Báo cáo y học: "Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages" pot

... translocation of HMGB1 in mϕ. Release of HMGB1 contributes to Fas-induced pro- inflammatory cytokine production by mϕ Both Fas and HMGB1 have previously been shown to induce pro-inflammatory cytokine ... significant. Results Activation of Fas induces rapid release of HMGB1 from viable mϕ Treatment with recombinant mFasL (0 - 0.5 μg/ml) induced release of HMGB1,...

Ngày tải lên: 11/08/2014, 03:20

... work is properly cited. Research Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages Feng Wang 1 , Ziyue Lu 1 , Michael Hawkes 1 , Huan Yang 2 , Kevin ... significant. Results Activation of Fas induces rapid release of HMGB1 from viable mϕ Treatment with recombinant mFasL (0 - 0.5 μg/ml) induced release of HM...

Ngày tải lên: 11/08/2014, 06:22

... secretory cell hypertrophy was observed. It is suggested that, the inflammatory cells/mediators, the epithelial damage and secretory cell hypertrophy contribute to initiation of airway hyperresponsiveness. Conclusion: ... into elementary bodies that are released after lyses of the infected cell and may infect other cells. It is likely that the afore mentioned process and the release of...

Ngày tải lên: 12/08/2014, 15:21

... the proximity of virus or virus-infected kerati- nocytes to target T-cells [32,62], release of pro-inflamma- tory cytokines [63] and activation of TLR-dependent signaling pathways by bacteria ... transcytosis of R5-tropic human immunodefi- ciency virus across tight monolayer of polarized human endometrial cells under pro-inflammatory conditions. Cytokine 2002, 20(6):289-294. 33....

Ngày tải lên: 13/08/2014, 06:20

... Electron spinresonancestudyoftheroleofnitricoxideandcatalaseinthe activation of guanylate cyclase by sodium azide and hydro- xylamine. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives. ... Mechanism of Oxygen Activation (Hayaishi, O., ed.), pp. 559–613. Academic Press, New York. 24. Yamada, H., Makino, R. & Yamazaki, I. (1975) Effects of 2,4-substituen...

Ngày tải lên: 08/03/2014, 16:20

... number of calls uniquely identified by the SNP- genotyping microarrays, and we identified 12 and 0 novel SVs contributed by Affymetrix 6.0 and Illumina 1 M, respectively. Of the 12 new Affymetrix ... HP, Yoo YJ, Shin JY, Kim HJ, Yavartanoo M, Chang YW, Ha JS, Chong W, Hwang GR, Darvishi K, Kim H, Yang SJ, Yang KS, Hurles ME, Scherer SW, Carter NP, Tyler-Smith C, Lee C, Seo JS: Discovery...

Ngày tải lên: 09/08/2014, 20:22

... structures may cause symp- toms such as dyspnea, chest pain, cough, and fatigue. Uncommonly hypertrophic pulmonary osteoarthropathy and hypoglycemia are also caused. Hypertrophic osteoar- thropathy, called ... are at risk of recurrence many years after surgery. Consent Written informed consent was obtained from the patient for publication of this case report and any accompany- ing image...

Ngày tải lên: 10/08/2014, 09:22

... and mass spectrometry genotyping technologies have been intro- duced to simultaneously determine the genotype of large numbers of SNPs [16–18]. It is not yet clear which of these ... in genotyping techniques and bioinformatics, enabling detection of single-nucleotide polymorphisms, already provide physicians and scientists with tools that change our understanding of human biology....

Ngày tải lên: 12/08/2014, 18:21

... College London; 2001. 14. Kosakovsky Pond SL, Frost SDW, Muse SV: HyPhy: hypothesis testing using phylogenies. Bioinformatics 2005, 21:676-679. 15. Kosakovsky Pond SL, Posada D, Gravenor MB, Woelk ... replication, we should expect higher ratios of nonsynonymous (amino acid changing) to synonymous nucleotide substi- tutions (d N /d S ) [5-8] than in viral samples isolated from vaccinated...

Ngày tải lên: 12/08/2014, 23:21

... Hospital, The University of Sydney, Darcy Road, Westmead, N.S.W 2145, Australia and 4 University of Western Sydney, Penrith South DC, N.S.W 1797, Australia Email: Leon Caly - leon.caly@med.monash.edu.au; ... progression, further anal- ysis of Vpr F72L in a HIV infectious system is required, eg. to dismiss the possibility that the effects in terms of lack of assembly of Vpr F72L...

Ngày tải lên: 13/08/2014, 05:21