báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx
báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx
... al.: Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice.Journal of Nanobiotechnology ... Open AccessHepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in miceSivasami Pulavendran1, ... levels of growth factors in the niche of injured microenvironment neces sitates the exogenous and sustainable delivery of growth factors along with stem cells to augment the regeneration of injured...
- 11
- 404
- 0
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf
... examples of latent growth factors have already been reported. Insulin-like growth factors are inactive when bound to insulin-like growth factor- binding proteins. Transforming growth factor- b ... activation of HGF in response to tissue injury In order to elucidate the in vivo roles of proteolyticprocessing of HGF, we examined the molecular forms of HGF by immunoblotting using a heavy chain-specific ... [11]. The antibody reactswith both the single-chain and two-chain forms of HGF, giving positive bands at 92 and 62 kDa, respec-tively. By scanning of the 92 and 62 kDa bands, the ratio of the single-chain...
- 7
- 502
- 0
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1) doc
... rapidly resynthesized, so that the intact form of the Kunitz domain inhibitor predominates in the crystal structure [35]. According to this model, the intact KD1 peptide bond in the KD1–HGFA ... predict, as in the case of the related aprotinin–prostasin complex, in which the 99-loop moves away from the substrate-bindingcleft to accommodate the Kunitz-type inhibitor aproti-nin [15]. In some ... because of the in uence of crystal packing in some of these structures. Other features seen amongincompetent active sites are not observed for HGFA,e.g. the loss of the oxyanion hole seen in Na+-freethrombin....
- 8
- 298
- 0
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt
... precursor [26]. In the absence of PCI, almost all of the single-chain HGF precursor was activated byHGFA, releasing the 98 kDa disulfide-linked activeform of HGF. In contrast, in the presence of PCI-pre-treated ... PCI-pre-treated HGFA, the single-chain HGF precursor wasminimally converted into the two-chain form.HGFA–PCI formation was competitively inhibitedby APC in the presence of heparin. PCI inhibits APCwith ... tar-gets of PCI in plasma, the effect of APC on HGFA–PCI formation was examined in the presence or absence of heparin. APC competitively inhibited HGFA–PCIformation in the presence of heparin, but...
- 7
- 291
- 0
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): pathophysiological functionsin vivo potx
... KLK5MacrophagesEpithelialcellsTumor cellsEndothelialcellsPlasmaTumor cellsEpithelial cellsInflammatory cellsTumor cellsEpithelial cellsPlasmaStromal cellsHAI-1HAI-2HAI-1HAI-2Protein CinhibitorStimulationHepsinHAI-1HAI-2EpithelialcellsStimulationFig. ... receptor, RON. Therefore, the pericellular activity of HGFA might be an important factor regulating the activities of these multifunctional cytokines in vivo. HGFA is secretedmainly by the liver, circulates ... understanding of the roles of HGFA in physiological and pathological settings.Synthesis and distribution of HGFA in vivoHGFA is secreted mainly by the liver, and circulates in the plasma as a single-chain...
- 8
- 270
- 0
Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx
... search for a role of HGFA in pro-MSP activation, we analyzed the processing of mouse pro-MSP in serafrom HGFA-knockout (HGFA)/)) mice. The proform of MSP was the predominant molecular form in the ... mechanical wound in the dorsalskin of mice and examined the in ltration of macro-phages by measuring the CD68 mRNA level. One dayafter injury, the levels of CD68 mRNA in the wounds of HGFA)/)mice ... Japan).Preparation of recombinant proteins The preparation of the recombinant active form of HGFAhas been described previously [19]. To obtain a recombinantpro-MSP protein, the entire coding region of the...
- 10
- 366
- 0
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... aC-terminal regulatory domain [2]. The extracellulardomain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and aC-lobe, and ATP binds to the cleft formed ... Uponbinding its ligands, dynamic conformational changes occur in both extra-cellular and intracellular domains of the receptor tyrosine kinases, resulting in the transphosphorylation of tyrosine ... because it stimulated the proliferation of epithelial cells [1]. In 1972, the aminoacid sequence of the EGF was determined. The pres-ence of a specific binding site for EGF, the EGF recep-tor...
- 8
- 684
- 0
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... result in repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and therebystabilize the interaction with EGF-TKIs, leading to anincrease ... the tyrosine kinase activity of EGFR (EGFR-TKIs), gefiti-nib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, therebyinhibiting receptor tyrosine kinase ... and small-molecule tyrosine kinase inhibitors, such as gefitinib and erlotinib, whichtarget the intracellular tyrosine kinase domain of the EGFR. Furthermore,recent clinical and laboratory studies...
- 7
- 511
- 0
Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... expression in a subset of human lung cancersTo gain further insights into the role of miR-125a-5p in lung carcinogenesis and to examine the clinical rele-vance of our findings, we investigated the ... the following day, 1 · 105cellssuspended in 0.1 mL of fresh medium without fetal bovineserum were added to the insert. Forty-eight hours afterseeding, the cells on the upper surface of the ... stimulation in all three cell lines, and that thiseffect was reversed by gefitinib. The value for miR-125a-5p in the EGF group was set at 1, and the relative amounts of miR-125a-5p in the other groups...
- 8
- 536
- 0
Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells doc
... cells.Referring to Smad4, there are significant levels of protein in the nucleus of both cell lines already in the absence of ligand. Cycloheximide treatment for 1 h prior to the addition of NGF indicated ... confocalmicroscopy. The projection of multiple sections is seen on the left for each panel to visualize the morphology of the cells. The middle row showsstaining of Smad3 and on the right an overlay of Smad3 ... place in the extracellular compartment, intracellular signaling eventsinitiated by autocrine TGF-b can be excluded. Takentogether, the effects of NGF on the Smad pathway areindependent of TGF-b...
- 12
- 539
- 0
Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ