Báo cáo y học: "Differential patterns of histone acetylation in inflammatory bowel diseases" pptx

... lysine histone acetylation is also stressed by Fraga and collea- gues who showed that global loss of acetylation lysine16 and trimethylation of lysine 20 of histone 4 is a com- mon hallmark of ... K16 acetylation. Finally, in biopsies of inflamed bowel and in Peyer’ s patches of Crohn’s disease patients, K8 and K12 were both s ignificantly acetylated. Acety lation...

Ngày tải lên: 11/08/2014, 06:22

... K16 acetylation. Finally, in biopsies of inflamed bowel and in Peyer’ s patches of Crohn’s disease patients, K8 and K12 were both s ignificantly acetylated. Acety lation on lysine r esi- dues in ... (NF-B), which is involved in pro -inflammatory cytokine gene transcription, is increased in the intestinal mucosa o f CD patients [31]. Modulation of histone acetylation...

Ngày tải lên: 11/08/2014, 03:20

... involves interconnected processes, including transcription by RNA polymerase II (Pol II), modification of histones, and processing of pre-mRNAs through capping, intron splicing, and polyadenylation. ... transcribed, binding and transcription by RNA polymerase II (Pol II), and processing of the pre- mRNAs, including the splicing of the non-coding introns [1,2]. Protein production is st...

Ngày tải lên: 09/08/2014, 23:20

... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is characterised by ... airway hyperreactivity in animal studies [12-14], they may have distinct roles in allergen-dependent airway obstruction [24]. Hence, NGF may play a role in the early airway response (EAR) i...

Ngày tải lên: 12/08/2014, 16:20

... Germany; 4 Department of Medicine, Section Pathophysiology, Johannes Gutenberg University of Mainz, Germany; 5 Department of Biochemistry, Christian Albrechts University of Kiel, Germany Ciliary neurotrophic ... 1–346) was linked via a single glycine residue to the N-terminus of human CNTF (amino acids 1–186). Recombinant Hyper-CNTF protein was expressed in COS-7 cells. Hyper-CNTF...

Ngày tải lên: 22/02/2014, 07:20

... by an increase in PAF biosynthesis via acetylation of 1-alkyl-2-lyso-GPC by acetyl transferase (Fig. 8, f) activity, competition for 1-alkyl-2-lyso-GPC intermediate by various transferases may ... synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-s...

Ngày tải lên: 22/02/2014, 07:20

... access [14]. In contrast to all Fe-hydrogenases including HydA of S. obliquus,the enzyme of C. reinhardtii has an interesting additional protein domain. A small insertion of 45 amino acids between ... synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA of C. reinhardtii, the first isolated gen...

Ngày tải lên: 08/03/2014, 22:20

... PMA- mediated acetylation of Ets1 are also unknown, but of future interest, as mutation of the Ets binding motif (m4) results in both a loss of protein binding and the TSA superinduction of Timp-1. Eleven ... (2003) Inhibi- tion of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodel- ing and increased histone acetylation. Oncogene 22...

Ngày tải lên: 16/03/2014, 18:20

... Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may amplify the enzyme function. In this scenario, deletion of mTEP1 in embryonic ... of dyskerin, although showing comparable inhibition of telomerase function in cells, exhibited a weaker inhibition of telomerase activity in the in vitro ass...

Ngày tải lên: 17/03/2014, 23:20

... studies investigating the recovery of trypsin- induced homogeneous GAG depletion in young bovine cartilage that the inherent ability of chondrocytes to replenish the matrix is relatively uniform ... recovery over the subsequent 3–4 weeks. Arner [1] also examined in vivo GAG synthe- sis and accumulation in rabbits following intra-articular injections of IL-1. Using dimethylmethylen...

Ngày tải lên: 09/08/2014, 01:21