatric history. Two days post-admission, a clinical staff member caring for each ... hospitalized elderly adults will continue to in- crease in the coming decades. The National Health Inter- view Survey reports that in the United States in 1994, 8.3 million individuals ove...

Ngày tải lên: 08/08/2014, 20:23

... They play distinct physiological tasks from fine tuning membrane excitability in response to sensory input, modulating locomotion and emotional behavior to the induction of synaptic plasticity ... channels in aged mice may represent a mechanism that contributes to age-dependent decline in learning and memory and synaptic plasticity. In the hippocampus, SK3 was found predominantl...

Ngày tải lên: 08/08/2014, 21:20

... Bland RC, Danyluk L: Self-inflicted eye injuries and self-inflicted blindness. J Nerv Ment Dis 1979, 167:311-314. 8. Finkenbine R: Assaultive eye injury and enucleation. J Am Acad Psychiatry ... his home and finding no reason to con- tinue living. According to his description, the injury to his right eye was performed during one of these days in order to "change things" and...

Ngày tải lên: 08/08/2014, 21:20

... tolerance in the thymus. Competing interests None declared. References 1. Delon J, Stoll S, Germain RN: Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue. ... drive spontaneous autoimmunity to be defined. A model for T-cell activation can be envisaged in which each T cell integrates a range of proinflammatory, stimulatory and r...

Ngày tải lên: 09/08/2014, 01:23