báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx

... al.: Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice. Journal of Nanobiotechnology ... Open Access Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatoc...

Ngày tải lên: 11/08/2014, 00:23

... examples of latent growth factors have already been reported. Insulin-like growth factors are inactive when bound to insulin-like growth factor- binding proteins. Transforming growth factor- b ... activation of HGF in response to tissue injury In order to elucidate the in vivo roles of proteolytic processing of HGF, we examined the molecular forms of HGF by immun...

Ngày tải lên: 15/03/2014, 11:20

... rapidly resynthesized, so that the intact form of the Kunitz domain inhibitor predominates in the crystal structure [35]. According to this model, the intact KD1 peptide bond in the KD1–HGFA ... predict, as in the case of the related aprotinin–prostasin complex, in which the 99-loop moves away from the substrate-binding cleft to accommodate the Kunitz-type inhi...

Ngày tải lên: 15/03/2014, 11:20

... precursor [26]. In the absence of PCI, almost all of the single-chain HGF precursor was activated by HGFA, releasing the 98 kDa disulfide-linked active form of HGF. In contrast, in the presence of PCI-pre- treated ... PCI-pre- treated HGFA, the single-chain HGF precursor was minimally converted into the two-chain form. HGFA–PCI formation was competitively inhibited...

Ngày tải lên: 22/03/2014, 21:21

... KLK5 Macrophages Epithelial cells Tumor cells Endothelial cells Plasma Tumor cells Epithelial cells Inflammatory cells Tumor cells Epithelial cells Plasma Stromal cells HAI-1 HAI-2 HAI-1 HAI-2 Protein C inhibitor Stimulation Hepsin HAI-1 HAI-2 Epithelial cells Stimulation Fig. ... receptor, RON. Therefore, the pericellular activity of HGFA might be an important factor regulating the a...

Ngày tải lên: 22/03/2014, 21:21

... search for a role of HGFA in pro- MSP activation, we analyzed the processing of mouse pro-MSP in sera from HGFA-knockout (HGFA )/) ) mice. The proform of MSP was the predominant molecular form in the ... mechanical wound in the dorsal skin of mice and examined the in ltration of macro- phages by measuring the CD68 mRNA level. One day after injury, the leve...

Ngày tải lên: 29/03/2014, 23:20

... a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains. The tyrosine kinase domain consists of an N-lobe and a C-lobe, and ATP binds to the cleft formed ... Upon binding its ligands, dynamic conformational changes occur in both extra- cellular and intracellular domains of the receptor tyrosine kinases, resulting in the transpho...

Ngày tải lên: 16/02/2014, 09:20

... result in repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs, leading to an increase ... the tyrosine kinase activity of EGFR (EGFR-TKIs), gefiti- nib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby in...

Ngày tải lên: 16/02/2014, 09:20

... expression in a subset of human lung cancers To gain further insights into the role of miR-125a-5p in lung carcinogenesis and to examine the clinical rele- vance of our findings, we investigated the ... the following day, 1 · 10 5 cells suspended in 0.1 mL of fresh medium without fetal bovine serum were added to the insert. Forty-eight hours after seeding, the cells...

Ngày tải lên: 07/03/2014, 00:20

... cells. Referring to Smad4, there are significant levels of protein in the nucleus of both cell lines already in the absence of ligand. Cycloheximide treatment for 1 h prior to the addition of NGF indicated ... confocal microscopy. The projection of multiple sections is seen on the left for each panel to visualize the morphology of the cells. The middle row...

Ngày tải lên: 16/03/2014, 16:20