Báo cáo y học: "Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation" ppt

... status of obese/diabetic patients. Therefore, we studied the effect of SR141716A on human adipocyte inflammatory profile and differentiation. Methods: Adipocytes were obtained from liposuction. ... on the surface of adipocytes, and in particular in fully differentiated mature adipocytes [23]. Some of the beneficial clinical effects of the CB1 antagonist...

Ngày tải lên: 11/08/2014, 03:20

... interaction of the backbone atoms and the side- chain Cb atom [35,37–40]. This may be the reason why the mutation at Gly10 destabilizes the protein. Thus, Gly10 contributes to the stabilization of ... represents 6-carboxyfluorescein. All oligonucleotides were synthesized by Hokkaido System Science. Hydrolysis of the substrate at 30 °C for 15 min and separation of the...

Ngày tải lên: 17/03/2014, 17:20

... aspirin and all cytokine inhibitors 10 to 14 days prior to surgery. Histology of synovial biopsies and levels of cytokines Haematoxylin and eosin histology was performed on 26 of the OA and 9 of the ... due to their ability to modulate the endocannabinoid system [20,21]. The endocannabinoids and PEA are synthesised on demand, and AEA, PEA, and OEA are metabol...

Ngày tải lên: 09/08/2014, 10:23

... measurement s of 40 IU in the morning and 15 IU in the e vening, and glycosylated hemoglobin levels >8%, which required adjustments of his insulin dose and addition of on- demand fast-acting ... at the mainte- nance dose, all u lcers had improved and marked granu- lation tissue was apparent on the heel ulcer (Figure 1E) and the ulcer on the flexure of t...

Ngày tải lên: 11/08/2014, 00:23

... University of Bonn, Germany, 5 Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Germany and 6 Department of Psychiatry and Psychotherapy, Philipps-University Marburg, ... G72 and the glutamate hypofunction hypothesis of schizophrenia [41]. Another study however failed to confirm the interaction between G72 and DAAO [42]. Rather, LG72,...

Ngày tải lên: 11/08/2014, 17:20

... further aggravation of the systemic haemodynamic dysfunction associated with portal hyperten- sion, also called the hyperdynamic state. The hyperdynamic state is characterized by a reduced systemic ... studies have emphasized the relation between the degree of arterial hypotension in cirrhosis and the severity of portal hypertension, hepatic dysfunction, signs of decompe...

Ngày tải lên: 13/08/2014, 01:20

... to the conception and design of the study, revised the manu- script critically, and gave final approval for publication. SEW contributed to the conception and design of the study, conducted and ... them to go on the roads and try to get [to clinic]. The risks to personal safety were seen to vary based on the fam- ilies' tribal affiliation, their location...

Ngày tải lên: 25/10/2012, 10:31

... detection. Nucl A Res 1991;21: 3623-3629. 11. Chen S, Tsybouleva N, Ballantyne CM, Gotto AM, Marian AJ. Effects of PPARα, γ and δ haplotypes on plasma levels of lipids and progression of coronary ... obtained by Chen et al. [11], who studied 4 PPARδ haplotypes and found that effects on plasma lipids and coronary lesions were primarily due to the influence of the +...

Ngày tải lên: 31/10/2012, 17:03

... a deviation from the bounds predicted by the excluded volume theory and a dispersion for the values of the cri- tical exponent (t) [6,7]. It was demonstrated that the conductivity of CNT/polymer ... given concentration and shifts the percolation threshold to higher concentrations (Figure 4). This behavior is mainly due to the reduction of the surfac e conductivity o...

Ngày tải lên: 21/06/2014, 04:20

... total and myosin heavy chain type-specific plantaris muscle fiber areas. In both tissues, the levels of cystine (Cyss), the oxidized form of the anti-oxidant cysteine (Cys), and Cyss:Cys ratios ... performed on plantaris muscles to detect levels of the thiol pairs GSH and GSSG, and Cys and Cyss. HIV-1-related protein expression increased the levels of GSSG (B)...

Ngày tải lên: 10/08/2014, 05:21