Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
... pretreatment results in an inhibition of inflammatory signaling in cells with CF defects. Production of IL-8 and other pro-inflammatory cytokines is also governed by mechanisms regulating in their mRNA ... extracellular-regulated protein kinase (ERK) cascades are active by phosphorylation through dual specificity MAPK kinases (MKK) and may all contribute to IL-8 expre...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Airflow limitation or static hyperinflation: which is more closely related to dyspnea with activities of daily living in patients with COPD?" ppt
... reported that indices related to hyperinflation, such as the inspiratory capacity (IC), are more closely related to exercise tolerance and dyspnea than the forced expiratory volume in 1 second ... static lung hyperinflation estimated by the inspiratory capacity to- total lung capacity (IC/TLC) ratio is a predictor of all-cause and respiratory mortality in patients with COPD,...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo khoa học: cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation potx
... Epac, may instead activate a tyrosine phosphatase which results in the observed decrease in both basal and CSF-1-induced tyrosine phosphorylation. In contrast to the data for EGFR-dependent tyro- sine ... monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine monophosphate. Blood 79, 1972–1981. 9 Vairo G, Argyriou S, Bordun AM, Whitty G & Hamil...
Ngày tải lên: 16/03/2014, 22:20
Báo cáo y học: "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood" ppt
... bone marrow cavity in chronic inflammatory arthritis. Introduction TNF is a clinically validated etiological factor in inflammatory- erosive arthritis and is known to synergize with RANKL and macrophage ... in inflammatory osteolysis. Arthritis Res Ther 2006, 8:201. 2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone di...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... F, Ficheux H, Pujol JP: Rhein inhibits interleukin-1 beta-induced activation of MEK /ERK pathway and DNA binding of NF-kappa B and AP-1 in chondro- cytes cultured in hypoxia: a potential mechanism ... growth factors, cytokines, proteases, and inflammatory mediators. The levels of alkaline phosphatase, osteocalcin, type I collagen, interleukin (IL)-6, transforming growth factor-...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot
... signals in macrophages [7]. The two pro- inflammatory enzymes, induciblenitricoxidesynthase (iNOS) and cyclooxygenase-2 (COX-2), which can be induced by LPS or cytokines, are found to work in concert in ... the production of inflammatory cytokines, chemokines, and proinflamma- tory enzymes (e.g. iNOS and COX-2) [38-40]. The pro- moter of the iNOS and COX-2 genes are know...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: " Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis" doc
... expres- sion in joints affected by AIA on Day 1. Abundant stain- ing was detected in the synovial lining layer, joint exudate and focal areas of synovial infiltration; it was comparable in WT and IFN-γ-/- ... IL-1β induced MMP secretion by RA FLS In RA cartilage damage is predominantly mediated by the MMPs; most notably MMP-1, -13 and -3 [19]. Their syn- thesis is driven by pr...
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: "Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway" pot
... play in allergic, asthmatic, and inflammatory responses, conditions caused by the pro- duction of mediators and select inflammatory cytokines [1,2]. Interleukin-6 (IL-6), interleukin-8 (IL-8) , and ... and autoimmune diseases. Human mast cells play an integral role in the inflammatory response by accumulating at sites of inflammation and mediating the production of inflammatory...
Ngày tải lên: 13/08/2014, 13:22
Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"
... prepared using heated processing conditions to substantially inactivate hemagglutinat- ing activity (HA) and trypsin inhibiting activity (TIA) while preserving alpha-amylase inhibiting ability. ... to follow the nutritionist’s recommendations. The candidates were entered into a 2-week single-blinded, run -in to en- rollment and randomization. Subjects in this run -in period...
Ngày tải lên: 31/10/2012, 15:12