báo cáo khoa học: "Uptake and fate of surface modified silica nanoparticles in head and neck squamous cell carcinoma" pps

... 9:32 http://www.jnanobiotechnology.com/content/9/1/32 Page 10 of 14 RESEARC H Open Access Uptake and fate of surface modified silica nanoparticles in head and neck squamous cell carcinoma Emina Besic Gyenge 1*† , Xenia Darphin 1† , Amina Wirth 2 , ... Uptake and fate of surface modified silica nanoparticles in head and neck squamous cell c...

Ngày tải lên: 11/08/2014, 00:23

... extent of tumour shown by imaging, including all involved (positive) lymph nodes. MRI, and in few cases FDG-PET, were used in the delineation of GTV. On the basis of the primary t umour size and involved ... receiving Cetuximab, administration was initiated one week before RT at loading dose of 400 mg/ mq of body surface area over a period of 120 minutes, followed by wee...

Ngày tải lên: 09/08/2014, 09:20

... (Oxis International Inc, Portland, OR, USA), follow- ing the manufacturer’s instructions. Culture of THP-1 cells and experimental protocol THP-1 monocytes were maintained in suspension in RPMI ... to surface remnants of triglyceride-rich lipoproteins. Arterioscler Thromb 14, 622–635. 14 Pal S, Semorine K, Watts GF & Mamo J (2003) Identi- fication of lipoproteins of intestin...

Ngày tải lên: 16/03/2014, 12:20

... FEBS monomers are involved in RNA binding, and disrup- tion of the orientation of the amino terminal hairpin by the C-terminal tail of the antitoxin inactivates the toxicity of the protein. The crystal ... that RNA binding to one of the symmetric binding surfaces introduces structural changes in the Kid protein that prevent the binding of a second substrate to the second sym...

Ngày tải lên: 18/02/2014, 04:20

... validated in vitro andusedtoexamine the branch-point kinetics in detail and to obtain insights into the kinetic controls of methionine and threonine synthesis in plants. The branch-point between ... divergence of two fluxes (fluxes of cystathionine and threonine) with the convergence of two fluxes (fluxes of Phser and cysteine). Interestingly, the properties of CGS are s...

Ngày tải lên: 20/02/2014, 02:21

... selective degradation of mRNA and inhibition of expression of the genes of ÔunwantedÕ proteins. The successful selection of hammerhead ribozymes, active in human cell lines, allows application of a molecular ... the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells. J. Biol. Chem. 276, 15378–153...

Ngày tải lên: 08/03/2014, 08:20

... functional testing of individual clones. In contrast, plasmids with an Epstein–Barr virus (EBV) origin of replication oriP in the presence of EBV-encoded EBNA-1 protein are continuously propagated in 1% of initially ... establish- ment of doxycycline-inducible protein expression by just a single transfec- tion. pEBTetD contains an Epstein–Barr virus origin of replication fo...

Ngày tải lên: 23/03/2014, 09:21

... inducer of cellulase activity in T. emersonii [54], and it has been postulated that sophorose could be the natural inducer of cellulase expression in T. reesei. Cellobiose is a poor inducer of ... to the cellulose-binding sites i n 1Q9H. This proposal is supported by the replacement of Asn7 in 1CEL by a smaller threonine residue in 1Q9H and 1GPI at the )7 subsite and of...

Ngày tải lên: 23/03/2014, 13:20

... catalysis of isolated CF 1. The N-terminal region of subunit c in CF 1 is not crucial for binding of subunit e in vitro. Further studies are needed to determine candidate residues participating in transmission ... hydrolytic activity. In vitro binding assays of e with c subunit and immunoblotting analysis Equal amounts of GST or GST–e fusion proteins were bound to glutathi...

Ngày tải lên: 23/03/2014, 13:20

... of Stx internalized in each cell line after 10 min at low toxin concentrations, ranging from 13% in A431 cells to 33% in BHK cells (internalized toxin as percent of total cell- associated toxin; ... endocytosis (% of total cell- associated toxin) 0 10 20 30 40 50 60 Non-induced cells Induced cells 01020 Fig. 4. Endocytosis of Stx in noninduced and induced BHK cells with...

Ngày tải lên: 23/03/2014, 15:20