Báo cáo y học: "Twelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005)" pdf
Báo cáo y học: "Twelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005)" pdf
... survey was returned bymail.Analysis To examine changes in guideline development, dissemi-nation, and evaluation over time, the year of release of theguidelines was arbitrarily dichotomized into ... AccessResearch articleTwelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005)Jennifer Kryworuchko1, Dawn Stacey1, Nan Bai2 and Ian D Graham*1,3Address: ... ongoing monitoring of guideline quality is required. Guidelinesproduced more recently in Canada are less likely to be based on a review of the evidence and onlyabout half discuss levels of evidence...
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báo cáo khoa học: " Twelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005)" ppsx
... survey was returned bymail.Analysis To examine changes in guideline development, dissemi-nation, and evaluation over time, the year of release of theguidelines was arbitrarily dichotomized into ... substantiallyover the 12 year period from 5% to 24% of guidelines.Data on the positive health outcomes of guidelines maybe useful for encouraging others to incorporate guidelinesinto their healthcare ... glimpse in the guideline industry in Canada and how it is evolving. We are unaware of any other nationallongitudinal data revealing trends over time in the prac-tices of major guideline developers....
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Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"
... University of Calgary, Calgary, AB T2N 2T9, Canada 3Department of Medicine, University of Calgary, Calgary, AB T2N 2T9, Canada 4Alberta Kidney Disease Network, Calgary, AB T2N 2T9, Canada 5Calgary ... mediannumber of days of hyponatraemia (IQR = one to three days) and hypernatraemia (IQR = one to five days) was two.Multivariable analysis of patient characteristicsThe incidence of ICU-acquired hyponatraemia ... data, interpreted data and revised themanuscript. HTS and FK had full access to all the study data and assume responsibility for the integrity of the data and theaccuracy of the analysis.References1....
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Báo cáo Y học: The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme pdf
... Determination of 11b-hydroxylase capacity of CYP11B2 mutants in relation to the wild-type enzyme, whenincubated with 11-deoxycortisol. The 11b-hydroxylation of 11-deoxycortisol catalysed by the ... part of humanCYP11B2.Keywords: c ytochrome P450; 11 b-hydroxylase, aldosteronesynthase; N-terminal protein region; engineering substratespecificity.Cytochromes P 450 a re key enzymes in the ... contribution of helices A, B, B¢,FandGtothehigh specificity of other cytochromes P450 [47].Our finding of an exclusive increase in the 1 1b-hydroxy-lation capacity of CYP11B2 by the replacement D147Eindicates...
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Báo cáo y học: "Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia" potx
... a large fam-ily of proteolytic enzymes containing a metal in theirorganic structure playing key roles in degradation of pro-teins in extracellular matrix and in tissue remodelingthrough complicated ... significance.MethodsA total of 80 consecutive patients managed in a singleinstitution were prospectively included in the study over aperiod of two years. Patients were classified according to the underlying ... non-steroid anti-inflammatory medication, or a history of chronic pulmo-nary disease or malignancy of any type. All these clinical conditions have been associated with elevated levels of serum MMPs...
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Báo cáo y học: "Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung" potx
... Finland, 3 Clinical Research Center, and Institute of Clinical Medicine, Department of Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland and 4Department of Pathology ... 2Institute of Clinical Medicine, Department of Internal Medicine / Respiratory Research Unit, Centre of Excellence in Research and Clinical Research Center, University of Oulu and Oulu University Hospital, ... Duodecim of Oulu and the Finnish Cancer Society. The funding body had no role in study design; in the collection, analysis and inter-pretation of data; in the writing of the manuscript; and in the...
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Báo cáo y học: "Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes" pdf
... Olincy A, Martin L: Diminished suppression of the P50 auditoryevoked potential in bipolar disorder subjects with a history of psychosis. Am J Psychiatry 2005, 162:43-49.13. Weiland S, Bertrand ... reported findings sim-ilar to those of the study conducted by Wang and colleagues[7], in which 46 SMC(15)s were analyzed using a combination of fluorescent in situ hybridization and microsatellite ... map-ping; 32 of the 46 exhibited two distinct breakpoints close to BP4 and BP5, and 14 out of 46 had two very closely locatedbreakpoints near to BP3. Two smaller studies using eitherCGH [36] and...
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Báo cáo y học: " Ten years of Genome Biolog" doc
... the support of our readers and advisory board has helped shape Genome Biology into the journal that it is today. We are committed to listening to your feedback, continually reassessing our thresholds ... thresholds and criteria for publication, and developing the journal according to your needs, and we look forward to your continued support and feedback.We are marking Genome Biology’s tenth birthday ... advisory board and a continued editorial presence at international conferences will help us to reach out to our readers, to continue to attract the very best genomics articles, and to stay ahead...
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Báo cáo y học: "Iatrogenic insertion of impression mould into middle ear and mastoid and its retrieval after 9 years: a case report" pdf
... process of makingthe mould for a hearing aid led to the perforation of thetympanic membrane and pouring of mould material intothe middle ear, necessitating surgical intervention. Duringinitial ... removal of material byemploying mastoidectomy with facial recess approach to the middle ear. In this instance the hearing mechanism of the ear was compromised leading to further hearingimpairment. ... from mastoidcavity.BackgroundA 2 year old boy was brought to us by his parents fordelayed speech development. There was no history of con-sanguineous marriage of parents. Pregnancy as describedby...
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Báo cáo y học: "Systematic review of clinical trials of cervical manipulation: control group procedures and pain outcomes" pptx
... adults.Beyond the issues of indistinguishability, equivalence and clinical effect, a very serious issue is the lack of deter mination of the level of blinding in the vast major-ity of these ... blinding. The effect of unmasking of controlsubjects makes the interpretation of the existing clinical trials challenging. At the very least, future clinical trialreports should include an indication ... changes in pain, ten-derness or other singular physical findings. Despite theissues raised above on lack of equivalence and theeffects of unmasking, this type of procedure may besatisfactory for...
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