Báo cáo y học: "Inhibition of allogeneic inflammatory responses by the Ribonucleotide Reductase Inhibitors, Didox and Trimidox" pot
Báo cáo y học: "Inhibition of allogeneic inflammatory responses by the Ribonucleotide Reductase Inhibitors, Didox and Trimidox" pot
... demonstrate here, the ability of these compounds to inhibit the secre- tion of the crucial cytokines, IL-2, IL-6, TNF-a and IFN-g thereby reducing the collateral damage caused by the d irect actions of these ... of the ribonucleotide reductase inhibitors, Didox and Trimidox, to act as inhibitors of inflammatory responses by both inhibiting the proli...
Ngày tải lên: 11/08/2014, 06:22
báo cáo hóa học: " Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1β production" pdf
... mediated by β 2-ARs and may involve cAMP The inhibition of nitrite accumulation by NE was mim- icked by the β-AR agonist isoproterenol used between 0.1 and 10 µM (Figure 4A), and by the cAMP ... catalyzed by intracellular esterases as well as extracellularly in the presence of serum, and that also releases the butyryl group from the 5'-position. The a...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... quite dramatically in the presence of 2-APB (by nearly eightfold). In addition, the rate constant for Ca 2+ dissociation in the presence of 2-APB is also substantially increased by nearly fourfold. As the ... characterize the mechanism of store-operated Ca 2+ entry, whereby Ca 2+ influx from the extracellular matrix is triggered by the emptying of Ca 2+ stores [7–10]...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo y học: " Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression" potx
... triplicate. Gene expression analysis by microarrays The microarray analysis of the effect of GliPR suppres- sion by siRNA was performed using the HG-U133 Plus 2.0 microarray of Affymetrix (Santa Clara, ... pathology. Conclusions: The up-regulation of GliPR by HIV-1 and the early significant inhibition of HIV-1 replication mediated by knockdown of GliPR reveal G...
Ngày tải lên: 12/08/2014, 23:23
Báo cáo y học: "Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex" potx
... extractability of the TFIIH subunits p62, Cdk7 and cyclin H were also examined. The salt extractability of Cdk7, cyclin H and p62 was unaffected by the addition of DRB and, consist- ent with their association ... concentrations of the P- TEFb inhibitors also decreased phosphorylation of the protein substrate. Phosphorylation of the largest subunit of DSIF by...
Ngày tải lên: 13/08/2014, 05:22
Báo cáo y học: "Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis" pptx
... the haplotypes of the markers of the two genes were analyzed separately. Haplotype analysis of IL-13 predicted four haplotypes, all of which had a frequency above 1%. Compared with the most common ... proliferation and differen- tiation of B cells and induces IgE and IgM production. The role played by these genes in RA susceptibility and sever- ity is not clearly...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: " Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation" ppsx
... fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals. It is not yet clear whether the distribution of this virus is primarily limited to the USA or whether it ... neutralis- ing activity. Only one of these was from a CFS patient [9]. In the other study, neither XMRV nor murine leu- kemia virus sequences were detecte d. The authors came to th...
Ngày tải lên: 12/08/2014, 23:23
Báo cáo y học: " Lack of adaptation to human tetherin in HIV-1 Group O and P" pot
... activities in group O and P Nef proteins ThefactthattheH(+5)tetherinwasantagonizedby pCMO2.5 implicated Nef as the anti-tetherin factor in this virus. We therefore examined the activity of the pCMO2.5 ... measure the effect of tetherin, and its antagonists, on the effi- ciency of virus release. Analysis of VLP release in the presence of the various tetherins reveal...
Ngày tải lên: 13/08/2014, 01:21
Báo cáo y học: "Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor" pot
... localiza- tion of NFκB and the production of pro -inflammatory mediators [22]. Based on an array of over 200 genes acti- vated by RP3, two of the most highly induced are the pro- inflammatory chemokines ... Pierotti MA: Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene. Proceedings of the National Academy of Sciences o...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
... wide. The mountains of the Appennine range divide Parma Province from Tuscany and from Ligury, and Po river flows through its territory. The territory of Parma Province presents two types of ... the food valley”. The characteristics of the environment, the presence of woods and the habit of consuming sausages and raw meat make Parma Province an endemic...
Ngày tải lên: 03/11/2012, 11:11