báo cáo khoa học: "Targeted therapy in lymphoma" docx

... proteins involved in the regulation of cell growth [15]. The proteasome activates nuclear factor-B (NF-B) signaling by degrading IB kinase (eg, the NF- B inhibitory protein), resulting in the ... reported in 65% of patients [35]. Combination therapy with bortezomib is being evalu- ated further in an ongoing open-label, international phase III study. In this study, standard R-C...

Ngày tải lên: 10/08/2014, 22:21

... reported in any patient. Keratitis occurred in 5 patients (10.6%), xerophthalmia in 9 (19.1%), cataract in 12 (25.5%), cor- neal ulceration occurred in one patient (2.1%), and minor retinopathy in ... to obtain local con- trol in the range of 89-100% using radiotherapy in low or moderate doses as 25-36 Gy. A summary of findings of some of published major studies on the issue i...

Ngày tải lên: 09/08/2014, 10:20

... 2) continuing only the third-genera- tion non-platinum compound used in the induction regimen; 3) switching to a different agent after induction therapy. Continuing first-line induction therapy The ... reported in the ASCO guideline update in 2009 [17,18]. Continuing the same non-platinum compound used in the induction regimen In patients responding or stable after the induction...

Ngày tải lên: 10/08/2014, 10:21

... polarity for textual infer- ence. In Proceedings of ICoS-5. Olivia Sanchez-Graillet and Massimo Poesio. 2007. Dis- covering contradiction protein-protein interactions in text. In Proceedings of BioNLP ... applied to intelligence reports, demonstrating which infor- mation may need further verification. In bioinfor- matics where protein-protein interaction is widely studied, automaticall...

Ngày tải lên: 17/03/2014, 02:20

... specific sequences that are involved in dimerization, while the intracellular domain is a catalytic site that has tyrosine kinase activity. EGFR binds soluble ligands, including epidermal growth factors (EGFs) ... a for- ward-thinking design when it was conceived, because the EPIC study showed activity of cetuximab in second line therapy for irinotecan-naïve patients. With more convinc-...

Ngày tải lên: 10/08/2014, 22:20

... the importin a3 subfamily includes importin a3 (karyoph- erin a4, Qip1) and importin a4 (karyopherin a3, Qip2); and the importin a5 subfamily includes impor- tin a5 (karyopherin a1, NPI-1) and importin ... [4]. These importin a isoforms have distinct binding characteristics for various NLS-containing proteins in vitro [5–7]. Furthermore, previous studies indicated that the importin a isofor...

Ngày tải lên: 28/03/2014, 23:20

Ngày tải lên: 07/08/2014, 20:23

... treatment regimens have been reported, including 5-fluorouracil, doxorubicin, and mitomycin (FAM) [4], epirubicin and cisplatin (CDDP) in combination with continuous infusion of 5-fluorouracil (ECF) ... trans- ferase was increased when docetaxel was administered in combination with S-1. In addition, in recent retrospective and phase I/II study [13,14,24], the combination therapy dem...

Ngày tải lên: 09/08/2014, 03:21

... premenopousal in no-RT group. Interestingly any patient with LRR had no extra- nodal extension in our series. As for DM, lymphatic inva- sion had an impact on LRRs existing in 5 out of 6 (83%). All LRRs in ... above the seventh rib. Any relapse involving the axillary lymph nodes, and/or other nodes in the infra or supraclavicular fossa or in the internal mammary chain was consider...

Ngày tải lên: 09/08/2014, 09:20

... median VolTotGy in Controls was 2.3 times above VolTotGy in Cases (r = 0.003), with large inter-individual variations in both groups. The volume of the thyroid gland receiving < 30 Gy in Controls ... This resulted in significantly smaller absolute thyroid sub-volumes receiving ≥ 30 Gy in Cases than in Controls. The median of the individual mean thyroid dose was 31 Gy [22Gy-42...

Ngày tải lên: 09/08/2014, 09:20