Báo cáo y học: " Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts" pdf
Báo cáo y học: " Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts" pdf
... studies of disease-related abnormalities in the kynurenine pathway of tryptophan degradation.Keywords: human, fibroblast, kynurenine pathway, gene expression, cytokineIntroductionThe kynurenine pathway ... 8:25http://www.journal-inflammation.com/content/8/1/25Page 7 of 7RESEARCH Open Access Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblastsLinnéa Asp1, Anne-Sofie Johansson1, Amandeep ... transcripts encoding enzymes in the kynurenine pathway in human skin-derived fibroblasts from 7individuals. Transcripts encoding the following enzymes wereinvestigated; Indoleamine 2,3-dioxygenase 1...
- 7
- 457
- 0
Báo cáo y học: "Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts" pot
... abnormalities in the kynurenine pathway of tryptophan degradation.Keywords: human, fibroblast, kynurenine pathway, gene expression, cytokineIntroductionThe kynurenine pathway (KP) is the main route of ... Access Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblastsLinnéa Asp1, Anne-Sofie Johansson1, Amandeep Mann1, Björn Owe-Larsson2, Ewa M ... rate-limiting step of this pathway and is highly induced by the pro-inflamma-tory cytokine interferon (IFN)-g [22,23]. However, it isnot clear if pro-inflammatory cytokines affect expression of genes...
- 7
- 360
- 0
Tài liệu Báo cáo Y học: Purification, characterization, cloning, and expression of the chicken liver ecto-ATP-diphosphohydrolase pot
... hydrolysis by 70% whereasATP hydrolysis was inhibited by only 10%. Inhibition of ADP and ATP hydrolysis by azide was greater when the pH of assay solutions was 6.4. Azide inhibition was diminishedif ... chromatogra-phy buffer, buffer containing 0.5MNaCl, and buffer again.The enzyme was eluted with 50 mMglycine, pH 2.5containing 0.1% NP-40. Fractions of 1 mL were collectedinto tubes containing 0.1 ... Enzyme assays were carried out in 0.25-mLreaction mixtures using a wide-range buffer system (piperazinedihydrochloride/glycylglycine/NaOH [31]), covering the pH range of 4.6–9.5. The assay solutions...
- 10
- 694
- 0
Báo cáo y học: "Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages" docx
... the effects of im-mune-modulating cytokines on protein expression but focused on the effects on TLR mRNA expression. Pro-inflammatory cytokines may also control protein ex-pression of TLRs on ... anti-bacterial innate immunity surveillance. Alterna-tively, they suggest that separate expression control of TLR5 by inflammatory cytokines may contribute to regulation of innate immunity in monocytes ... of pro-inflammatory cytokines in regulation of TLR ex-pression remains unclear and discrepant in previous reports.[16, 17, 22, 37-40] Pro-inflammatory cytokines, such as granulocyte colony-stimulating...
- 8
- 349
- 0
Báo cáo y học: "Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes" pps
... IL-1β.Inhibition of iNOS by actinomycin and cycloheximide mayreflect, at least in part, inhibition of AP-1 complex synthesis,normally induced by BCP crystals.Conclusion In summary, this study ... andone is inducible (iNOS or NOS-2). Expression of iNOS hasbeen demonstrated in various cell types. Within the joint,chondrocytes may be the main cell source of NO, and iNOS expression is increased ... consistently described in chondrocytestreated with various inflammatory cytokines, including inter-feron-γ, TNF-α and IL-1β [43,62,63]. IL-1β seems to be thekey cytokine in the induction of...
- 12
- 388
- 0
Báo cáo y học: "Early Differential signaling mechanisms regulate expression of CC chemokine receptor-2 during monocyte maturatio" ppsx
... tissues.PMA-treatment of monocytes induces selective downregulation of CCR2Based on the above results we decided to further examinethe regulation of CCR2 expression in monocyte matura-tion using the human monocyte ... granularity of the cells. In addi-tion, we demonstrated an up-regulation in expression of genes associated with monocyte differentiation, notablyCD11b, CD36 and CD68. Concomitantly, the expression of ... blood monocytes and monocyte-derived macrophages are keyregulatory components in many chronic inflammatory pathologies of the vasculature including theformation of atherosclerotic lesions. However,...
- 14
- 285
- 0
Báo cáo y học: "Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D" pps
... Themetabolic pathways of pulmonary type II epithelial cellsmay be affected by secondary inflammatory mediators,such as TNF-α or IL-1β, secreted by inflammatory cellsduring C. posadasii infection. A ... individuals againstCoccidioides [5,6]. However, information is lacking regard-ing the pulmonary innate immune components that mayplay a critical role in regulation of immune responsesagainst Coccidioides.At ... metabolic dysfunction of pulmonary type II epithelial cells during C. posadasii infec-tion or due to their utilization in the binding and uptake of C. posadasii by local antigen presenting cells....
- 8
- 229
- 0
Báo cáo y học: "Cerebellum-specific and age-dependent expression of an endogenous retrovirus with intact coding potential" pdf
... strand (46 conversion positions vs. 23 no conversion positions) and minus strand (75 conversion positions vs. 63 no conversion positions). In addition, the average number of converted cytosine 22the ... brain stem, hippocampus, and olfactory bulb). In particular, significant difference in the frequency of cytosine to thymine conversion (red half-circle) or in the frequency of no conversion ... Cerebellum-specific methylation pattern of the ERVmch8 locus. A. The cytosine methylation profile of ERVmch8 in the cerebellum was compared to the methylation profile of an amalgamation of other brain compartments...
- 35
- 324
- 0
Báo cáo y học: "Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill" pptx
... effect of hyperlactatemia on mortality.Materials and methodsStudy populationThe patients included in the study were from a regional healthcare system including the city of Calgary and surroundingsmaller ... hours of ICUadmission were considered to not exhibit hyperlactatemia.Severity of illness at inception (within the first day of ICUadmission) was assessed using the Acute Physiology andChronic ... [27].Conclusions In summary, we demonstrate that hyperlactatemia is commonand associated with adverse outcome. Inclusion of hyperlac-tatemia adds to the prediction ability of the existing APACHEII...
- 5
- 327
- 0
Báo cáo y học: "Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis" ppsx
... TNF-αresulted in a strong induction of IL-32 mRNA expression as compared with stimulation with only one of these cytokines. This synergistic effect was observed in IL-32mRNA 4 h and 24 h after activation ... amplification of inflammatory reactions in RA, by expressing IL-32,which in turn induces the expression of TNF-α, IL-1, orIL-18 by macrophages or dendritic cells, bridging innateand adaptive immunity. ... release by activatingTLR pathways.ConclusionsIL-32 is known to activate the p38MAPK and the NF-κBsignal-transduction pathways and to induce the expres-sion of other proinflammatory cytokines, ...
- 11
- 272
- 0
Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ