báo cáo khoa học: "Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literature" pot

... 4:307http://www.jmedicalcasereports.com/content/4/1/307Page 4 of 4CAS E REP O R T Open AccessElevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literatureShuhei Yoshida1,2*, Masahiko ... of the liver was higher than that of the spleen in a patient with AN and elevated transaminases, wherea sliver steatosis was diagnosed in ultrasound imaging, as was found in our patient. In addition, ... Medicine, TMG Asakadai CentralGeneral Hospital, Saitama 351-8551, JapanFull list of author information is available at the end of the articleYoshida et al. Journal of Medical Case Reports 2010,...

Báo cáo khoa học: Distinct but critical roles for integrin aIIbb3 in platelet lamellipodia formation on ﬁbrinogen, collagen-related peptide and thrombin pot

... pathwayssuch as activation of the capping protein gelsolin [10] and myosin light chain kinase. Intracellular Ca2+wasmeasured by loading with the calcium reporter dyeOregon Green-BAPTA 1-AM and monitoring ... distinct pattern of intracellular Ca2+signalling wasobserved in platelets on thrombin. An initial rapid ele-vation in intracellular Ca2+was followed by a sus-tained phase of increased Ca2+levels ... promote a conformationalchange in the extracellular domain, leading to anincrease in afﬁnity, thereby promoting integrin–ligandinteractions [2]. In turn, clustering of integrins gene-rates a series...

Báo cáo khoa học: " Host Immune Responses Against Hog Cholera Virus in Pigs Treated with an Ionized Alkali Mineral Complex" pot

... vaccination pigs were variable in the level of maternal antibody titers (<1:4~1:256). Mean antibodytiters of each group against HCV increased gradually after the vaccination of the attenuated ... one of the major diseases that are threatening the expandingKorean swine industry since 1947 [7]. Thus, the nationaleradication program of a virulent hog cholera virus infection in the industry ... daysold and the second vaccination at 60 days old, with annuallybooster injection for adults. Since December, 2001 the Korean government has ceased vaccination policy againsthog cholera. As a nonspecific...

Tài liệu Báo cáo khoa học: Pharmacologic chaperoning as a strategy to treat Gaucher disease ppt

... concentration of partially active GC vari-ants, as demonstrated by increased cellular GC activity,an increased concentration of lysosomal GC glyco-forms and increased colocalization of GC with the ... hydro-lase activity. That said, the fractional activity appearsto be sufﬁcient to ameliorate disease, when folding and trafﬁcking efﬁciency is increased, resulting in anincrease in the mutant ... MINIREVIEWPharmacologic chaperoning as a strategy to treat GaucherdiseaseZhanqian Yu, Anu R. Sawkar and Jeffery W. KellyDepartment of Chemistry and The Skaggs Institute for Chemical Biology,...

Tài liệu Báo cáo khoa học: Phage-display as a tool for quantifying protein stability determinants pptx

... and characterizingindividual mutant proteins, these combinatorial approachesoffer the important advantage of simultaneously generatinglibraries of protein variants, thus allowing a much largernumber ... bindingpartner (stability- or afﬁnity-based), one could divide a phage library in half and sort one half against a bindingpartner and the other half against an expression tag. A comparison of the ... association of the variable heavy chain (VH )with protein A was used as a surrogate for direct stabilitymeasurements. The VHdomains in camelid heavy chainantibodies are most similar to the...

Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc

... CP-pyk(5¢-ACGACTAGTGGATCCATNNNNNAGTTTATTCTTGACANNNNNNNNNNNNNNTGRTATAATNNNNAAGTAATAAAATATTCGGAGGAATTTTGAAATGAATAAACGTGTAAAAATCG-3¢)(N¼ A, T, G, C) and pyk-back (5¢-CTCTACATGCATTTCAACAATAGGGCCTGTC-3¢) ... (5¢-TGGTACTCGAGCAATTTCTGAAGGTATCGAAG-3¢) and pyk2 (5¢-GGAAGGATCCTTGTGTTTTTCTCCTATAATG-3¢) and downstream to pyk using primer pyk3 (5¢-GGAAGGATCCTTTGTCAATTAATGATCTTAAAAC-3¢) and pyk4(5¢-CTAGTCTAGATGAGCTCCAGAAGCTTCC-3¢) ... signiﬁcantly as the PKactivity was modulated. At increased PK activity wefound an almost proportional increase in formate and acetate production and a decrease in lactate produc-Fig. 2. Modulation of...

Tài liệu Báo cáo khoa học: "Sentence generation as a planning problem" pptx

... the atoms subst(S, 1.self) and step(1) and a ﬁnal state consisting of the following goal: A, u.¬subst (A, u) ∧ A, u.¬mustadjoin (A, u).We can then send the actions and the initial state and goal ... existence of the individual r before the utterancewe are generating. We model this by marking r as hearer-new in the pragmatic knowledge base and as- signing it an empty context set. In this case, the ... the planning operators. After a brief review of LTAG and PDDL, we ﬁrst focus on syntax alone and showhow to cast the problem of generating grammaticallywell-formed LTAG trees as a planning...

Tài liệu Báo cáo khoa học: Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells doc

... (LDA).Thisstatisticalmultivariate method is supervised. It searches for the variables containing the greatest interclass variance and the smallest intraclass variance, and constructs a linearcombination ... Manyparameters can be adjusted for increasing the efﬁciency of the algorithm. The data were analysed with a window of ﬁvewavenumbers, assuming that adjacent wavenumbers arehighly corr elated. A ... Natick,USA). Spectra were separated in a training set constituted of 48 samples o f the cell line A and a test set c omposed of 30spectra of cell line A and cell line B. The trainin g set was...

Báo cáo khoa học: 2-Pyrimidinone as a probe for studying the EcoRII DNA methyltransferase–substrate interaction docx

... stabilities of the adducts of C5 MTases with DNA duplexes containing AzaC, FC or2P in place of the target C in the presence of AdoMet. The adducts of M.EcoRII with AzaC DNA [5] and M.HhaI with FC DNA ... methyltransfer was detected in the case of duplex I lacking the HhaI recognition sequence (data not shown). Therefore, as in the case of M.EcoRII inhibition of M.HhaI by 2P wasaccompanied by a methyl ... group from the cytosineresults in an increase of reactivity at the C6 carbon atom in 2P and in a reduction of the energy barrier for base ﬂipping[7]. 2P replacing the target cytosine in the recognitionsequences...

Báo cáo khoa học: Missense mutations as a cause of metachromatic leukodystrophy Degradation of arylsulfatase A in the endoplasmic reticulum potx

... acid-substituted ASAsvia the proteasome In order to investigate the degradation pathway of amino acid-substituted ASAs in the ER, we used Ltk–Fig. 2. Immunoprecipitation of amino acid-substituted ASAs with structure-sensitive ... mechanisms causeASA deﬁciency. In about half of the examined cases the mutant enzymes are retained in the ER [2,9,10], in the other half, enzymes can leave the ER and be degradedafter arrival in ... mAbs A2 and A5 , and amino acid residues 202–206 by mAb C,respectively. For this reason the reduced reactivity of mAbs A2 and A5 with Gly86Asp and Arg84Gln sub-stituted ASA and mAb C with the...

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