Báo cáo y học: ": Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes" doc

... next evalu- ated the capability of the ASC isoforms to interact with caspase 1. Because activation of caspase 1 would result in proteolytic cleavage of the CARD of pro -caspase 1, we expressed the ... 430:213-218. 17. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, et al.: ASC is essential for LPS-induced activat...

Ngày tải lên: 11/08/2014, 03:20

... the 5¢ region of the Fe-hydrogenase from bacteria. Analysis of the hydA cDNA and genomic sequences A kgt11 cDNA expression library was c onstructed u sing poly (A) + RNA from anaerobically adapted ... cloning and sequencing A cDNA library was constructed u sing the Stratagene ZAP Express cDNA synthesis Kit (Stratagene, La Jolla, CA, USA) with 5 lg mRNA of anaerobically adap...

Ngày tải lên: 08/03/2014, 22:20

... Applied Biosystem, CA, USA). The TaqMan probe carries a 5′ FAM (6-carboxy-fluorescein) reporter dye and a 3′ TAMRA (6-carboxy-tetramethyl-rhodamine) quencher dye (Mega Bases, Chicago, IL, USA) ... USA) The quantity of cDNA of the gene of interest was directly related to the fluores- cence detection of FAM after 40 cycles. The amount of cDNA was calculated using a com...

Ngày tải lên: 09/08/2014, 03:24

... MΦs. Arthritis Research & Therapy Vol 9 No 5 Shahrara et al. Page 10 of 10 (page number not for citation purposes) 36. Tanaka S, Takahashi N, Udagawa N, Murakami H, Nakamura I, Kurokawa T, Suda T: Possible ... sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase. J Clin Invest 1998, 102:881-892. 20. Nakagawa M, Kaneda T, Arakawa T, Morita S,...

Ngày tải lên: 09/08/2014, 10:21

... patients. The accumulated data raise the possibility that altered expression of hRasGRP4 occurs in a subset of RA patients. Materials and methods Healthy individuals and patients with RA and other ... that participate in synovial inflammation and hyperplasia [23-25]. Thus, MCs and myeloid cells play pivotal roles in the pathophysiology of RA. In the present study, we...

Ngày tải lên: 12/08/2014, 18:20

... Tyr50 a Ala59 3.5H Tyr50 a Ala59 2.6H Tyr50 b Ala59 3.5H Tyr50 b Ala59 b 1 Tyr50 a 1 Gly56 b 2 Tyr50 a 1 Gly56 b 1 Tyr50 a 2 Gly56 b 2 Tyr50 a 2 Gly56 b 1 Tyr47 b Glu58 b 2 Tyr47 b Glu58 3.5H Tyr47 ... a semipreparative Vydac C 18 column using a linear gradient of acetonitrile. An experimental mass of 11 431.92 Da was obtained by electrospray mass spectroscopy and a mass...

Ngày tải lên: 31/03/2014, 23:20

... present ear anomalies, typical of CHARGE (coloboma of the eye, heart defects, atresia of the choanae, retardation of growth, genital abnormalities, and ear abnormalities) and OAVS (oculo- auriculo-vertebral ... (vertebral anomalies, anal atresia, cardiovascular anomalies, trachea-esophageal fistula, esophageal atresia, renal and/or radial anomalies and limb defects) syndrome, Fein...

Ngày tải lên: 10/08/2014, 23:22

... neuromuscular activation processes. This approach may also prove very useful to evaluate pharmaceutical treatments of the OSAS aimed at modu- lating the activity of UA dilator during sleep. Abbreviations APB: ... OSAS patients. For instance, an OSAS-related increase in the tidal phasic activity of these muscles has been inter- preted as compensatory of smaller pharyngeal dimen-...

Ngày tải lên: 12/08/2014, 14:20

... http://arthritis-research.com/content/4/3/209 Supplementary Table 1 Details of RA and non-RA patients Gender Age Diagnosis/pathology Disease duration (years) Medication 1. Female 71 RA 7 An 2. Male 61 RA 20 St 3. Female 67 RA 7 St, NSAID 4. Male ... significant dis- ability. Central pathophysiological features of the disease occur in the synovium, with thickening of the lining lay...

Ngày tải lên: 09/08/2014, 03:24