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Báo cáo y học: "The role of conversation in health care interventions: enabling sensemaking and learning" pptx

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Báo cáo y học: "The role of conversation in health care interventions: enabling sensemaking and learning" pptx

... ways that improve sensemaking and learning, or they may be conversing in ways that inhibit sensemaking and learning. The success of the intervention is affected by conversations that aretaking ... failure of overlooking the role of conversation in intervention success, and to develop a theoretical argument for the importance of paying attention to the role of conversation in health care interventions.Discussion: ... emerged and alsoprovided input into the role of conversation in the studiesthey conducted. PN and WM contributed to the design of the manuscript and in analyzing the role of conversation in practice...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

... indicatingthat, in the absence of coenzyme M, zinc is probablycoordinated by a single sulfur ligand and three oxygen ornitrogen ligands. In the presence of coenzyme M, one(N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In theHis237 fi Ala and Cys239 fi Ala mutants, coenzyme Malso seemed to bind efficiently by ligation to zinc indicatingthat some aspects of the zinc ligand ... &Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. J. Am. Chem Soc. 120,8410–8416.15....
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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

... delivery. The frequency of developingatopic dermatitis in the offspring was significantlyreduced by 2, 4, and 7 years [26-28], by 50%, 44%, and 36% respectively.Similar studies have yielded ... in Estonian and Swedish infants. Clin Exp Allergy 2005, 35(2):153-9.12. Bjorksten B, et al.: Allergy development and the intestinalmicroflora during the first year of life. J Allergy Clin Immunol2005, ... allergy.factors influencing development of the microbiota. Ann Med1999, 31(4):288-92.15. Kalliomaki M, Isolauri E: Role of intestinal flora in the develop-ment of allergy. Curr Opin Allergy Clin...
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Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

... Anatomy, Physiology and Clinical Medicine in 1878. (c)Title of the manuscript, meaning “The finer changes of joint cartilage in fungous synovitis and caries of the joint-ends”. Fungous synovitis ... consequently lead to increasing inter-est in the role of osteoclasts in local bone erosion that isdriven by the hypothesis that synovial pannus makes useReviewThe role of osteoprotegerin in arthritisGeorg ... Collagen-induced arthritisSpecies Rat Mouse RatDose 1 mg/kg/day 6.4 mg/kg/day 3 mg/kg/dayStart Onset of symptoms Onset of symptoms Onset of symptomsDuration 7 days 35 days 5 daysEffect on inflammation...
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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc

... family [32]. Physiological levels of leptin can modulatethe response to an inflammatory challenge by alteringproduction of proinflammatory and anti-inflammatory cytokines and may also affect cytokine ... & Therapy Vol 8 No 5 Bernotiene et al.inflammatory and anti-inflammatory factors, including adipo-cytokines, such as leptin, adiponectin and resistin, as well ascytokines and chemokines. Altered ... circulating T lymphocytes when theyare costimulated by phytohemagglutinin or concanavalin A and modulates CD4(+) T lymphocyte activation toward a Th1phenotype by stimulating the synthesis of IL-2 and...
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction.To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the totalunitary free energy of binding of cystatin A to ... cathepsin B,demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may bedirectly involved in the interaction with cathepsin B byproviding hydrophobic...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of theenzyme for PAA and derivatives thereof, while maintainingthe hydrophobicity of the binding site.To ... (kcat/Km)forp-hydroxyphenylgly-cine methyl ester and phenylglycine methyl ester that weresimilar to the wild-type values, whereas the specificity con-stants for p-hydroxyphenylglycine amide and phenylglycineamide ... methyl ester or the amide asacyl donor.It appeared that 6-APA and 7-ADCA were able toefficiently deacylate the phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF24A, as indicated by, respectively,...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) and the carboxylate of the a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 and ... ternary com-plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to primesubstrate oxidation. In the case of DAOCS it has been previously shown...
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... activity of a glucocorticoid-regulated inflammatorycyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-matory therapy. ... their role in bone metabolism and repairremains unclear.Review of the evidenceTo determine the role of COX-2 in bone repair, investiga-tors have studied fracture healing in animal models of COX-2 ... critical role of COX-2 in mesenchymal cell differentiation during skeletal repair.Using COX-1-null and COX-2-null mice, they demon-strated the essential role of COX-2 in both endochondral and intramembranous...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses theinterplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... intracellulardomain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated ... tenosynovium and from jointsynovium, and we found that oxygen in invasive teno-synovium was 43% lower than in matched joint synovium, and 28% lower than in matched encapsulating teno-synovium....
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