Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
... pretreatment results in an inhibition of inflammatory signaling in cells with CF defects. Production of IL-8 and other pro-inflammatory cytokines is also governed by mechanisms regulating in their mRNA ... extracellular-regulated protein kinase (ERK) cascades are active by phosphorylation through dual specificity MAPK kinases (MKK) and may all contribute to IL-8 expression. We found no difference in baseline ERK- phosphorylation ... parthenolide inhibits inflammation in CF both in vivo and in vitro by inhibiting IKK/NFκB pathway. Parthenolide has been considered by some to be a specific inhibitor of the NFκB pathway [34-39]. During...
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Báo cáo y học: "Airflow limitation or static hyperinflation: which is more closely related to dyspnea with activities of daily living in patients with COPD?" ppt
... reported that indices related to hyperinflation, such as the inspiratory capacity (IC), are more closely related to exercise tolerance and dyspnea than the forced expiratory volume in 1 second ... static lung hyperinflation estimated by the inspiratory capacity to- total lung capacity (IC/TLC) ratio is a predictor of all-cause and respiratory mortality in patients with COPD, independent ... Kyoto, Japan; 2. Kyoto-Katsura Hospital, Kyoto, Japan; and 3. Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. KN:...
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Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation potx
... Epac,may instead activate a tyrosine phosphatase which results in the observed decrease in both basal and CSF-1-induced tyrosine phosphorylation. In contrast to the data for EGFR-dependent tyro-sine ... monocyte DNA synthesis by colony-stimulatingfactors, cytokines, and cyclic adenosine monophosphate.Blood 79, 1972–1981.9 Vairo G, Argyriou S, Bordun AM, Whitty G & Hamil-ton JA (1990) Inhibition ... surprisingly, thatinstead of there being more tyrosine phosphorylationthere was in fact a reduction in the degree of tyrosinephosphorylation of CSF-1R and that was found gener-ally in whole...
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Báo cáo y học: "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood" ppt
... bonemarrow cavity in chronic inflammatory arthritis.IntroductionTNF is a clinically validated etiological factor in inflammatory-erosive arthritis and is known to synergize with RANKL and macrophage ... in inflammatoryosteolysis. Arthritis Res Ther 2006, 8:201.2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors:cytokine-stimulated immunomodulators of inflammatory bonedisease. Curr Opin ... colony-stimulating factor (M-CSF) for 3 days to generate osteoclast precursors (OCPs). Cells were stained with allophy-cocyanin-labeled anti-CD11b and Phycoerythrin-labeled anti-Gr-1 antibodies and...
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Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... F, Ficheux H, Pujol JP: Rhein inhibits interleukin-1 beta-induced activation of MEK /ERK pathway and DNA binding of NF-kappa B and AP-1 in chondro-cytes cultured in hypoxia: a potential mechanism ... growthfactors, cytokines, proteases, and inflammatory mediators. Thelevels of alkaline phosphatase, osteocalcin, type I collagen,interleukin (IL)-6, transforming growth factor-beta, prostaglan-din ... Canada)containing hydroxide peroxide. Slides were counterstainedwith hematoxylin/eosin.The staining specificity of the antibody used was determinedusing three controls according to the same...
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Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot
... signals in macrophages [7]. The two pro-inflammatory enzymes, induciblenitricoxidesynthase(iNOS) and cyclooxygenase-2 (COX-2), which can beinduced by LPS or cytokines, are found to work in concert in ... the production ofinflammatory cytokines, chemokines, and proinflamma-tory enzymes (e.g. iNOS and COX-2) [38-40]. The pro-moter of the iNOS and COX-2 genes are known to contain two transcriptional ... modulation by curcumin and pyrrolidine dithiocarbamate ofthe UVB-induced cytokine expression by keratinocytes. Cytokine 2002,18:168-177.42. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH,...
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Báo cáo y học: " Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis" doc
... expres-sion in joints affected by AIA on Day 1. Abundant stain-ing was detected in the synovial lining layer, joint exudate and focal areas of synovial infiltration; it was comparable in WT and IFN-γ-/- ... IL-1β induced MMP secretion by RA FLS In RA cartilage damage is predominantly mediated by theMMPs; most notably MMP-1, -13 and -3 [19]. Their syn-thesis is driven by pro-inflammatory cytokines, ... Plasma and synovial cytokine expression was assessed together with histological measures of arthritis severity dur-ing early arthritis (one day after i.a. mBSA injection). (A) Plasma cy-tokine expression...
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Báo cáo y học: "Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway" pot
... play in allergic, asthmatic, and inflammatory responses, conditions caused by the pro-duction of mediators and select inflammatory cytokines[1,2].Interleukin-6 (IL-6), interleukin-8 (IL-8) , and ... and autoimmune diseases. Human mast cells play an integralrole in the inflammatory response by accumulating atsites of inflammation and mediating the production ofinflammatory cytokines [35]. In ... AS, Brenner DA,Sartor RB: Curcumin blocks cytokine-mediated NF-kappa Bactivation and proinflammatory gene expression by inhibit-ing inhibitory factor I-kappa B kinase activity. J Immunol 1999,163:3474-3483.42....
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Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"
... prepared using heated processing conditions to substantially inactivate hemagglutinat-ing activity (HA) and trypsin inhibiting activity (TIA) while preserving alpha-amylase inhibiting ability. ... to follow the nutritionist’s recommendations. The candidates were entered into a 2-week single-blinded, run -in to en-rollment and randomization. Subjects in this run -in period unknowingly ... effects. Statistical Analysis To minimize differences in beginning values be-tween subjects, they were stratified into two groups very similar in size, age, gender, and body weight dis-tribution....
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