Bone Regeneration and Repair - part 1 ppt
Bone Regeneration and Repair - part 1 ppt
... lineage (re-
viewed in ref. 10 2). ILs (1, 6, and 11 ), PTH, PTHrP, TNF, prostaglandins, annexin-II, TGF-β, M-CSF,
and RANK ligand stimulate osteoclast formation (13 ,97,98). M-CSF and RANK ligand are ... M., Ros, M., and Hurle, J. (19 97) Role of BMP-2 and OP -1 (BMP-7) in
programmed cell death and skeletogenesis during chick limb development. Development 12 4, 11 09 11 17....
Bone Regeneration and Repair - part 4 ppt
... extracellular matrix (11 4). Indeed, bone is the largest repository of TGF-β in the
body (11 5). During fracture healing, both TGF-β mRNA and protein are present in the fracture callus
(10 5 ,11 6 ,11 7). Expression ... indicate that TGF-β inhibits osteoclast formation and function (10 9), and TGF-β has been
reported to both stimulate (11 0 ,11 1) and to inhibit (11 2) type II coll...
Bone Regeneration and Repair - part 5 ppt
... elegans.
All TGF-βs are disulfide-linked dimers comprising 12 18 kDa subunits (55). Most are homodimers
(TGF-βl, TGF-β2, and TGF-β3), but some are heterodimers (TGF- 1. 2 and TGF-β2.3) (56). TGF-βs
are ... of OP -1 bone morphogenetic pro-
tein (BMP-7) in a human fibular defect. J. Bone Joint Surg. 81( 4), 710 – 718 .
48. Gerhart, T., Kirker-Head, C., Kriz, M., et al. (19 91) Healing...
Bone Regeneration and Repair - part 2 pdf
... pro-
liferation of T-lymphocytes, and stimulates cytokine secretion (10 2 ,11 1 11 4). This cytokine activity
has been associated with increased fibroblast migration and collagen synthesis (11 5 11 7), ... (19 92) Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinol-
ogy 13 1(3), 10 75 10 80.
61. Beck, F., et al. (19 87) Histochemical localization...
Bone Regeneration and Repair - part 3 doc
... PDGFR, IL-1R, IL-3R, IL-4R, IL-6R, IL-7R, IFN-γR, EGFR-3, IL-2R
TNFIR and TNFIIR, TGFβIR and TGFβIIR
Cell adhesion molecules
ICAM -1 and -2 , VCAM -1 , L-selectin, LFA-3, ALCAM ICAM-3, cadherin-5, E-selectin,
P-selectin, ... A. I. (19 90) Osteochondral differentiation and the emer-
gence of osteogenic cell-specific markers by bone marrow cells in diffusion chambers. Bone Miner...
Bone Regeneration and Repair - part 6 pot
... isolated chon-
drocytes from rabbit ear and epiphyseal plate. Endocrinology 11 2, 11 27 11 29.
16 2. Canalis, E. (19 97) Insulin-like growth factors and osteoporosis. Bone 21, 215 – 216 .
16 3. Schalch, ... Endocrinology 11 1, 11 8 12 4.
15 2. Andrew, J. G., Hoyland, J., Freemont, A., et al. (19 95) Platelet-derived growth factor expression in normally healing
human fractures. B...
Bone Regeneration and Repair - part 7 pot
... large extent independent of the allograft
surgery (1 3,5,6 ,17 , 21, 23,26,76 ,10 5 ,11 0 ,11 1 ,11 5 ,11 6). More characteristic and specific for the allo-
geneic transplant procedure itself, however, are ... in part due to an inflam-
matory and immunological host-to-graft response (10 ,11 ,14 ,15 ,18 ,19 ).
Histological Analysis of Implanted Bone Grafts
Several series have documente...
Bone Regeneration and Repair - part 8 pot
... (mo)
ANKLE 11 0 /14 5 75.9% 4.7
CARPAL NAVICULAR 15 4/ 218 70.6% 3.9
CARPAL/
METACARPAL 35/39 89.7% 5.3
CLAVICLE 79 /11 4 69.3% 5 .1
FEMUR 16 0/250 64.0% 6.4
FIBULA 58/68 85.3% 4.3
HUMERUS 10 3 /18 0 57.2% ... Orthop. 243, 12 6 13 7.
53. Schreurs, B., Slooff, T., Buma, P., et al. (19 98) Acetabular reconstruction with impacted morcellized cancellous bone
graft and cement. A 1 0-...
Bone Regeneration and Repair - part 9 docx
... (10 ,28,94,98 ,10 1,
11 9 ,12 7 13 0), delayed and nonunion (4,89 ,10 1 ,12 7 ,13 1), thrombosis (15 ,12 1 ,12 4), infection (49 ,12 7,
13 2), and those related to the fibula donor site (4,75,78,93 ,11 1 ,11 7 ,11 8 ,13 3 13 6). ... calcium-phosphate, rhBMP-2 appears to be an effective spine fusion
option (11 1 ,11 3 ,11 4). However, rhBMP-2 has had limited success for maxillary sinus l...
Bone Regeneration and Repair - part 10 potx
... therapy
applications, 16 5
ex vivo gene transfer, 16 1, 16 2
genes for bone healing promotion,
16 3 16 5
in vivo gene delivery, 16 3
prospects for fracture repair, 36, 37,
16 5, 16 6
rationale for bone healing, 15 7, 15 8
vectors, ... 350
osteoconduction, 13 7, 13 8, 14 0
I
IGFs, see Insulin-like growth factors
IL -1 , see Interleukin -1
IL-6, see Interleukin-6
Ilizarov tec...