Bone Regeneration and Repair - part 2 pdf
... Adenovirus-mediated direct gene therapy with bone morphogenetic protein -2 produces bone. Bone 24 (6), 541–547. 20 6. Watanabe, S., et al. (20 00) Adeno-associated virus mediates long-term gene transfer and ... following p. 21 2.) This is trial version www.adultpdf.com Cell Therapy for Bone Regeneration 67 67 From: Bone Regeneration and Repair: Biology and Clinical App...
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... by primitive mesenchymal proteins (BMP -2 , and IGF-II expression (69) and osteoprogenitor cells, fibroblasts, BMP-4, BMP-7) –BMP -2 increases TGF-β and IL-6 and proliferating chondrocytes (66–68) expression ... lineage (re- viewed in ref. 1 02) . ILs (1,6, and 11), PTH, PTHrP, TNF, prostaglandins, annexin-II, TGF-β, M-CSF, and RANK ligand stimulate osteoclast formation (13,97,98...
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... molecules ICAM-1 and -2 , VCAM-1, L-selectin, LFA-3, ALCAM ICAM-3, cadherin-5, E-selectin, P-selectin, PECAM-1 Miscellaneous antigens Transferrin receptor, CD9, Thy-1, SH -2 , SH-3, SH-4, SB -2 0 , SB -2 1 CD4, ... absent Integrins α1, 2, α3, α5, α6, αv, β1, β3, β4 2, α4, αL Growth factor and cytokine receptors bFGFR, PDGFR, IL-1R, IL-3R, IL-4R, IL-6R, IL-7R, IFN-γR, EGFR-3, IL-2R TNFIR...
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Bone Regeneration and Repair - part 4 ppt
... United States and Europe. Kirker-Head and coworkers evaluated the long-term healing of bone using rhBMP -2 in adult sheep ( 72) . By 12 mo all the defects were structur- ally intact and were rigidly ... Scand. 62, 24 4 24 7. 12. Dubreuil, P., Abribat, T., Broxup, B., and Brazeau, P. (1996) Long-term growth hormone-releasing factor adminis- tration on growth hormone, insulin-like...
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Bone Regeneration and Repair - part 5 ppt
... elegans. All TGF-βs are disulfide-linked dimers comprising 12 18 kDa subunits (55). Most are homodimers (TGF-βl, TGF- 2, and TGF-β3), but some are heterodimers (TGF-β1 .2 and TGF- 2. 3) (56). TGF-βs are ... stimu- lates bone resorption and inhibits formation in vitro. Proc. Natl. Acad. Sci. USA 83(7), 22 28 22 32. 61a. Iwata, H., Sakano, S., Itoh, T., and Bauer, T. W. (20 02) Dem...
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Bone Regeneration and Repair - part 6 pot
... model (9,11,13,14,19 ,21 ,22 ,45, 124 ), others have mod- ified it for lengthening of the femur ( 122 ), radius and ulna (54), or mandible (50,66), and for bone trans- portation ( 32, 55). Many species ... demonstrated earlier bone formation and re- modeling, with an overall bone healing index of 22 d/cm compared to 26 .5 d/cm in the diaphyseal sites. The rate of bone formatio...
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Bone Regeneration and Repair - part 7 pot
... (LMP-1). Spine 23 , 24 86 24 92. 91. Viggeswarapu, M., Boden, S. D., Liu, Y., et al. (20 01) Adenoviral delivery of LIM mineralization protein-1 induces new -bone formation in vitro and in vivo. J. Bone ... materials—rhbmp -2 and autograft. J. Spinal Disord. 9, 125 – 128 . 78. Boden, S. D., Martin, G. J., Horton, W. C., Truss, T. L., and Sandhu, H. S. (1998) Laparoscopic anterior...
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Bone Regeneration and Repair - part 8 pot
... 3.8 PHALANX (FINGER) 21 /24 87.5% 3.4 PHALANX (TOE) 22 /29 75.9% 3.7 RADIUS 81/96 84.4% 5.0 RADIUS/ULNA 14/17 82. 4% 5.3 TARSAL 51/77 66 .2% 4.3 TIBIA 28 5/3 72 76.6% 6 .2 TIBIA/FIBULA 122 /154 79 .2% 5.8 ULNA ... biological tissues. Nature 21 2, 26 7 26 8. 5. Williams, W. S. and Perletz, L. (1971) P-n junctions and the piezoelectric response of bone. Nat. New. Biol. 23 3, 58–59....
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Bone Regeneration and Repair - part 9 docx
... phenotypes and angiogen- esis ( 120 ), suggesting a strong involvement in bone formation, fracture repair, and bone regeneration. Moreover, FGF -2 has a potent influence on bone formation ( 121 – 124 ), especially ... members; FGF-1 (acidic FGF -2 may be a candidate agent for bone regenera- tion) is angiogenic and osteogenic (118,119). The biological activities of FGF -2 i...
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Bone Regeneration and Repair - part 10 potx
... applications arthrodiastasis, 21 6 bone transportation, 21 2 21 4 deformity correction, 21 1, 21 2 foot reconstruction, 21 5, 21 6 fracture repair, 21 4, 21 5 limb lengthening, 20 7 20 9 nonunions, 21 2 overview, 20 6, 20 7 complications ... 341 granulocyte–macrophage colony- stimulating factor, 28 , 29 , 32 insulin-like growth factors, 26 , 27 , 30 interleukin-1, 28 , 32...
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