... mutation thatintroduces an extra four amino acids [45], a single amino aciddeletion [20], and an inframe interstitial deletion of nine aminoacids, all in the extracellular domain [16]. Remarkably, ... E, Gadina M, Karenko L, Petters-son T, et al.: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of domi-nantly inherited autoinflammatory syndromes. ... migrating radial rash on the limbs, and extreme abdominal and muscle pain, butsymptoms can also include conjunctivitis, headaches, chestpain, myalgia, arthralgia, and less commonly arthritis andother...