... found an inhibi-tory effect of APC on inducible NO synthase induction bydecreasing TNF-α production in rats with endotoxin-inducedhypotension; a similar action of APC in the impaired intestinalmucosa ... animportant role in the pathogenesis of this life-threatening dis-ease. Therefore, the effects of replacement of this mediator in ANP should be a focus of future investigations.Competing interestsThe ... Department of Microbiology, Gülhane School of Medicine, Etlik, Ankara, Turkey9Assistant Professor, Department of Internal Medicine, Gülhane School of Medicine, Etlik, Ankara, Turkey10Professor,...