... function down-stream of cPLA2-a and convert arachidonic acid intoprostaglandin H2[8,9]. To date, two distinct COX iso-forms, COX-1 and COX-2, have been identified and characterized, and an ... (1996)‘Cytosolic’ phospholipase A2 is in the nucleus of sub-confluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to thenuclear envelope and cell ... found to be coupled to both COX-1 and COX-2 to produceprostaglandin E2[51]. The physical colocalization of COX and cPLA2-a in these systems, however, has notbeen studied, and this is one of...