Báo cáo y học: "Increased levels of circulating Annexin A5 in Familial Mediterranean fever " ppt

... based upon flow-cytometry data indicating increased rate of apoptosis of subpopulations of leukocytes involved in autoinflammation and recur- rent episodes of fever in FMF [7]. In addition, our ... since it preferentially binds PS with high affinity and inhi- bits apoptotic cell uptake by phagocytes [12,13]. ANX-V is produced by a variety of cells and is an in vivo marker...

Ngày tải lên: 11/08/2014, 03:20

... the mechanisms by which this defect causes inflammatory attacks are largely unclear [1,2]. Pyrin contains a 92-aminoacid N-terminal pyrin domain that is shared by a number of other proteins involved in apoptotic ... Mediterranean fever is characterized by the increased levels of circulating Annexin A5, which is higher in patients within the attack and which associate with t...

Ngày tải lên: 11/08/2014, 06:22

... consumed by sPLA2. This enzyme is increased in level and activity in some inflammatory diseases and catalyzes hydrolysis of aminophos- pholipids, including PS, as well as phosphatidylcholine and phsophatidylethanolamine, ... nega- tive controls of annexin V ligation were used: MPs incubated with annexin V in a calcium-free buffer (to prevent annexin V ligation to PS) or withou...

Ngày tải lên: 09/08/2014, 14:22

... smokers), included in the study, are shown in table 1. Healthy individuals were slightly younger than the COPD patients, which was mainly caused by the young age of the healthy smokers. Addition- ally, ... counted using a Sysmex pocH-100i cell counter (Sysmex, Roche, Germany). Cells were used for flow cytometry and immu- nocytochemical staining on cytospins. Flow cytometry analysis Two...

Ngày tải lên: 12/08/2014, 14:20

... multi-organ dys- function. A balance between pro-inflammatory and anti- inflammatory effects is observed in the course of acute lung injury. Sustained high levels of pro-inflammatory Figure 2 Levels of ... being strongly associated with mortality occurring during ARDS [21,22]. T o assess if levels of micropar ticles may reflect some part of ventila- tory induced lung injury,...

Ngày tải lên: 14/08/2014, 07:21

... not shown). Since inflammation may be playing a role in progression of atherosclerosis, we examined whether the erythrocyte sedi- mentation rate (as a continuous variable) at the time of PMR diagnosis ... PMR have laboratory evidence of an acute phase response, includ- ing elevation of the erythrocyte sedimentation rate and C-reac- tive protein (CRP). Synovitis in proximal joints...

Ngày tải lên: 09/08/2014, 14:20

... 3 Representative analysis of intracellular Cytotoxic T Lymphocyte Antigen- 4 (CTLA-4) expression in peripheral blood lymphocyte subsetsRepresentative analysis of intracellular Cytotoxic T Lymphocyte Antigen- ... between soluble Cytotoxic T Lymphocyte Antigen- 4 (sCTLA-4) and clinical index of disease activity Bath Ankylosing Spond-ylitis Disease Activity Index in 165 patients with s...

Ngày tải lên: 09/08/2014, 14:22

... details 1 Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. 2 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Albe rta, ... patients and were involved in writing the paper. KN and KC were involved in designing the methods for collecting, analyzing and interpreting data, and helped putting the data...

Ngày tải lên: 13/08/2014, 01:20

... within 30 min and 45 min, respectively, of dosing with hydroxybupropion HCl 75 mg/kg. In addition, clin- ical signs, including ataxic gait, catatonia, changes in activ- ity, and changes in respiration ... liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice, namely erythrohydrobu...

Ngày tải lên: 08/08/2014, 23:21

... changing, roles in the overall patho- genesis of this form of arthritis. In the light of the findings presented by Kim and colleagues [1], it is interesting that a small number of studies have ... disease severity [5]. In another study, EAE failed to resolve in TNFα -/- or TNFR -/- mice, suggesting that TNFα plays an important role in resolution of inflammation [6]. In m...

Ngày tải lên: 09/08/2014, 10:23