Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt

... com- plexes and thereafter their roles in disease. In summary cigarette smoke exposure reduced HDAC- 2 activity and the expression of mSin3a and Mi-2α in the lungs of smoke exposed mice. This may contribute ... either the composi- tion or the stepwise construction and targeting of the mSin3a and Mi-2 co-repressor complexes or their role in disease....

Ngày tải lên: 11/08/2014, 03:20

... the original work is properly cited. Research Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid ... hormone receptors including the glucocorticoid receptor α (GRα) [10-15]. HDACs function by deacetylating of key compo- nents of the transcriptional ma...

Ngày tải lên: 11/08/2014, 06:22

... acquisition and analysis of data. TM has been involved in drafting the manuscript and revising it critically. GB participated in the critical reading of the manuscript. KT has been involved in the conception ... immune response [16]. The involvement of DC in the observed pathology is suggested by the significant increase of DC in both BALF and lung tissue...

Ngày tải lên: 12/08/2014, 16:20

... amylose continues to accumulate at the final stage of starch synthesis in the absence of concomitant amylopectin synthesis (reviewed in [41]). In vitro synthesis of amylose Because in Chlamydomonas ... and we can only state that the latter certainly does not exceed the rate of amylopectin synthesis. The increase in crystallinity wit- nessed during these first 12 h...

Ngày tải lên: 22/02/2014, 07:20

... Side-chain packing in the regions responsible for the stability of HT c-552, and the corresponding regions in the wild-type PA c-551 and its quintuple mutant. The mutated residues in the quintuple ... noncovalent interactions. We further found that the increase in the stability of the quintuple mutant is almost the same as the sum of the three individ...

Ngày tải lên: 24/03/2014, 03:21

... Consideration of the potential role of protein disorder may give novel insights into the possible role of molecular mimicry in the pathogenesis of autoimmunity. The recognition of extreme autoantigen ... as link- ers connecting domains of topoisomerase I that interact with opposite sides of the DNA; they may be unstructured in the apoprotein and become ordered...

Ngày tải lên: 09/08/2014, 07:20

... with induction of T-cell tolerance and immune inhibition in the induction of oral tolerance in the murine CIA model. We examined the change in the expression of IDO in CD11c + DCs of Peyer's ... activity in the small intestine and the epididymis of mice. Arch Biochem Biophys 1980, 203:343-351. 33. Malina HZ, Martin XD: Indoleamine 2,3-dioxygenase: ant...

Ngày tải lên: 09/08/2014, 10:22

... neck extending from the upper neck to the supraclavicular fossa. The mass was soft, compressible, non-tender, and fixed. There were no associated changes in the overlying skin. The remainder of the physical ... large cystic neck mass and was confused with a cystic hygroma. Her mother reported a progressive increase in the size of this swelling and mild respiratory...

Ngày tải lên: 10/08/2014, 23:21

... more inflammatory mediators and help modulate the inflammatory response? Unfortunately, there is no direct evidence that increasing the Q UF increases cytokine removal with CVVH. Indeed, the available ... Reiter, Rinaldo Bellomo and Claudio Ronco The sepsis syndrome is associated with an overwhelming systemic overflow of pro-inflammatory and anti-inflammatory mediators, lead...

Ngày tải lên: 12/08/2014, 18:21

... am Main and was internally funded. The study is independent of any pharmaceutical interest. Author details 1 Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital ... [8,21-23] and for the detec- tion of cytokines in the BAL in the context of ventilator-associated lung injury [24]. No data exist, however, on whether the technique...

Ngày tải lên: 14/08/2014, 08:21