báo cáo khoa học: " Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion" potx

... 1 of 11 (page number not for citation purposes) Journal of Nanobiotechnology Open Access Research Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied ... oral bioavailability of around 40% (Capsule). Therefore the aim of the present investigation was to assess the skin permeation mechanism and bioavailabili...

Ngày tải lên: 11/08/2014, 00:22

... dialyzed solution of AS60 (300 mL) obtained from 100 g of defatted ink powder contained 2.9 g of protein, 0.29 g of hexose, 0.25 g of uronic acid, 0.12 g of methylpentose and 5400 units of tyrosinase ... properties of the squid tyrosinase Effects of pH and temperature on stability and acti- vity. As ST94 and ST94t showed the identical results on pH- and temperatur...

Ngày tải lên: 17/03/2014, 10:20

... the structures of PSs from E. coli and M. tuberculosis. Structural analyses Analysis of the sites of substrate binding from NMR data, and structural comparison of the E. coli, M. tuberculosis and A. ... 164° and )169° in the A-chain and B- chain of nPS, respectively. The v 1 torsion angle for Asp35 changes from ) 75.20° to )171.65° and )89.25° in the A-chain and...

Ngày tải lên: 16/02/2014, 09:20

... dorsal surface and into the gut of the amphibian [1–4]. A number of different types of bioactive peptides have been identified from the glandular skin secretions of Australian anurans of the Litoria ... antibiotic peptide in the secretion of the skin glands of L. citropa [9]. It is one of the most potent membrane-active antibiotic peptides isolated from amphibians an...

Ngày tải lên: 17/03/2014, 09:20

... state. The actual and detailed mechanism of GC activation by ANP, namely the signal transduction mechanism, must await determination of NPRA’s GCD structure and ultimately the structure of full-length ... allows determination of the native structures in the absence of crystal contacts and in solution conditions closer to those of the native environment. The three-dimensi...

Ngày tải lên: 28/03/2014, 23:20

... diagnosis of breast cancer and more use of ster- eotactic technique in diagnosis of breast carcinoma. All the margins of mastectomy were negative and the rate of malignant involvement of nipple-areole ... died because of cardiac events. Discussion Rising popularity of skin sparing mastectomy is due to better understanding of tumor biology and pattern of recurrence....

Ngày tải lên: 09/08/2014, 07:21

... 7.0 and 4 °C for 6 h, followed by SDS ⁄ PAGE. The rate of ligation was estimated from percentage intensity of the band of the 57-kDa protein in a total of intensities of the 57-kDa, 38-kDa and ... surrogate of the c-carboxy group of Glu78 of the wild-type enzyme. Moreover, a comparison of log k cat vs. pH profiles of the E78H and E78H ⁄ D164N mutants provides clues...

Ngày tải lên: 19/02/2014, 07:20

... splicing. A variety of tools are available to us for this purpose and further investigation of these sequence variants will not only further our understanding of the splicing mechanism and improve clinical ... (mouse–rat and human–dog) [10]. This analysis showed a strong puri- fying selection at silent sites in a critical region of this gene [10], spanning the 3¢ end of exon...

Ngày tải lên: 06/03/2014, 09:22

... BC, DE and FG loops Y/A/S/D library in all the CDR loops [ref 38] Y/S library in all the CDRs of heavy chain and CDR3 of light chain [ref 39] 10 FN3 Randomization in CDR loops of heavy and light ... VEGF were selected from a restricted library constructed from only Tyr, Ser, Asp, and Ala, and X-ray structural analysis demonstrated the importance of Tyr residues [38]. The...

Ngày tải lên: 06/03/2014, 11:20

... analysis of the total cross section of mat foundation (b) Stress dispersion of the total cross section of mat foundation during and after curing (c) TCI of the total cross section of mat ... According to the table applied curing method can prevent from harmful cracks, recording TCI of 1.03 to 1.19. Table 3. The results of thermal stress by temperature of concr...

Ngày tải lên: 07/03/2014, 03:20