báo cáo khoa học: "Molecular understanding of sterically controlled compound release through an engineered channel protein (FhuA)" pptx

... Molecular understanding of sterically controlled compound release through an engineered channel protein (FhuA). Additional file 1 contains a summary of kinetic data for TMB diffusion and experimental ... design and performed study, data analysis and drafting of the manuscript. MF and BH performed data analysis and drafting the manuscript. US carried out design, stu...

Ngày tải lên: 11/08/2014, 00:22

... most glyphosate-resistant biotypes. In the case of Conyza canadensis, glyphosate accumulates in vacuoles of resis- tant plants at a markedly faster rate than in sensitive plants [61]. Analysis of the transcriptome ... Arg111, and His138) and with the carboxylate end (Arg21 and Arg73) of GriP. Of partic- ular note is a short, 2.46-A ˚ hydrogen bond between N- e of His138 and a phos...

Ngày tải lên: 14/02/2014, 14:20

... of the MRS2 gene nearly abolished it [7]. Single channel patch-clamp- ing revealed the presence of a Mg 2+ selective channel of high conductance. This channel is made up of a homo- oligomer of ... protein- containing bands were visualized by use of an anti-HA serum (Covance Inc., Prince- ton, NJ, USA). Computer analysis Prediction of coiled-coil regions of Mrs2p and M...

Ngày tải lên: 23/03/2014, 10:21

Ngày tải lên: 07/08/2014, 18:21

... Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan 5 Department of Biotechnology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan Introduction Isovaleryl-CoA ... lysate; lane 2, proteins not binding to the column; lanes 3, 4 and 5, wash fraction (5, 20 and 40 m M imidazole, respectively) and lanes 6–10, eluate fraction (500 mM...

Ngày tải lên: 18/02/2014, 04:20

... alignment of the APUM proteins with the PUF domains most similar to Drosophila PUF domain. (A) APUM proteins of group I. (B) APUM proteins of group II. C. W. Francischini and R. B. Quaggio PUF proteins ... APUM proteins must function as translational regulators in a manner similar to that of other well- characterized members of PUF family. These proteins must bind to transcripts in...

Ngày tải lên: 18/02/2014, 06:20

... NMR and computational chemistry approaches to identify the molecular determinants of ligand specificity of CtCBM11. By means of NMR studies, we have analyzed various cello-oligosaccha- rides of ... kind of information and complement the NMR studies. These studies can provide localized structural information about the binding pocket of CtCBM11 and identify which atoms of the ligan...

Ngày tải lên: 18/02/2014, 17:20

... inflammation, cell proliferation and angiogenesis. To date, several animal studies and human studies have shown the biological efficacy of specific antagonism of ligands and receptors in RA [45,63]. ... susceptibility and severity. Conclusion Chemokines have an important role in the patho- genesis of RA by recruiting leukocytes and by control- ling other important processes, such as rel...

Ngày tải lên: 18/02/2014, 18:20

... hormones, pregnancy etc. have been extensively studied previously. Understanding of how these factors contribute to the development of RA may lead to the better understanding of pathogenesis of RA. Abbreviations AhR, ... 0.5–1% of the popu- lation and causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quali...

Ngày tải lên: 18/02/2014, 18:20

... tar- get genes, and an influx of Ca 2+ through Ca (2+) - release- activated Ca (2+) (CRAC) channels is required [27]. Pharmacologic inhibitors of NFAT translocation, such as tacrolimus (FK506) and cyclosporine ... pathology. Activator protein- 1 The activator protein- 1 (AP-1) transcription factor is composed of members of the Fos, Jun and activating transcription factor familie...

Ngày tải lên: 18/02/2014, 18:20