Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... com-
plexes and thereafter their roles in disease.
In summary cigarette smoke exposure reduced HDAC-
2 activity and the expression of mSin3a and Mi-2α in the
lungs of smoke exposed mice. This may contribute ... either the composi-
tion or the stepwise construction and targeting of the
mSin3a and Mi-2 co-repressor complexes or their role in
disease....
... the original work is properly cited.
Research
Cigarette Smoke Exposure Alters mSin3a and
Mi-2α/β Expression; implications in the control of
pro-inflammatory gene transcription and
glucocorticoid ... hormone
receptors including the glucocorticoid receptor α (GRα)
[10-15]. HDACs function by deacetylating of key compo-
nents of the transcriptional ma...
... acquisition and analysis of
data. TM has been involved in drafting the manuscript
and revising it critically. GB participated in the critical
reading of the manuscript. KT has been involved in the
conception ... immune
response [16]. The involvement of DC in the observed
pathology is suggested by the significant increase of DC in
both BALF and lung tissue...
... amylose continues to
accumulate at the final stage of starch synthesis in the
absence of concomitant amylopectin synthesis (reviewed in
[41]).
In vitro
synthesis of amylose
Because in Chlamydomonas ... and we can only
state that the latter certainly does not exceed the rate of
amylopectin synthesis. The increase in crystallinity wit-
nessed during these first 12 h...
... Side-chain packing in the regions responsible for the stability of HT c-552, and the corresponding regions in the wild-type PA c-551 and its
quintuple mutant. The mutated residues in the quintuple ... noncovalent
interactions. We further found that the increase in the
stability of the quintuple mutant is almost the same as
the sum of the three individ...
... Consideration of the potential role of protein disorder
may give novel insights into the possible role of molecular
mimicry in the pathogenesis of autoimmunity. The recognition of
extreme autoantigen ... as link-
ers connecting domains of topoisomerase I that interact with
opposite sides of the DNA; they may be unstructured in the
apoprotein and become ordered...
... with induction of T-cell tolerance
and immune inhibition in the induction of oral tolerance in the
murine CIA model. We examined the change in the expression
of IDO in CD11c
+
DCs of Peyer's ... activity in the small
intestine and the epididymis of mice. Arch Biochem Biophys
1980, 203:343-351.
33. Malina HZ, Martin XD: Indoleamine 2,3-dioxygenase: ant...
... neck
extending from the upper neck to the supraclavicular
fossa. The mass was soft, compressible, non-tender, and
fixed. There were no associated changes in the overlying
skin. The remainder of the physical ... large cystic neck mass and was confused with a cystic hygroma. Her mother reported
a progressive increase in the size of this swelling and mild respiratory...
... more inflammatory
mediators and help modulate the inflammatory response?
Unfortunately, there is no direct evidence that increasing
the Q
UF
increases cytokine removal with CVVH. Indeed, the
available ... Reiter, Rinaldo Bellomo and Claudio Ronco
The sepsis syndrome is associated with an overwhelming
systemic overflow of pro-inflammatory and anti-inflammatory
mediators, lead...
... am Main and was internally funded. The study is independent of
any pharmaceutical interest.
Author details
1
Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy,
University Hospital ... [8,21-23] and for the detec-
tion of cytokines in the BAL in the context of
ventilator-associated lung injury [24]. No data exist,
however, on whether the technique...