báo cáo khoa học: "Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides" pptx

... not for citation purposes)Journal of NanobiotechnologyOpen AccessResearchFormulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine) -poly(ethylene ... variable release kinet-ics and sizes [28,30-32]. Nanosized PLGA has beenformulated for encapsulation of naked plasmid DNA and AO [33,34]. Also, PEI has been successfully encapsulatedinto PLGA nanospheres ... sonication intensity and Release kinetics of PEG-PEI-AO polyplex from PLGA nanospheresFigure 5 Release kinetics of PEG-PEI-AO polyplex from PLGA nanospheres. Nanospheres were formulated with PLGA...

báo cáo khoa học: " All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein" pdf

... least by the down-regulation of survivin and up-regulation of Bax (Figure 3A and 3B). Even thoughXIAP and survivin belong to the same family of apoptoticinhibitors, it is likely that ATRA effected ... expression of survivin, XIAP and Bax proteinIt is well known that apoptoti c pro cess is regulated bymany factors. We investigated the expression of inhibitors of apoptosis, survivin, XIAP, and pro-apoptosis ... 29:165http://www.jeccr.com/content/29/1/165Page 7 of 8 of Medical Genome Sciences, Graduate School of Frontier Sciences, theUniversity of Tokyo, Tokyo, Japan.3Graduate School of Integrated Arts and Sciences, Doctoral Course,...

báo cáo khoa học: " Arabidopsis WRKY2 transcription factor mediates seed germination and postgermination arrest of development by abscisic acid" pdf

... This leads to the cessation of cell division and activation of genes encoding seed storage proteins and proteins required to establish desiccation tolerance [6].Exposure of seeds to ABA during ... expression of Em1 and Em6. wrky2 mutants and wild type showed similar levels of expression for miR159 and its target genes MYB33 and MYB101. Analysis of WRKY2 expression level in ABA-insensitive and ABA-deficient ... http://www.biomedcentral.com/1471-2229/9/96Page 8 of 14(page number not for citation purposes)RNA levels of ABI5, ABI3, Em1 and Em6 in wrky2 mutants and wild typeFigure 6RNA levels of ABI5, ABI3, Em1 and Em6 in wrky2 mutants and wild...

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... lack of dmrt1 in mutant mice caused a highincidence of teratomas and resulted in a failure of germ cells to arrest mitosis [56]. Thus, Dmrt1 in mice and similarly Dmrt1bY in medaka appear to be ... molecu-lar activity of Sry is translated into cellular structure and organ morphology. Interestingly, Dmrt1, theancestor of Dmrt1bY, is one of the downstream effec-tors of Sry in the male pathway.In ... gonadal differentiationlike, for example, Wt1, Sox-9, Bmps and Amh (see [3] for a review) are present in all vertebrates including ﬁsh[4] and for most of them even in protostomes.KeywordsDmrt1bY;...

Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc

... inter-ferons b and c) contain regulatory elements in the 3¢UTR that are important for the half life of cytokinemRNAs. For this reason, transcription of genes encod-ing cytokines is not sufﬁcient to guarantee ... dynamics and features of this protein.Role of MCPIP in regulation of the endogenousIL-1b transcript levelAfter identiﬁcation of a PIN domain in the MCPIP byuse of bioinformatics, we decided to ... served as a control for equal loading.A single 2.0 kb band was seen in all lanes. A 1.8 kb actin isoform is vis-ible for heart and skeletal muscle. The duration of exposure of theNorthern blot...

Tài liệu Báo cáo khoa học: "Collecting a Why-question corpus for development and evaluation of an automatic QA-system" pdf

... in too few workers and/ ortoo slow a rate of data acquisition. Therefore it is of- ten necessary to raise the reward and rely on efﬁcientautomatic validation of the data.We have looked into ... material to produce a wide selection of natural questions. Thearticles varied in topic, degree of formality and theamount of details; from ”Horror ﬁlm” and ”Christ-mas worldwide” to ”G-Man ... development of sys-tems. Automatic evaluation requires a cor-pus of questions and answers, a deﬁnition of what is a correct answer, and a way to com-pare the correct answers to automatic answersproduced...

Tài liệu Báo cáo khoa học: "Japanese Dependency Parsing Using Co-occurrence Information and a Combination of Case Elements" pdf

... VerbCandidateCandidateFigure 2: Selection of possible parses for rerankingMany methods for reranking the parsing of En-glish sentences have been proposed (Charniak and Johnson, 2005; Collins and ... contingency table of the number of correct bunsetsu (posterior context model × ourmodel) and sentence accuracies before and after rerank-ing, for the entire set of test data as well as for only those ... elements of a verb, and information about co-occurrence re-lations between a verb and its case ele-ment. This information can be collectedfrom the results of automatic dependencyparsing of large-scale...

Báo cáo khoa học: A simple in vivo assay for measuring the efﬁciency of gene length-dependent processes in yeast mRNA biogenesis doc

... This work was supported by the Ministry of Education and Science of Spain (grant BMC2003-07072-C03-01 to SC and fellowships to MM-H and to MV), and by the Andalusian Government (CVI271).References1 ... the draft; we also thankS. Buratowski, T. Kokubo, A. Ponticelli, J. Svejstrup,F. Winston and R. Young for strains and plasmids, and Antonio Garcı´a-Susperregui for strains construc-tion. This ... interactions of GCN5 with the elon-gator [53], the sensitivity of several SAGA mutants to mycophenolic acid [54] and the genetic interactionsbetween genes encoding SAGA subunits and elonga-tion factors...

Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx

... possibility of the inhibition of other lipid or pro-Fig. 1. IGF-1 induced activation of mTOR signaling is prevented by PI3K inhibitor wortmannin and mTOR inhibitor rapamycin. C2C12 myotubesat 4 days of ... activity of the TSC1 ⁄ TSC2complex and Rheb.Results and DiscussionIGF-1-induced activation of mTOR signaling isprevented by PI3K inhibitor wortmannin and mTOR inhibitor rapamycinIn the present ... leads to its translocation from the mem-brane to the cytosol and it is this physical separation, and not changes in GAP activity, that results in theincreased GTP-bound active form of Rheb and...

Báo cáo khoa học: Coiled–coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms pptx

... were used to dis-criminate between the different splice isoform partners,we observed homomultimerization by DMPK isoformsE and F, as well as heteromultimerization betweenisoforms E and F (Fig. ... DMPK isoforms A and B to the endoplasmic reticulum (ER) and DMPK C and D to the mitochondrial outer membrane (MOM)[5,24]. Speciﬁc elements in the coiled-coil domainexclusively affect the mitochondrial ... steptowards a better understanding of the role of thecoiled-coil segment in the differential structure–func-tion properties of the different isoforms, we performedgel ﬁltration experiments to...

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