báo cáo khoa học: " Mode of antiviral action of silver nanoparticles against HIV-1" doc

... ability of PMT to discriminate among the different Ga isoforms, as all of the Ga subunits have analogous active site Gln residues (equivalent to Gln204 of Ga i1 , Gln205 of Ga i2 , Gln229 of Ga 12 ... of convergent toxin evolution. In this review, we focus on PMT and our current understand- ing of the structure–function, mechanism of action and cellular consequences of thi...

Ngày tải lên: 22/03/2014, 15:21

... virus (Table 1). Antiviral activity of silver nanoparticles and ions To define that the observed antiviral effect of silver nanoparticles is due to nanoparticles, rather than just silver ions present ... interaction. AIDS Res Hum Retroviruses 1990, 6:1281- 1287. doi:10.1186/1477-3155-8-1 Cite this article as: Lara et al.: Mode of antiviral action of silver nano...

Ngày tải lên: 11/08/2014, 00:22

... specificity of action of GE23077 on cellular RNA synthesis a nd strongly suggest that its restricte d antimicrobial activity is a result of i ts inability to cross bacterial membranes. Mechanism of action ... purified enzymes to obtain further insights into the mode of action of GE23077. Interestingly, the compound d isplays a behaviour similar to that of rifampicin, an an...

Ngày tải lên: 30/03/2014, 15:20

... the mechanism of action of vis- cotoxin isoform A 3 (VtA 3 ). We describe a detailed study of viscotoxin interaction with fungal-derived model membranes, its location inside spores of Fusarium ... genera- tion of H 2 O 2 in spores [9,15–18]. In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, by examining the int...

Ngày tải lên: 19/02/2014, 07:20

... °C. However, the interaction of ligands with cell surface receptors at 37 °C is a function not only of the rate constants of association and dissociation, but also of the endocytic rate constant, ... the LDL-binding domain of LDLR [18]. The molecular basis of the enhanced rate of dissoci- ation observed in the presence of unlabeled ligand is unclear. This phenomenon has often,...

Ngày tải lên: 14/02/2014, 14:20

... catalytic efficiency of PhyH-DII. Further- more, the catalytic efficiency of PhyH was much greater than that of PhyH-DI and PhyH-DII combined (5.73 fold) or twice the amount of PhyH-DII (5.45 fold). This ... ± 0.56 UÆmg )1 against d-Ins(1,4,5,6)P 4 at 35 °C and cannot hydrolyze other IPPs. The function of PhyH-DI in InsP 6 degradation When PhyH-DI was added into the reaction system...

Ngày tải lên: 14/02/2014, 15:20

... Acharya 1 1 Department of Biology and Biochemistry, University of Bath, UK 2 Department of Biochemistry, University of Wisconsin–Madison, USA 3 Department of Chemistry, University of Wisconsin–Madison, ... studies of the structure and binding sites of enzymes. 8. Inhibitor binding to ribonucleases. J Mol Biol 45, 491–511. 33 Ui N (1971) Isoelectric points and conformation of...

Ngày tải lên: 14/02/2014, 22:20

... transfer of phosphate esterified in the 5¢ position of 6-hydroxypu- rine monophosphate nucleosides [1]. The transfer of phosphate can lead to phosphorylation of inosine, guanosine and a number of their ... The structural model indicates that cN-II is a homotetrameric protein that results from interaction through a specific interface B of two identical dimers that have arisen from in...

Ngày tải lên: 15/02/2014, 01:20

... containing subunits of both PRTFDC1 and HPRT, thereby providing an addi- tional means of regulating the activity of HPRT. Recently, Suzuki et al. [9] showed that PRTFDC1 expression often was silenced ... elucidation of the structure of PRTFDC1 and the definition of its ligand binding specificity from a large metabolome library provides an initial start point for defining the molecula...

Ngày tải lên: 15/02/2014, 01:20