Báo cáo y học: "Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-B-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA" ppsx

... Access Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-B-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA Akinbolade O Oyegunwa, ... play a key role in the transcriptional activation of cytokine genes after LPS stimulation [25]. Ther efore, we hypothesize d, t...

Ngày tải lên: 11/08/2014, 03:20

... integrity and the development of OA, this study suggests that dietary modification of fatty acid intake may be one strategy in the prevention of knee OA which warrants further investigation. Introduction Nutritional ... polyunsaturated fatty acids was not significantly associated with the incidence of BMLs. Conclusions Increased fatty acid consumption may increase the ri...

Ngày tải lên: 09/08/2014, 14:20

... addition, the system presents similar energy stabilization with respect to the DNA transcription factor complex. Finally, the compari- son of the relative orientation of the two subunits, both in the solid-state ... performed by energy minimizations and molecular dynamics simulations [30,31]. Furthermore, the conforma- tional behaviour and the thermal stability of...

Ngày tải lên: 24/03/2014, 04:21

... production was totally abolished when 99.9% of the monocytes were depleted. Conversely, when monocytes in the PBMC cultures were enriched from 7.5% to 54.7% mono- cytes, the TNF-α levels induced by ... Groschinsky Foundation, the Grönberg Foundation, the Bergvall Foundation, the Dahlin Foundation, the Carlsson Foundation, the Viberg Foundation, the Nanna Svartz Foun...

Ngày tải lên: 09/08/2014, 07:20

... pathway rather than the MEK/ MAPK pathway. Cyclin B 1 and cyclin D 1 Consistent with the increased chondrocyte growth, the expression of the cell proliferation markers cyclin D 1 and cyclin B 1 ... using week 1 and week 2 postcultures to evaluate the expression of the chondrocyte phenotype and also to assess the type-II and type-IX collagen production levels. The...

Ngày tải lên: 09/08/2014, 10:23

... analysis on one of the overexpressing clones (Runx1) by the high-resolution 2DGE method. The com- parison of the effect on the proteome with the effect on the transcriptome showed a strong correlation, ... gene targets and the elucidation of the transcriptional network underlying gene function. Only a subset of 7 out of 20 genes in our overexpression st...

Ngày tải lên: 09/08/2014, 20:22

... reconstruction [1,2]. We describe the case of a complicated sternal dehiscence, treated with the implant of the Strasbourg Thoracic Osteosyntheses System (STRATOS) and the transposition of the ... the bone quality is poor or there are multiple fractures of the sternum, these classical approaches of rewiring can fail and the rigid fixation systems, recently introd...

Ngày tải lên: 10/08/2014, 09:22

... effects on the production of anti-DNA Abs. No signs of glomerulonephritis in phytol-treated mice Further evaluation of safety and toxicity was assessed by histopathology of the kidneys from mice ... immunity was assessed in terms of titer, specificity, and isotypic profiles. The effect on cell-mediated immunity was studied by assaying the induction of either...

Ngày tải lên: 11/08/2014, 10:23

... nephrostomy and a guided aspiration of the fluid collection. This yielded thick pus from the collection and clear urine via the nephrostomy. A subsequent microbiological analysis of the pus and urine ... ureter joining at the pelvo-ureteric junction (PUJ). The lower moiety was moderately hydronephrotic and had a PUJO configura- tion. The upper moiety was non-hydron...

Ngày tải lên: 11/08/2014, 21:22